Stc1 stanniocalcin 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Stc1provided by RGD
Official Full Name: stanniocalcin 1provided by RGD
Primary source: RGD:621776
See related: Ensembl:ENSRNOG00000015075 AllianceGenome:RGD:621776
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable identical protein binding activity. Involved in several processes, including cellular response to organic cyclic compound; decidualization; and response to vitamin D. Located in apical plasma membrane and cytoplasm. Orthologous to human STC1 (stanniocalcin 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 65.0), Lung (RPKM 43.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15p11

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (50709439..50720093)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (44299591..44311695)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (50891137..50901791)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy.
Title: Stanniocalcin 1 Inhibits the Inflammatory Response in Microglia and Protects Against Sepsis-Associated Encephalopathy.
Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.
Title: Stanniocalcin-1 is a Modifier of Oxygen-Induced Retinopathy Severity.
Results show that STC1 have an important role in the carbohydrate metabolism regulation, in particular gluconeogenesis from glutamine in the kidney, across the vertebrates.
Title: Stanniocalcin 1 effects on the renal gluconeogenesis pathway in rat and fish.
In this study, we have found that several HIF target genes including STC1 are upregulated in AECs by a submerged condition, that STC1 is regulated by hypoxia and HIF.
Title: Stanniocalcin-1 is induced by hypoxia inducible factor in rat alveolar epithelial cells.
AVP-mediated elevations in STC-1 gene expression are wholly dependent on functional COX-2 activity.
Title: Cyclooxygenase-2 mediates induction of the renal stanniocalcin-1 gene by arginine vasopressin.
Stanniocalcin-1 (STC-1) within the subfornical organ may act in a paracrine/autocrine manner to modulate the neuronal responses to blood-borne angiotensin II.
Title: Stanniocalcin-1 in the subfornical organ inhibits the dipsogenic response to angiotensin II.
STC1 gene induction proceeds through cyclic AMP and ERK1/2, independently of protein kinase A, the canonical cAMP effector.
Title: STC1 induction by PACAP is mediated through cAMP and ERK1/2 but not PKA in cultured cortical neurons.
Endogenous STC-1 signaling in nucleus solitarius is involved in regulating the excitability of neurons functioning as components of the baroreceptor reflex controlling arterial pressure.
Title: Effects of the calcium-regulating glycoprotein hormone stanniocalcin-1 within the nucleus of the solitary tract on arterial pressure and the baroreceptor reflex.
the inner medullary STC-1 gene is differentially regulated in rat and mouse by arginine vasopressin and angiotensin II
Title: Vasopressin controls stanniocalcin-1 gene expression in rat and mouse kidney.
The findings are therefore indicative of cortical and medullary STC-1 having separate roles in the renal control of extracellular fluid balance.
Title: The renal stanniocalcin-1 gene is differentially regulated by hypertonicity and hypovolemia in the rat.

Submit: New GeneRIF Correction See all GeneRIFs (15)

General gene information

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Markers

D15Got53 (e-PCR)
- UniSTS:111616

D15Wox14 (e-PCR)
- UniSTS:518940

D19Mit9 (e-PCR), detects polymorphism
- UniSTS:119350

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bone development	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to glucocorticoid stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in chondrocyte proliferation	ISO Inferred from Sequence Orthology more info
involved_in decidualization	IEP Inferred from Expression Pattern more info	PubMed
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
involved_in endothelial cell morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in growth plate cartilage axis specification	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	ISO Inferred from Sequence Orthology more info
involved_in intracellular calcium ion homeostasis	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of calcium ion transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_positive_effect negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of endothelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of renal phosphate excretion	ISO Inferred from Sequence Orthology more info
involved_in ossification	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of calcium ion import	ISO Inferred from Sequence Orthology more info
involved_in regulation of cardiac muscle cell contraction	ISO Inferred from Sequence Orthology more info
involved_in regulation of monoatomic anion transport	ISO Inferred from Sequence Orthology more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to vitamin D	IEP Inferred from Expression Pattern more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: stanniocalcin-1

Names: STC-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.