Tcf4 transcription factor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tcf4provided by MGI
Official Full Name: transcription factor 4provided by MGI
Primary source: MGI:MGI:98506
See related: Ensembl:ENSMUSG00000053477 AllianceGenome:MGI:98506
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ME2; TFE; E2-2; E2.2; ITF2; SEF2; ITF-2; SEF-2; Tcf-4; ASP-I2; ITF-2b; SEF2-1; MITF-2A; MITF-2B; bHLHb19; 5730422P05Rik
Summary: Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; E-box binding activity; and TFIIB-class transcription factor binding activity. Involved in positive regulation of neuron differentiation; positive regulation of transcription by RNA polymerase II; and protein-DNA complex assembly. Acts upstream of or within several processes, including negative regulation of angiogenesis; negative regulation of macromolecule metabolic process; and regulation of vascular endothelial growth factor signaling pathway. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study Pitt-Hopkins syndrome and schizophrenia. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Note: Tcf4 (GeneID: 21413) and Tcf7l2 (GeneID: 21416) loci share the Tcf4 symbol/alias in common. Tcf4 is a widely used alternative name for T-cell-specific transcription factor 4 (Tcf7l2) conflicting with the official symbol for transcription factor 4 (Tcf4). [26 Jun 2008]
Expression: Broad expression in limb E14.5 (RPKM 8.1), frontal lobe adult (RPKM 8.1) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 18 E2; 18 43.23 cM

Exon count:: 28

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	18	NC_000084.7 (69476500..69821038)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	18	NC_000084.6 (69343429..69687967)

Chromosome 18 - NC_000084.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.
Title: Psychiatric risk gene Transcription Factor 4 (TCF4) regulates the density and connectivity of distinct inhibitory interneuron subtypes.
Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
Title: Rescue of behavioral and electrophysiological phenotypes in a Pitt-Hopkins syndrome mouse model by genetic restoration of Tcf4 expression.
Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
Title: Adult neural stem cells have latent inflammatory potential that is kept suppressed by Tcf4 to facilitate adult neurogenesis.
TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
Title: TCF4 and HuR mediated-METTL14 suppresses dissemination of colorectal cancer via N6-methyladenosine-dependent silencing of ARRDC4.
MicroRNA190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4.
Title: MicroRNA‑190b expression predicts a good prognosis and attenuates the malignant progression of pancreatic cancer by targeting MEF2C and TCF4.
Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression.
Title: Disordered breathing in a Pitt-Hopkins syndrome model involves Phox2b-expressing parafacial neurons and aberrant Nav1.8 expression.
Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.
Title: Isoform-Specific Reduction of the Basic Helix-Loop-Helix Transcription Factor TCF4 Levels in Huntington's Disease.
Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration.
Title: Transcription Factor 4 Safeguards Hippocampal Dentate Gyrus Development by Regulating Neural Progenitor Migration.
Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development.
Title: Survival control of oligodendrocyte progenitor cells requires the transcription factor 4 during olfactory bulb development.
Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice.
Title: Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice.

Submit: New GeneRIF Correction See all GeneRIFs (64)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (5) 1 citation
Endonuclease-mediated (7) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

UniSTS:237838 (e-PCR)
- UniSTS:237838

RH125520 (e-PCR)
- UniSTS:162337

mHAa57c10.seq (e-PCR)
- UniSTS:125988

D18Mit33 (e-PCR), detects polymorphism
- UniSTS:116806

Tcf4 (e-PCR), detects polymorphism
- UniSTS:507273

Tcf4 (e-PCR), detects polymorphism
- UniSTS:548020

BE197901 (e-PCR)
- UniSTS:209396

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IMP Inferred from Mutant Phenotype more info	PubMed
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IDA Inferred from Direct Assay more info	PubMed
enables E-box binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables TFIIB-class transcription factor binding	IDA Inferred from Direct Assay more info	PubMed
enables bHLH transcription factor binding	ISO Inferred from Sequence Orthology more info
enables beta-catenin binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info
enables protein heterodimerization activity	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific double-stranded DNA binding	ISO Inferred from Sequence Orthology more info
enables transcription corepressor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within endothelial cell activation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of angiogenesis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of gene expression	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info
acts_upstream_of_or_within nervous system development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of neuron differentiation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in protein-DNA complex assembly	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of vascular endothelial growth factor signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
part_of beta-catenin-TCF complex	ISO Inferred from Sequence Orthology more info
part_of beta-catenin-TCF7L2 complex	ISO Inferred from Sequence Orthology more info
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of transcription regulator complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: transcription factor 4

Names: MITF-2; SL3-3 enhancer factor 2; Transcription factor 4 (Immunoglobulin transcription factor 2) (ITF-2) (MITF-2) (SL3-3 enhancer factor 2) (SEF-2) (Class A helix-loop-helix transcription factor ME2); class A helix-loop-helix transcription factor ME2; immunoglobulin transcription factor-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001083967.1 → NP_001077436.1 transcription factor 4 isoform b

See identical proteins and their annotated locations for NP_001077436.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1, resulting in a shorter protein (isoform b).

Source sequence(s)

AK039181, AK047926, AK081012, BC043050, BY770794, CB247941

Consensus CDS

CCDS50315.1

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000110633.2, ENSMUST00000114982.8

Conserved Domains (1) summary

cd18945
Location:557 → 641

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_001361126.1 → NP_001348055.1 transcription factor 4 isoform b

Status: VALIDATED

Source sequence(s)

AC109258, AC157576, AC163095, AC169193

Consensus CDS

CCDS50315.1

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000144512.2, ENSMUST00000202116.4

Conserved Domains (1) summary

cd18945
Location:557 → 641

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_001361127.1 → NP_001348056.1 transcription factor 4 isoform a

Status: VALIDATED

Source sequence(s)

AC109258, AC157576, AC163095, AC169193

Consensus CDS

CCDS29329.1

UniProtKB/Swiss-Prot

Q60721, Q60722, Q62211, Q64072, Q80UE8

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000077577.7, ENSMUST00000078486.13

Conserved Domains (1) summary

cd18945
Location:561 → 645

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_001361128.1 → NP_001348057.1 transcription factor 4 isoform c

Status: VALIDATED

Source sequence(s)

AC109258, AC157576, AC163095, AC169193

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_001361129.1 → NP_001348058.1 transcription factor 4 isoform c

Status: VALIDATED

Source sequence(s)

AC109258, AC157576, AC163095, AC169193

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
NM_013685.2 → NP_038713.1 transcription factor 4 isoform a

See identical proteins and their annotated locations for NP_038713.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and it encodes the longer protein (isoform a).

Source sequence(s)

AK039181, AK047926, AK051958, BC043050, CB247941, U16322

Consensus CDS

CCDS29329.1

UniProtKB/Swiss-Prot

Q60721, Q60722, Q62211, Q64072, Q80UE8

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000110636.4, ENSMUST00000114985.10

Conserved Domains (1) summary

cd18945
Location:561 → 645

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000084.7 Reference GRCm39 C57BL/6J

Range

69476500..69821038

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017317857.2 → XP_017173346.1 transcription factor 4 isoform X5

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:557 → 641

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250374.1 → XP_030106234.1 transcription factor 4 isoform X3

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317854.2 → XP_017173343.1 transcription factor 4 isoform X2

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250376.1 → XP_030106236.1 transcription factor 4 isoform X6

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:556 → 640

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250375.1 → XP_030106235.1 transcription factor 4 isoform X4

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:559 → 643

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250384.1 → XP_030106244.1 transcription factor 4 isoform X15

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:453 → 537

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525753.4 → XP_006525816.1 transcription factor 4 isoform X9

UniProtKB/TrEMBL

A0A0J9YUK1, A0A0J9YUZ0

Related

ENSMUSP00000144209.2, ENSMUST00000201781.4

Conserved Domains (1) summary

cd18945
Location:537 → 621

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250382.1 → XP_030106242.1 transcription factor 4 isoform X12

