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    Appl2 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 362860, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Appl2provided by RGD
    Official Full Name
    adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2provided by RGD
    Primary source
    RGD:1563028
    See related
    Ensembl:ENSRNOG00000008174 AllianceGenome:RGD:1563028
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1563028
    Summary
    Predicted to enable phosphatidylinositol binding activity; phosphatidylserine binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including adiponectin-activated signaling pathway; cellular response to growth factor stimulus; and regulation of vesicle-mediated transport. Predicted to be located in cytoplasmic vesicle; nucleus; and ruffle membrane. Predicted to be active in endosome membrane. Orthologous to human APPL2 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 69.7), Testes (RPKM 65.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Appl2 in Genome Data Viewer
    Location:
    7q13
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 7 NC_086025.1 (22019480..22072386)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 7 NC_051342.1 (20135248..20184757)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 7 NC_005106.4 (26256179..26306128)

    Chromosome 7 - NC_086025.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 12 open reading frame 75 Neighboring gene uncharacterized LOC102549680 Neighboring gene WASH complex subunit 4 Neighboring gene integral membrane protein 2A, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Baicalin Modulates APPL2/Glucocorticoid Receptor Signaling Cascade, Promotes Neurogenesis, and Attenuates Emotional and Olfactory Dysfunctions in Chronic Corticosterone-Induced Depression. Gao C, et al. Mol Neurobiol, 2018 Dec. PMID 29675572
    2. Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. Wang B, et al. EMBO Rep, 2018 Apr. PMID 29467283, Free PMC Article
    3. Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. Gao C, et al. Mol Neurobiol, 2018 Jul. PMID 28965332
    4. Distinct Roles for APPL1 and APPL2 in Regulating Toll-like Receptor 4 Signaling in Macrophages. Yeo JC, et al. Traffic, 2016 Sep. PMID 27219021
    5. Appl1 and Appl2 are Expendable for Mouse Development But Are Essential for HGF-Induced Akt Activation and Migration in Mouse Embryonic Fibroblasts. Tan Y, et al. J Cell Physiol, 2016 May. PMID 26445298, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylserine binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in adiponectin-activated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to hepatocyte growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cold acclimation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in diet induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glucose homeostasis ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of cellular response to insulin stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production involved in inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of fatty acid oxidation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glucose import ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of glucose import ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of neural precursor cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of Fc-gamma receptor signaling pathway involved in phagocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cold-induced thermogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of macropinocytosis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of phagocytosis, engulfment ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein homotetramerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein import into nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of fibroblast migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of toll-like receptor 4 signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transforming growth factor beta receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early endosome membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in early phagosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in early phagosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in macropinosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ruffle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DCC-interacting protein 13-beta
    Names
    adapter protein containing PH domain, PTB domain and leucine zipper motif 2
    adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108741.1 → NP_001102211.1  DCC-interacting protein 13-beta

      See identical proteins and their annotated locations for NP_001102211.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473960
      UniProtKB/Swiss-Prot
      B4F779
      UniProtKB/TrEMBL
      A0A8I6A8C2
      Related
      ENSRNOP00000010986.4, ENSRNOT00000010986.6
      Conserved Domains (3) summary
      cd07632
      Location:20 → 234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:480 → 613
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252 → 376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086025.1 Reference GRCr8

      Range
      22019480..22072386
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006241201.5 → XP_006241263.1  DCC-interacting protein 13-beta isoform X1

      UniProtKB/TrEMBL
      A0A8I6A8C2
      Conserved Domains (4) summary
      cd07632
      Location:20 → 234
      BAR_APPL2; The Bin/Amphiphysin/Rvs (BAR) domain of Adaptor protein, Phosphotyrosine interaction, PH domain and Leucine zipper containing 2
      cd13158
      Location:480 → 613
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:252 → 376
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      pfam00169
      Location:278 → 375
      PH; PH domain

    2. XM_039079421.2 → XP_038935349.1  DCC-interacting protein 13-beta isoform X2

      Conserved Domains (3) summary
      cd13158
      Location:337 → 470
      PTB_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif (APPL; also called DCC-interacting protein (DIP)-13alpha) Phosphotyrosine-binding (PTB) domain
      cd13247
      Location:109 → 233
      BAR-PH_APPL; Adaptor protein containing PH domain, PTB domain, and Leucine zipper motif Bin1/amphiphysin/Rvs167 (BAR)-Pleckstrin homology (PH) domain
      cl12013
      Location:1 → 91
      BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B4F779.1 GenPept UniProtKB/Swiss-Prot:B4F779

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