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    Sf3b2 splicing factor 3b, subunit 2 [ Mus musculus (house mouse) ]

    Gene ID: 319322, updated on 9-May-2024

    Summary

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    Official Symbol
    Sf3b2provided by MGI
    Official Full Name
    splicing factor 3b, subunit 2provided by MGI
    Primary source
    MGI:MGI:2441856
    See related
    Ensembl:ENSMUSG00000024853 AllianceGenome:MGI:2441856
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SF3b1; 145kDa; SAP145; SF3b145; SF3b150; 2610311M13Rik; 2810441F20Rik; B230398H18Rik
    Summary
    Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in nuclear speck. Predicted to be part of U2 snRNP and spliceosomal complex. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human SF3B2 (splicing factor 3b subunit 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 77.1), CNS E14 (RPKM 51.7) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sf3b2 in Genome Data Viewer
    Location:
    19 A; 19 4.29 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (5323949..5345485, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (5273921..5295457, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein F pseudogene Neighboring gene phosphofurin acidic cluster sorting protein 1 Neighboring gene STARR-seq mESC enhancer starr_45376 Neighboring gene STARR-seq mESC enhancer starr_45378 Neighboring gene galactose-3-O-sulfotransferase 3 Neighboring gene predicted gene, 42064 Neighboring gene RNA polymerase II associated protein 2 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis. Jeong YE, et al. Ann Clin Transl Neurol, 2023 Feb. PMID 36574260, Free PMC Article
    2. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2. Murphy SA, et al. Nat Commun, 2021 Mar 12. PMID 33712605, Free PMC Article
    3. Identification of novel Smad binding proteins. Warner DR, et al. Biochem Biophys Res Commun, 2003 Dec 26. PMID 14651998
    4. Methyltransferase-like 21e inhibits 26S proteasome activity to facilitate hypertrophy of type IIb myofibers. Wang C, et al. FASEB J, 2019 Aug. PMID 31162944, Free PMC Article
    5. Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Carninci P, et al. Genome Res, 2003 Jun. PMID 12819125, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis.
      Title: Downregulation of SF3B2 protects CNS neurons in models of multiple sclerosis.
    2. PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
      Title: PGC1/PPAR drive cardiomyocyte maturation at single cell level via YAP1 and SF3B2.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of U12-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U12-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2 snRNP IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type precatalytic spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of U2-type spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of precatalytic spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    splicing factor 3B subunit 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362454.1 → NP_001349383.1  splicing factor 3B subunit 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC125059, CD776683
      Conserved Domains (3) summary
      smart00581
      Location:583 → 641
      PSP; proline-rich domain in spliceosome associated proteins
      pfam02037
      Location:24 → 57
      SAP; SAP domain
      pfam04037
      Location:453 → 578
      DUF382; Domain of unknown function (DUF382)

    2. NM_030109.2 → NP_084385.2  splicing factor 3B subunit 2 isoform 1

      See identical proteins and their annotated locations for NP_084385.2

      Status: VALIDATED

      Source sequence(s)
      AK146063, BI134679, BY785284
      Consensus CDS
      CCDS29454.1
      UniProtKB/Swiss-Prot
      A0A494B9S9, Q3UAI4, Q3UBH2, Q3UJB0, Q3UQU5, Q80W39, Q8BL33, Q9CS24
      Related
      ENSMUSP00000025774.10, ENSMUST00000025774.11
      Conserved Domains (3) summary
      smart00581
      Location:584 → 642
      PSP; proline-rich domain in spliceosome associated proteins
      pfam02037
      Location:24 → 57
      SAP; SAP domain
      pfam04037
      Location:454 → 579
      DUF382; Domain of unknown function (DUF382)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      5323949..5345485 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UJB0.1 GenPept UniProtKB/Swiss-Prot:Q3UJB0

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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