UniProtKB/TrEMBL

A0A0J9YUK1, A0A0J9YUP9

Related

ENSMUSP00000144285.2, ENSMUST00000201631.4

Conserved Domains (1) summary

cd18945
Location:533 → 617

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250381.1 → XP_030106241.1 transcription factor 4 isoform X11

UniProtKB/TrEMBL

A0A0J9YUK1

Conserved Domains (1) summary

cd18945
Location:536 → 620

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161052.1 → XP_036016945.1 transcription factor 4 isoform X13

UniProtKB/TrEMBL

A0A0J9YUK1, A0A0J9YVG2

Related

ENSMUSP00000144646.2, ENSMUST00000202354.4

Conserved Domains (1) summary

cd18945
Location:532 → 616

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317859.2 → XP_017173348.1 transcription factor 4 isoform X10

UniProtKB/TrEMBL

A0A0J9YUK1

Conserved Domains (1) summary

cd18945
Location:536 → 620

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250386.1 → XP_030106246.1 transcription factor 4 isoform X15

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:453 → 537

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161051.1 → XP_036016944.1 transcription factor 4 isoform X7

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:556 → 640

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250377.2 → XP_030106237.1 transcription factor 4 isoform X6

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000143987.2, ENSMUST00000202772.4

Conserved Domains (1) summary

cd18945
Location:556 → 640

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250373.2 → XP_030106233.1 transcription factor 4 isoform X2

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161049.1 → XP_036016942.1 transcription factor 4 isoform X1

UniProtKB/Swiss-Prot

Q60721, Q60722, Q62211, Q64072, Q80UE8

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000144670.2, ENSMUST00000202610.4

Conserved Domains (1) summary

cd18945
Location:561 → 645

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525746.5 → XP_006525809.1 transcription factor 4 isoform X1

See identical proteins and their annotated locations for XP_006525809.1

UniProtKB/Swiss-Prot

Q60721, Q60722, Q62211, Q64072, Q80UE8

UniProtKB/TrEMBL

Q8CE98

Related

ENSMUSP00000110631.3, ENSMUST00000114980.8

Conserved Domains (1) summary

cd18945
Location:561 → 645

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525752.4 → XP_006525815.1 transcription factor 4 isoform X7

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:556 → 640

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525748.4 → XP_006525811.1 transcription factor 4 isoform X2

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:560 → 644

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525751.5 → XP_006525814.1 transcription factor 4 isoform X6

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:556 → 640

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317856.3 → XP_017173345.1 transcription factor 4 isoform X4

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:559 → 643

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317858.2 → XP_017173347.1 transcription factor 4 isoform X8

UniProtKB/TrEMBL

Q8CE98

Conserved Domains (1) summary

cd18945
Location:555 → 639

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161055.1 → XP_036016948.1 transcription factor 4 isoform X16

UniProtKB/TrEMBL

A0A0J9YTW1

Related

ENSMUSP00000143875.2, ENSMUST00000202458.4

Conserved Domains (1) summary

cd18945
Location:449 → 533

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250379.1 → XP_030106239.1 transcription factor 4 isoform X9

UniProtKB/TrEMBL

A0A0J9YUK1, A0A0J9YUZ0

Conserved Domains (1) summary

cd18945
Location:537 → 621

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250378.2 → XP_030106238.1 transcription factor 4 isoform X9

UniProtKB/TrEMBL

A0A0J9YUK1, A0A0J9YUZ0

Related

ENSMUSP00000144407.2, ENSMUST00000202435.4

Conserved Domains (1) summary

cd18945
Location:537 → 621

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250380.2 → XP_030106240.1 transcription factor 4 isoform X10

UniProtKB/TrEMBL

A0A0J9YUK1

Conserved Domains (1) summary

cd18945
Location:536 → 620

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250387.1 → XP_030106247.1 transcription factor 4 isoform X15

