U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Hsd17b14 hydroxysteroid (17-beta) dehydrogenase 14 [ Mus musculus (house mouse) ]

    Gene ID: 66065, updated on 14-May-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Hsd17b14provided by MGI
    Official Full Name
    hydroxysteroid (17-beta) dehydrogenase 14provided by MGI
    Primary source
    MGI:MGI:1913315
    See related
    Ensembl:ENSMUSG00000030825 AllianceGenome:MGI:1913315
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dhrs10; retSDR3; 0610039E24Rik
    Summary
    Predicted to enable estradiol 17-beta-dehydrogenase activity; identical protein binding activity; and testosterone 17-beta-dehydrogenase (NADP+) activity. Predicted to be involved in steroid catabolic process. Predicted to be active in cytosol. Orthologous to human HSD17B14 (hydroxysteroid 17-beta dehydrogenase 14). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in kidney adult (RPKM 10.3), bladder adult (RPKM 5.5) and 6 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See Hsd17b14 in Genome Data Viewer
    Location:
    7 B3; 7 29.35 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (45204345..45216745)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (45554920..45567321)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene TUB like protein 2 Neighboring gene CapStarr-seq enhancer MGSCv37_chr7:52781513-52781717 Neighboring gene protein phosphatase 1, regulatory subunit 15A Neighboring gene pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 4 Neighboring gene predicted gene, 53387 Neighboring gene STARR-seq mESC enhancer starr_18846 Neighboring gene RIKEN cDNA 0610005C13 gene Neighboring gene STARR-positive B cell enhancer ABC_E3717 Neighboring gene branched chain aminotransferase 2, mitochondrial Neighboring gene STARR-positive B cell enhancer ABC_E1340 Neighboring gene STARR-positive B cell enhancer ABC_E4926 Neighboring gene predicted gene, 31479

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables estradiol 17-beta-dehydrogenase [NAD(P)] activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables testosterone 17-beta-dehydrogenase (NADP+) activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in steroid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in steroid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    17-beta-hydroxysteroid dehydrogenase 14
    Names
    dehydrogenase/reductase (SDR family) member 10
    NP_079606.3
    XP_006541132.2
    XP_006541133.1
    XP_011249191.1

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_025330.3 → NP_079606.3  17-beta-hydroxysteroid dehydrogenase 14

      Status: VALIDATED

      Source sequence(s)
      AC151602
      Consensus CDS
      CCDS21251.2
      UniProtKB/TrEMBL
      E9Q3D4
      Related
      ENSMUSP00000103381.4, ENSMUST00000107752.12
      Conserved Domains (2) summary
      PRK05653
      Location:8 → 251
      fabG; 3-ketoacyl-(acyl-carrier-protein) reductase; Validated
      cl21454
      Location:1 → 256
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      45204345..45216745
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006541070.5 → XP_006541133.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X2

      UniProtKB/TrEMBL
      A0A1B0GRY4
      Related
      ENSMUSP00000147715.2, ENSMUST00000210300.2
      Conserved Domains (1) summary
      cl21454
      Location:1 → 158
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    2. XM_011250889.3 → XP_011249191.1  17-beta-hydroxysteroid dehydrogenase 14 isoform X3

      UniProtKB/TrEMBL
      Q4FZG0
      Conserved Domains (1) summary
      cl21454
      Location:21 → 154
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006541069.2 → XP_006541132.2  17-beta-hydroxysteroid dehydrogenase 14 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:46 → 179
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous