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    Vom2r18 vomeronasal 2 receptor, 18 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 286984, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Vom2r18provided by RGD
    Official Full Name
    vomeronasal 2 receptor, 18provided by RGD
    Primary source
    RGD:708409
    See related
    Ensembl:ENSRNOG00000066191 AllianceGenome:RGD:708409
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Vom2r18 in Genome Data Viewer
    Location:
    1q12
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (72566309..72583584)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (63651332..63668610)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (4320230..4337885)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene vomeronasal type-2 receptor 116-like Neighboring gene uncharacterized LOC134485097 Neighboring gene high mobility group protein B1-like Neighboring gene vomeronasal type-2 receptor 116-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A novel family of putative pheromone receptors in mammals with a topographically organized and sexually dimorphic distribution. Herrada G, et al. Cell, 1997 Aug 22. PMID 9288755
    2. V2R gene families degenerated in primates, dog and cow, but expanded in opossum. Young JM, et al. Trends Genet, 2007 May. PMID 17382427
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vomeronasal 2 receptor, 18
    Names
    putative pheromone receptor (Go-VN4)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173318.2 → NP_775440.1  vomeronasal 2 receptor, 18

      See identical proteins and their annotated locations for NP_775440.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1LZ25, O35268
      Related
      ENSRNOP00000064924.1, ENSRNOT00000071544.4
      Conserved Domains (4) summary
      cd06365
      Location:47 → 513
      PBP1_Pheromone_receptor; Ligand-binding domain of the V2R phermone receptor, a member of the family C receptors within the G-protein coupled receptor superfamily
      pfam00003
      Location:607 → 841
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:85 → 480
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:522 → 573
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      72566309..72583584
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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