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    Orc2 origin recognition complex, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 18393, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Orc2provided by MGI
    Official Full Name
    origin recognition complex, subunit 2provided by MGI
    Primary source
    MGI:MGI:1328306
    See related
    Ensembl:ENSMUSG00000026037 AllianceGenome:MGI:1328306
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Orc2l
    Summary
    Enables DNA replication origin binding activity. Predicted to be involved in DNA replication. Located in heterochromatin. Part of inner kinetochore and nuclear origin of replication recognition complex. Is expressed in several structures, including 1st branchial arch maxillary component; genitourinary system; liver; sensory organ; and spleen. Orthologous to human ORC2 (origin recognition complex subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 14.2), liver E14.5 (RPKM 11.5) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1 C1.3; 1 29.1 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (58501933..58544114, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (58462771..58505113, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_01013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58480276-58480459 Neighboring gene STARR-positive B cell enhancer ABC_E5756 Neighboring gene CDC-like kinase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58501960-58502147 Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:58502340-58502523 Neighboring gene peptidylprolyl isomerase (cyclophilin)-like 3 Neighboring gene Ngg1 interacting factor 3-like 1 (S. pombe) Neighboring gene predicted gene, 23966 Neighboring gene STARR-seq mESC enhancer starr_01014 Neighboring gene STARR-positive B cell enhancer ABC_E3277 Neighboring gene predicted gene 15834 Neighboring gene STARR-seq mESC enhancer starr_01015 Neighboring gene hyccin PI4KA lipid kinase complex subunit 2 Neighboring gene STARR-positive B cell enhancer ABC_E10012 Neighboring gene NADH:ubiquinone oxidoreductase subunit B3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Ortega MA, et al. Biol Reprod, 2012 Sep. PMID 22674395, Free PMC Article
    2. Diverse factors are involved in maintaining X chromosome inactivation. Chan KM, et al. Proc Natl Acad Sci U S A, 2011 Oct 4. PMID 21940502, Free PMC Article
    3. Mouse pre-replicative complex proteins colocalise and interact with the centrosome. Stuermer A, et al. Eur J Cell Biol, 2007 Jan. PMID 17157410
    4. Mouse and human homologues of the yeast origin of replication recognition complex subunit ORC2 and chromosomal localization of the cognate human gene ORC2L. Takahara K, et al. Genomics, 1996 Jan 1. PMID 8808289
    5. Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation. Miyake Y, et al. J Biol Chem, 2005 Apr 1. PMID 15634681

    See all (38) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
      Title: Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote.
    2. Depletion of Orc2 and Mcm3 by siRNA leads to an inhibition of cell proliferation, an altered cell cycle distribution as well as to multinucleated cells with insufficiently organised microtubules.
      Title: Mouse pre-replicative complex proteins colocalise and interact with the centrosome.
    3. mouse Orc1, Orc2, and Orc3 each exist in two alternative-splicing variants and naturally occurring Orc1B lacks a functional domain that is essential for nuclear translocation and proteasome-dependent degradation
      Title: Novel splicing variant of mouse Orc1 is deficient in nuclear translocation and resistant for proteasome-mediated degradation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA replication origin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA replication origin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA replication initiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with chromosome, telomeric region ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of heterochromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of heterochromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of inner kinetochore IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear origin of replication recognition complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of nuclear origin of replication recognition complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear origin of replication recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of nuclear origin of replication recognition complex NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of origin recognition complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    origin recognition complex subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025378.3 → NP_001020549.1  origin recognition complex subunit 2 isoform B

      See identical proteins and their annotated locations for NP_001020549.1

      Status: VALIDATED

      Source sequence(s)
      AC118698
      Consensus CDS
      CCDS14974.1
      UniProtKB/TrEMBL
      Q59IX1
      Related
      ENSMUSP00000109964.2, ENSMUST00000114325.8
      Conserved Domains (1) summary
      pfam04084
      Location:208 → 513
      ORC2; Origin recognition complex subunit 2

    2. NM_001271526.2 → NP_001258455.1  origin recognition complex subunit 2 isoform A

      See identical proteins and their annotated locations for NP_001258455.1

      Status: VALIDATED

      Source sequence(s)
      AC118698
      Consensus CDS
      CCDS14975.1
      UniProtKB/Swiss-Prot
      Q60862
      UniProtKB/TrEMBL
      Q543F8
      Conserved Domains (1) summary
      pfam04084
      Location:255 → 561
      ORC2; Origin recognition complex subunit 2

    3. NM_001420407.1 → NP_001407336.1  origin recognition complex subunit 2 isoform A

      Status: VALIDATED

      Source sequence(s)
      AC118698
      UniProtKB/Swiss-Prot
      Q60862
      UniProtKB/TrEMBL
      Q543F8

    4. NM_001420408.1 → NP_001407337.1  origin recognition complex subunit 2 isoform C

      Status: VALIDATED

      Source sequence(s)
      AC118698

    5. NM_001420409.1 → NP_001407338.1  origin recognition complex subunit 2 isoform D

      Status: VALIDATED

      Source sequence(s)
      AC118698

    6. NM_001420410.1 → NP_001407339.1  origin recognition complex subunit 2 isoform B

      Status: VALIDATED

      Source sequence(s)
      AC118698
      UniProtKB/TrEMBL
      Q59IX1

    7. NM_001420411.1 → NP_001407340.1  origin recognition complex subunit 2 isoform E

      Status: VALIDATED

      Source sequence(s)
      AC118698

    8. NM_008765.4 → NP_032791.1  origin recognition complex subunit 2 isoform A

      See identical proteins and their annotated locations for NP_032791.1

      Status: VALIDATED

      Source sequence(s)
      AC118698
      Consensus CDS
      CCDS14975.1
      UniProtKB/Swiss-Prot
      Q60862
      UniProtKB/TrEMBL
      Q543F8
      Related
      ENSMUSP00000027198.6, ENSMUST00000027198.12
      Conserved Domains (1) summary
      pfam04084
      Location:255 → 561
      ORC2; Origin recognition complex subunit 2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      58501933..58544114 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q60862.1 GenPept UniProtKB/Swiss-Prot:Q60862

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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