Ryr2 ryanodine receptor 2, cardiac [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ryr2provided by MGI
Official Full Name: ryanodine receptor 2, cardiacprovided by MGI
Primary source: MGI:MGI:99685
See related: Ensembl:ENSMUSG00000021313 AllianceGenome:MGI:99685
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: RYR-2; 9330127I20Rik
Summary: Enables several functions, including calmodulin binding activity; identical protein binding activity; and ryanodine-sensitive calcium-release channel activity. Involved in several processes, including cellular response to organonitrogen compound; regulation of heart contraction; and release of sequestered calcium ion into cytosol by sarcoplasmic reticulum. Acts upstream of or within several processes, including calcium ion transport; left ventricular cardiac muscle tissue morphogenesis; and response to caffeine. Located in Z disc; sarcoplasmic reticulum membrane; and smooth endoplasmic reticulum. Part of calcium channel complex. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Used to study arrhythmogenic right ventricular dysplasia 2; catecholaminergic polymorphic ventricular tachycardia 1; and heart disease. Human ortholog(s) of this gene implicated in arrhythmogenic right ventricular cardiomyopathy; arrhythmogenic right ventricular dysplasia 2; and catecholaminergic polymorphic ventricular tachycardia 1. Orthologous to human RYR2 (ryanodine receptor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in heart adult (RPKM 43.4), cortex adult (RPKM 7.6) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A1; 13 4.38 cM

Exon count:: 108

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (11567985..12121831, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (11553099..12106945, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene.
Title: Whole-exome sequencing in familial type 2 diabetes identifies an atypical missense variant in the RyR2 gene.
Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers.
Title: Phosphorylation of RyR2 simultaneously expands the dyad and rearranges the tetramers.
Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells.
Title: Foxp3-mediated blockage of ryanodine receptor 2 underlies contact-based suppression by regulatory T cells.
Heart failure-induced cognitive dysfunction is mediated by intracellular Ca[2+] leak through ryanodine receptor type 2.
Title: Heart failure-induced cognitive dysfunction is mediated by intracellular Ca(2+) leak through ryanodine receptor type 2.
Increased Ca[2+] Transient Underlies RyR2-Related Left Ventricular Noncompaction.
Title: Increased Ca(2+) Transient Underlies RyR2-Related Left Ventricular Noncompaction.
Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation.
Title: Ryanodine receptor 2 (RYR2) dysfunction activates the unfolded protein response and perturbs cardiomyocyte maturation.
A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer's Disease Mouse Models by Upregulating Neuronal Autophagy.
Title: A Gating Mutation in Ryanodine Receptor Type 2 Rescues Phenotypes of Alzheimer's Disease Mouse Models by Upregulating Neuronal Autophagy.
Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.
Title: Genetic Inhibition of Mitochondrial Permeability Transition Pore Exacerbates Ryanodine Receptor 2 Dysfunction in Arrhythmic Disease.
RyR2 Serine-2030 PKA Site Governs Ca[2+] Release Termination and Ca[2+] Alternans.
Title: RyR2 Serine-2030 PKA Site Governs Ca(2+) Release Termination and Ca(2+) Alternans.
Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.
Title: Limiting RyR2 open time prevents Alzheimer's disease-related deficits in the 3xTG-AD mouse model.

Submit: New GeneRIF Correction See all GeneRIFs (163)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (33) 1 citation
Chemically induced (ENU) (3)
Endonuclease-mediated (4) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