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:453 → 537

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161056.1 → XP_036016949.1 transcription factor 4 isoform X16

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:449 → 533

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161053.1 → XP_036016946.1 transcription factor 4 isoform X14

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:485 → 569

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317863.3 → XP_017173352.1 transcription factor 4 isoform X17

UniProtKB/TrEMBL

A0A0J9YTU7, A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:432 → 516

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317861.3 → XP_017173350.1 transcription factor 4 isoform X19

UniProtKB/TrEMBL

A0A0J9YTW1, A0A0J9YUG4

Related

ENSMUSP00000144169.2, ENSMUST00000201094.4

Conserved Domains (1) summary

cd18945
Location:428 → 512

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250390.2 → XP_030106250.1 transcription factor 4 isoform X17

UniProtKB/TrEMBL

A0A0J9YTU7, A0A0J9YTW1

Related

ENSMUSP00000144273.2, ENSMUST00000201205.4

Conserved Domains (1) summary

cd18945
Location:432 → 516

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250392.2 → XP_030106252.1 transcription factor 4 isoform X19

UniProtKB/TrEMBL

A0A0J9YTW1, A0A0J9YUG4

Related

ENSMUSP00000143950.2, ENSMUST00000201410.4

Conserved Domains (1) summary

cd18945
Location:428 → 512

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_017317860.2 → XP_017173349.1 transcription factor 4 isoform X17

UniProtKB/TrEMBL

A0A0J9YTU7, A0A0J9YTW1

Related

ENSMUSP00000143857.2, ENSMUST00000202937.4

Conserved Domains (1) summary

cd18945
Location:432 → 516

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250393.2 → XP_030106253.1 transcription factor 4 isoform X19

UniProtKB/TrEMBL

A0A0J9YTW1, A0A0J9YUG4

Related

ENSMUSP00000144219.2, ENSMUST00000202477.4

Conserved Domains (1) summary

cd18945
Location:428 → 512

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525759.4 → XP_006525822.1 transcription factor 4 isoform X17

See identical proteins and their annotated locations for XP_006525822.1

UniProtKB/TrEMBL

A0A0J9YTU7, A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:432 → 516

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250394.2 → XP_030106254.1 transcription factor 4 isoform X19

UniProtKB/TrEMBL

A0A0J9YTW1, A0A0J9YUG4

Related

ENSMUSP00000144647.2, ENSMUST00000202057.4

Conserved Domains (1) summary

cd18945
Location:428 → 512

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_036161057.1 → XP_036016950.1 transcription factor 4 isoform X18

UniProtKB/TrEMBL

A0A0J9YTW1

Conserved Domains (1) summary

cd18945
Location:431 → 515

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525760.4 → XP_006525823.1 transcription factor 4 isoform X20

See identical proteins and their annotated locations for XP_006525823.1

UniProtKB/TrEMBL

A0A0J9YTR9, Q91XK1

Related

ENSMUSP00000110629.3, ENSMUST00000114978.9

Conserved Domains (1) summary

cd18945
Location:402 → 486

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525762.4 → XP_006525825.1 transcription factor 4 isoform X22

See identical proteins and their annotated locations for XP_006525825.1

UniProtKB/TrEMBL

A0A0J9YTR9, Q91YV0

Related

ENSMUSP00000110628.2, ENSMUST00000114977.5

Conserved Domains (1) summary

cd18945
Location:398 → 482

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_006525766.4 → XP_006525829.1 transcription factor 4 isoform X21

UniProtKB/TrEMBL

A0A0J9YTR9

Conserved Domains (1) summary

cd18945
Location:401 → 485

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins
XM_030250397.1 → XP_030106257.1 transcription factor 4 isoform X23

UniProtKB/TrEMBL

A0A0J9YTR9

Conserved Domains (1) summary

cd18945
Location:397 → 481

bHLH_E-protein_TCF4_E2-2; basic helix-loop-helix (bHLH) domain found in transcription factor 4 (TCF-4) and similar proteins