Ccn5 cellular communication network factor 5 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ccn5provided by RGD
Official Full Name: cellular communication network factor 5provided by RGD
Primary source: RGD:621867
See related: Ensembl:ENSRNOG00000010666 AllianceGenome:RGD:621867
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Wisp2
Summary: Enables integrin binding activity. Involved in negative regulation of cell population proliferation. Located in several cellular components, including cell surface; nucleus; and podosome. Orthologous to human CCN5 (cellular communication network factor 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 121.7), Heart (RPKM 61.9) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q42

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (172910670..172922064)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (152491247..152502639)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (160207969..160219316)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARgamma in vitro.
Title: WISP-2, an upregulated gene in hip cartilage from the DDH model rats, induces chondrocyte apoptosis through PPARγ in vitro.
miR-450a-5p promoted adipogenesis through repressing expression of WISP2 by targeting its 3' untranslated region.
Title: miR-450a-5p within rat adipose tissue exosome-like vesicles promotes adipogenic differentiation by targeting WISP2.
COP-1 immunization might increase NT-3 expression by some unknown mechanism in high IOP rats and the change may be related to COP-1 therapeutic intervention.
Title: Copolymer-1 immunization reduces damage in retinal ganglion cells under high intraocular pressure through altering the expression of retinal neurotrophins.
data indicate that CCN5 protein is positively regulated by estrogen in the rat uterus and suggests that this gene may play an important role in maintaining normal uterine physiology
Title: Estrogen induces CCN5 expression in the rat uterus in vivo.

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General gene information

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Markers

Wisp2 (e-PCR), detects polymorphism
- UniSTS:527128

PMC293470P1 (e-PCR)
- UniSTS:272450

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables heparin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IBA Inferred from Biological aspect of Ancestor more info
enables integrin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cell growth	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in podosome	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: CCN family member 5

Names: CCN family protein COP-1; CTGF-L; WISP-2; WNT1 inducible signaling pathway protein 2; connective tissue growth factor-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031590.2 → NP_113778.2 CCN family member 5 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000003

UniProtKB/Swiss-Prot

Q9JHC6

UniProtKB/TrEMBL

A6JX49, G3V7F3

Related

ENSRNOP00000014346.4, ENSRNOT00000014346.7

Conserved Domains (3) summary

cl17735
Location:100 → 159

VWC; von Willebrand factor type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:194 → 237

TSP1_CCN; CCN3 Nov like TSP1 domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

172910670..172922064

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039104504.1 → XP_038960432.1 CCN family member 5 isoform X1

UniProtKB/Swiss-Prot

Q9JHC6

UniProtKB/TrEMBL

A6JX49, G3V7F3

Conserved Domains (3) summary

cl17735
Location:100 → 159

VWC; von Willebrand factor type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

pfam19035
Location:194 → 237

TSP1_CCN; CCN3 Nov like TSP1 domain