D13Mit134 (e-PCR), detects polymorphism
- UniSTS:116533

Ryr2 (e-PCR), detects polymorphism
- UniSTS:463223

D13Sfk11 (e-PCR), detects polymorphism
- UniSTS:141946

D13Sfk12 (e-PCR), detects polymorphism
- UniSTS:141947

PMC21940P1 (e-PCR)
- UniSTS:272079

Ryr2 (e-PCR), detects polymorphism
- UniSTS:507352

Ryr2 (e-PCR), detects polymorphism
- UniSTS:144365

24.MHAa93f12.seq (e-PCR)
- UniSTS:123629

Ryr2 (e-PCR), detects polymorphism
- UniSTS:144366

Ryr2 (e-PCR), detects polymorphism
- UniSTS:516600

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables calcium-induced calcium release activity	ISO Inferred from Sequence Orthology more info
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	ISO Inferred from Sequence Orthology more info
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables intracellularly gated calcium channel activity	IDA Inferred from Direct Assay more info	PubMed
enables intracellularly gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables monoatomic ion channel activity	IEA Inferred from Electronic Annotation more info
enables organic cyclic compound binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase A catalytic subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase A regulatory subunit binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables ryanodine-sensitive calcium-release channel activity	IDA Inferred from Direct Assay more info	PubMed
enables ryanodine-sensitive calcium-release channel activity	ISO Inferred from Sequence Orthology more info
enables scaffold protein binding	ISO Inferred from Sequence Orthology more info
enables suramin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in Purkinje myocyte to ventricular cardiac muscle cell signaling	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane import into cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within calcium ion transport	IPI Inferred from Physical Interaction more info	PubMed
involved_in calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium-mediated signaling using intracellular calcium source	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle hypertrophy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cellular response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in cellular response to epinephrine stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in detection of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in embryonic heart tube morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within establishment of localization in cell	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of protein localization to endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within left ventricular cardiac muscle tissue morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manganese ion transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in monoatomic ion transmembrane transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in monoatomic ion transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within multicellular organism development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of ATPase-coupled calcium transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of sequestering of calcium ion	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of the force of heart contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of AV node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of SA node cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of atrial cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by calcium ion signaling	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of cytosolic calcium ion concentration	ISO Inferred from Sequence Orthology more info
involved_in regulation of heart rate	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of heart rate	ISO Inferred from Sequence Orthology more info
involved_in regulation of ventricular cardiac muscle cell action potential	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol	ISO Inferred from Sequence Orthology more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in release of sequestered calcium ion into cytosol by sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to caffeine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to caffeine	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IDA Inferred from Direct Assay more info	PubMed
involved_in response to magnesium ion	ISO Inferred from Sequence Orthology more info
involved_in response to muscle activity	ISO Inferred from Sequence Orthology more info
involved_in response to muscle stretch	ISO Inferred from Sequence Orthology more info
involved_in response to redox state	ISO Inferred from Sequence Orthology more info
involved_in sarcoplasmic reticulum calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in striated muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in type B pancreatic cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle cell action potential	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in A band	ISO Inferred from Sequence Orthology more info
is_active_in Z disc	IBA Inferred from Biological aspect of Ancestor more info
located_in Z disc	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with Z disc	ISO Inferred from Sequence Orthology more info
located_in Z disc	ISO Inferred from Sequence Orthology more info
part_of calcium channel complex	IBA Inferred from Biological aspect of Ancestor more info
part_of calcium channel complex	IDA Inferred from Direct Assay more info	PubMed
part_of calcium channel complex	ISO Inferred from Sequence Orthology more info
located_in extrinsic component of cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	IC Inferred by Curator more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nuclear envelope	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info	PubMed
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	ISO Inferred from Sequence Orthology more info
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in sarcoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in smooth endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: ryanodine receptor 2

Names: calcium release channel; cardiac muscle ryanodine receptor; cardiac muscle ryanodine receptor-calcium release channel; ryanodine receptor type 2; type 2 ryanodine receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_023868.2 → NP_076357.2 ryanodine receptor 2

See identical proteins and their annotated locations for NP_076357.2

Status: VALIDATED

Source sequence(s)

AC131329, AC159208, AF295105, BB387101, BC059061, BU921357, U23755

Consensus CDS

CCDS49206.1

UniProtKB/Swiss-Prot

E9Q401, O70181, Q62174, Q62197, Q9ERN6

UniProtKB/TrEMBL

F6U7V1

Related

ENSMUSP00000021750.8, ENSMUST00000021750.15

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4717 → 4877

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4333 → 4598

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3830 → 3947

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4031 → 4086

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000079.7 Reference GRCm39 C57BL/6J

Range

11567985..12121831 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017315461.2 → XP_017170950.1 ryanodine receptor 2 isoform X17

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:642 → 793

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1074 → 1206

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1400 → 1547

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4704 → 4864

Ion_trans; Ion transport protein

pfam01365
Location:444 → 636

RYDR_ITPR; RIH domain

pfam02026
Location:2688 → 2778

RyR; RyR domain

pfam02815
Location:214 → 394

MIR; MIR domain

pfam06459
Location:4319 → 4585

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3821 → 3934

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4018 → 4073

EF-hand_7; EF-hand domain pair

cl19745
Location:13 → 204

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_006516610.2 → XP_006516673.1 ryanodine receptor 2 isoform X1

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4736 → 4896

Ion_trans; Ion transport protein

pfam01365
Location:456 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4351 → 4617

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3853 → 3966

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4050 → 4105

EF-hand_7; EF-hand domain pair

cl19745
Location:13 → 216

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157936.1 → XP_036013829.1 ryanodine receptor 2 isoform X8

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:642 → 793

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1074 → 1206

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1400 → 1547

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4724 → 4884

Ion_trans; Ion transport protein

pfam01365
Location:443 → 636

RYDR_ITPR; RIH domain

pfam02026
Location:2688 → 2778

RyR; RyR domain

pfam02815
Location:214 → 394

MIR; MIR domain

pfam06459
Location:4340 → 4605

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3837 → 3954

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4038 → 4093

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 210

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_011244296.3 → XP_011242598.1 ryanodine receptor 2 isoform X15

