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    Mmp12 matrix metallopeptidase 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117033, updated on 6-May-2021

    Summary

    Official Symbol
    Mmp12provided by RGD
    Official Full Name
    matrix metallopeptidase 12provided by RGD
    Primary source
    RGD:620195
    See related
    Ensembl:ENSRNOG00000030187
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mme
    Summary
    a macrophage metalloelastase/matrix metalloproteinase; may have a role in glomerular injury in a crescentic glomerulonephritis [RGD, Feb 2006]
    Expression
    Biased expression in Thymus (RPKM 140.7), Spleen (RPKM 50.9) and 5 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Mmp12 in Genome Data Viewer
    Location:
    8q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    108 current mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4581785..4591687)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (5594717..5616494)

    Chromosome 8 - NC_051343.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 13 Neighboring gene similar to Aspartyl-tRNA synthetase (Aspartate--tRNA ligase) (AspRS) Neighboring gene matrix metallopeptidase 1b (interstitial collagenase) Neighboring gene matrix metallopeptidase 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    General gene information

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables calcium ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables collagen binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables collagen binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables core promoter sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables core promoter sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metalloendopeptidase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables zinc ion binding ISO
    Inferred from Sequence Orthology
    more info
     
    Process Evidence Code Pubs
    involved_in bronchiole development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within bronchiole development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to virus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in elastin catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in elastin catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    PubMed 
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within lung alveolus development ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of endothelial cell-matrix adhesion via fibronectin IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of endothelial cell-matrix adhesion via fibronectin ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of epithelial cell proliferation IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in positive regulation of epithelial cell proliferation involved in wound healing IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell proliferation involved in wound healing ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interferon-alpha production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interferon-alpha production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of type I interferon-mediated signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein import into nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in proteolysis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of defense response to virus by host IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of trophoblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to drug IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to hypoxia IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in response to organic cyclic compound IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in wound healing, spreading of epidermal cells IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of epidermal cells ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    macrophage metalloelastase
    Names
    MMP-12
    matrix metalloproteinase-12
    NP_446415.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_053963.2NP_446415.2  macrophage metalloelastase preproprotein

      See identical proteins and their annotated locations for NP_446415.2

      Status: VALIDATED

      Source sequence(s)
      BC088120, CB791502
      UniProtKB/Swiss-Prot
      Q63341
      UniProtKB/TrEMBL
      R9PXT7
      Related
      ENSRNOP00000011727.6, ENSRNOT00000011727.6
      Conserved Domains (4) summary
      cd00094
      Location:293477
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      cd04278
      Location:116271
      ZnMc_MMP; Zinc-dependent metalloprotease, matrix metalloproteinase (MMP) sub-family. MMPs are responsible for a great deal of pericellular proteolysis of extracellular matrix and cell surface molecules, playing crucial roles in morphogenesis, cell fate ...
      pfam00413
      Location:116271
      Peptidase_M10; Matrixin
      pfam01471
      Location:4195
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: Rattus norvegicus Annotation Release 108 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference mRatBN7.2 Primary Assembly

    Genomic

    1. NC_051343.1 Reference mRatBN7.2 Primary Assembly

      Range
      4581785..4591687
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
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