Serpinh1 serpin family H member 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Serpinh1provided by RGD
Official Full Name: serpin family H member 1provided by RGD
Primary source: RGD:69302
See related: Ensembl:ENSRNOG00000016831 AllianceGenome:RGD:69302
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cbp2; Serpinh2
Summary: Predicted to enable serine-type endopeptidase inhibitor activity and unfolded protein binding activity. Predicted to be involved in collagen fibril organization and negative regulation of endopeptidase activity. Predicted to act upstream of or within chondrocyte development involved in endochondral bone morphogenesis; collagen biosynthetic process; and protein maturation. Predicted to be located in endoplasmic reticulum-Golgi intermediate compartment and membrane raft. Predicted to be active in endoplasmic reticulum. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 10 and preterm premature rupture of the membranes. Orthologous to human SERPINH1 (serpin family H member 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 808.9), Lung (RPKM 806.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (163055630..163063177, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (153643500..153650853, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (164301010..164308306, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

It could be concluded that LF is a promising antifibrotic drug and could be considered as one of the HSP47 inhibitors but SM is still more potent
Title: Heat shock protein 47 as indispensible participant in liver fibrosis: Possible protective effect of lactoferrin.
The results suggest that Hsp47 turnover may increase during heat stress or that Hsp47 consumption exceeds its production.
Title: Evaluation of Hsp47 expression in heat-stressed rat myocardial cells in vitro and in vivo.
miR-29b down-regulates heat shock protein 47 and LOX expression.
Title: MiR-29b inhibits collagen maturation in hepatic stellate cells through down-regulating the expression of HSP47 and lysyl oxidase.
HSP47 specifically modulates TGF-beta1-induced extracellular matrix protein synthesis in HK-2 cells
Title: HSP47 regulates ECM accumulation in renal proximal tubular cells induced by TGF-β1 through ERK1/2 and JNK MAPK pathways.
Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction.
Title: Heat shock protein 47 (HSP47) antisense oligonucleotides reduce cardiac remodeling and improve cardiac function in a rat model of myocardial infarction.
Involvement of HSP47 in progression of peritoneal fibrosis. Inhibition of HSP47 expression might merit further clinical investigation for treatment of peritoneal fibrosis in continuous ambulatory peritoneal dialysis.
Title: Antisense oligonucleotides against collagen-binding stress protein HSP47 suppress peritoneal fibrosis in rats.
expression of HSP47, a collagen-specific molecular chaperone, responds to gravitational changes, including microgravity and hypergravity in vitro and in vivo
Title: The molecular chaperone HSP47 rapidly senses gravitational changes in myoblasts.
Microgravity differentially modulated the expression of the molecular chaperone HSP47 in osteoblasts
Title: Inhibition of HSP70 and a collagen-specific molecular chaperone (HSP47) expression in rat osteoblasts by microgravity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables collagen binding	IEA Inferred from Electronic Annotation more info
enables collagen binding	TAS Traceable Author Statement more info	PubMed
enables serine-type endopeptidase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within chondrocyte development involved in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within collagen biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in collagen fibril organization	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within collagen fibril organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within protein maturation	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum lumen	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-Golgi intermediate compartment	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in membrane raft	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serpin H1

Names: 47 kDa heat shock protein; GP46; collagen binding protein 2; collagen-binding protein; colligin; serine (or cysteine) peptidase inhibitor, clade H, member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 1; serine (or cysteine) proteinase inhibitor, clade H (heat shock protein 47), member 2; serine (or cysteine) proteinase inhibitor, clade H, member 1; serine proteinase inhibitor, clade H (heat shock protein 47), member 1; serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1); serpin peptidase inhibitor, clade H, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017173.2 → NP_058869.2 serpin H1 precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/Swiss-Prot

P29457

UniProtKB/TrEMBL

A0A0G2JXI0, A6I6G9, Q5RJR9

Conserved Domains (1) summary

cd02046
Location:35 → 416

serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

163055630..163063177 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039107102.2 → XP_038963030.1 serpin H1 isoform X1

UniProtKB/Swiss-Prot

P29457

UniProtKB/TrEMBL

A0A0G2JXI0, A6I6G9, Q5RJR9

Related

ENSRNOP00000070279.1

Conserved Domains (1) summary

cd02046
Location:35 → 416

serpinH1_CBP1; serpin family H member 1, collagen-binding protein 1
XM_063285943.1 → XP_063142013.1 serpin H1 isoform X1

UniProtKB/TrEMBL

A0A0G2JXI0, A6I6G9, Q5RJR9