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:647 → 798

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1079 → 1211

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1405 → 1552

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4698 → 4858

Ion_trans; Ion transport protein

pfam01365
Location:449 → 641

RYDR_ITPR; RIH domain

pfam02026
Location:2693 → 2783

RyR; RyR domain

pfam02815
Location:219 → 399

MIR; MIR domain

pfam06459
Location:4313 → 4579

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3815 → 3928

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4012 → 4067

EF-hand_7; EF-hand domain pair

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017315455.3 → XP_017170944.1 ryanodine receptor 2 isoform X14

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:647 → 798

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1079 → 1211

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1405 → 1552

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4706 → 4866

Ion_trans; Ion transport protein

pfam01365
Location:449 → 641

RYDR_ITPR; RIH domain

pfam02026
Location:2693 → 2783

RyR; RyR domain

pfam02815
Location:219 → 399

MIR; MIR domain

pfam06459
Location:4321 → 4587

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3823 → 3936

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4020 → 4075

EF-hand_7; EF-hand domain pair

cl19745
Location:13 → 209

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157933.1 → XP_036013826.1 ryanodine receptor 2 isoform X4

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:647 → 798

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1079 → 1211

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1405 → 1552

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4729 → 4889

Ion_trans; Ion transport protein

pfam01365
Location:448 → 641

RYDR_ITPR; RIH domain

pfam02026
Location:2693 → 2783

RyR; RyR domain

pfam02815
Location:219 → 399

MIR; MIR domain

pfam06459
Location:4345 → 4610

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3842 → 3959

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4043 → 4098

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 215

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157938.1 → XP_036013831.1 ryanodine receptor 2 isoform X10

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4716 → 4876

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4332 → 4597

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3829 → 3946

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4030 → 4085

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157940.1 → XP_036013833.1 ryanodine receptor 2 isoform X12

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4713 → 4873

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4329 → 4594

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3826 → 3943

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4027 → 4082

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157935.1 → XP_036013828.1 ryanodine receptor 2 isoform X7

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4724 → 4884

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4340 → 4605

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3837 → 3954

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4038 → 4093

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157941.1 → XP_036013834.1 ryanodine receptor 2 isoform X13

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4711 → 4871

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4333 → 4592

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3830 → 3947

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4031 → 4086

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157939.1 → XP_036013832.1 ryanodine receptor 2 isoform X11

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4715 → 4875

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4333 → 4596

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3830 → 3947

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4031 → 4086

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157934.1 → XP_036013827.1 ryanodine receptor 2 isoform X5

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4728 → 4888

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4344 → 4609

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3841 → 3958

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4042 → 4097

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157937.1 → XP_036013830.1 ryanodine receptor 2 isoform X9

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4719 → 4879

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4341 → 4600

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3838 → 3955

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4039 → 4094

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_017315460.3 → XP_017170949.1 ryanodine receptor 2 isoform X6

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4725 → 4885

Ion_trans; Ion transport protein

pfam01365
Location:456 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4340 → 4606

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3842 → 3955

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4039 → 4094

EF-hand_7; EF-hand domain pair

cl19745
Location:13 → 216

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157932.1 → XP_036013825.1 ryanodine receptor 2 isoform X3

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4730 → 4890

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4352 → 4611

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3849 → 3966

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4050 → 4105

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157931.1 → XP_036013824.1 ryanodine receptor 2 isoform X2

UniProtKB/TrEMBL

F6U7V1

Conserved Domains (11) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam00520
Location:4734 → 4894

Ion_trans; Ion transport protein

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

pfam06459
Location:4352 → 4615

RR_TM4-6; Ryanodine Receptor TM 4-6

pfam08454
Location:3849 → 3966

RIH_assoc; RyR and IP3R Homology associated

pfam13499
Location:4050 → 4105

EF-hand_7; EF-hand domain pair

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor
XM_036157942.1 → XP_036013835.1 ryanodine receptor 2 isoform X16

Conserved Domains (7) summary

cd12877
Location:654 → 805

SPRY1_RyR; SPRY domain 1 (SPRY1) of ryanodine receptor (RyR)

cd12878
Location:1086 → 1218

SPRY2_RyR; SPRY domain 2 (SPRY2) of ryanodine receptor (RyR)

cd12879
Location:1412 → 1559

SPRY3_RyR; SPRY domain 3 (SPRY3) of ryanodine receptor (RyR)

pfam01365
Location:455 → 648

RYDR_ITPR; RIH domain

pfam02026
Location:2700 → 2790

RyR; RyR domain

pfam02815
Location:226 → 406

MIR; MIR domain

cl19745
Location:9 → 222

Ins145_P3_rec; Inositol 1,4,5-trisphosphate/ryanodine receptor