Dync1i1 dynein cytoplasmic 1 intermediate chain 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dync1i1provided by RGD
Official Full Name: dynein cytoplasmic 1 intermediate chain 1provided by RGD
Primary source: RGD:2512
See related: Ensembl:ENSRNOG00000009700 AllianceGenome:RGD:2512
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnci1; Dncic1; IC74-1A; IC74-1B
Summary: Enables microtubule binding activity and microtubule motor activity. Involved in brain development and vesicle transport along microtubule. Located in axon cytoplasm and perinuclear region of cytoplasm. Part of cytoplasmic dynein complex. Colocalizes with piccolo-bassoon transport vesicle. Orthologous to human DYNC1I1 (dynein cytoplasmic 1 intermediate chain 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Brain (RPKM 381.0) and Adrenal (RPKM 137.9) See more
Orthologs: human mouse all
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Genomic context

Location:: 4q21

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (34819313..35132647)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (33852597..34166159)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (30807755..31121097)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the dynein-dynactin interaction proceeds through a disorder-to-order transition
Title: Dynein and dynactin leverage their bivalent character to form a high-affinity interaction.
the intermediate chain of dynein binds to kinesin light chains 1 and 2. The interaction is both direct and specific
Title: A direct interaction between cytoplasmic dynein and kinesin I may coordinate motor activity.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables dynein heavy chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	IBA Inferred from Biological aspect of Ancestor more info
enables dynein light chain binding	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables spectrin binding	IEA Inferred from Electronic Annotation more info
enables spectrin binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in intracellular transport of virus	ISO Inferred from Sequence Orthology more info
involved_in transport along microtubule	IBA Inferred from Biological aspect of Ancestor more info
involved_in vesicle transport along microtubule	IDA Inferred from Direct Assay more info	PubMed
involved_in vesicle transport along microtubule	IEA Inferred from Electronic Annotation more info
involved_in vesicle transport along microtubule	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in axon cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
part_of cytoplasmic dynein complex	IBA Inferred from Biological aspect of Ancestor more info
part_of cytoplasmic dynein complex	IDA Inferred from Direct Assay more info	PubMed
part_of cytoplasmic dynein complex	IEA Inferred from Electronic Annotation more info
part_of cytoplasmic dynein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic ribonucleoprotein granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic ribonucleoprotein granule	ISO Inferred from Sequence Orthology more info
located_in kinetochore	IEA Inferred from Electronic Annotation more info
located_in kinetochore	ISO Inferred from Sequence Orthology more info
located_in kinetochore	ISS Inferred from Sequence or Structural Similarity more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in piccolo-bassoon transport vesicle	IDA Inferred from Direct Assay more info	PubMed
located_in recycling endosome	IEA Inferred from Electronic Annotation more info
located_in recycling endosome	ISO Inferred from Sequence Orthology more info
located_in spindle pole	IEA Inferred from Electronic Annotation more info
located_in spindle pole	ISO Inferred from Sequence Orthology more info
located_in spindle pole	ISS Inferred from Sequence or Structural Similarity more info
located_in vesicle	ISO Inferred from Sequence Orthology more info
located_in vesicle	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: cytoplasmic dynein 1 intermediate chain 1

Names: DH IC-1; Dnci 1; cytoplasmic dynein intermediate chain 1; dynein cytoplasmic 1 intermediate chain 1A; dynein cytoplasmic 1 intermediate chain 1B; dynein cytoplasmic 1 intermediate chain 1C; dynein cytoplasmic 1 intermediate chain 1D; dynein intermediate chain 1, cytosolic; dynein, cytoplasmic, intermediate chain 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_019234.2 → NP_062107.2 cytoplasmic dynein 1 intermediate chain 1

Status: PROVISIONAL

Source sequence(s)

JAXUCZ010000004

UniProtKB/Swiss-Prot

Q63100

UniProtKB/TrEMBL

A6IDT9, G3V792

Related

ENSRNOP00000013184.5, ENSRNOT00000013184.5

Conserved Domains (3) summary

sd00039
Location:344 → 383

7WD40; WD40 repeat [structural motif]

pfam11540
Location:145 → 171

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

cl29593
Location:281 → 604

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

34819313..35132647

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236026.5 → XP_006236088.1 cytoplasmic dynein 1 intermediate chain 1 isoform X1

See identical proteins and their annotated locations for XP_006236088.1

UniProtKB/Swiss-Prot

Q63100

UniProtKB/TrEMBL

A0A173DW29

Conserved Domains (4) summary

COG2319
Location:184 → 596

WD40; WD40 repeat [General function prediction only]

pfam11540
Location:128 → 154

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:327 → 366

7WD40; WD40 repeat [structural motif]

cl02567
Location:264 → 587

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_017592509.3 → XP_017447998.1 cytoplasmic dynein 1 intermediate chain 1 isoform X2

UniProtKB/TrEMBL

A0A173DW30, A6IDU1

Related

ENSRNOP00000092857.1

Conserved Domains (4) summary

COG2319
Location:164 → 576

WD40; WD40 repeat [General function prediction only]

pfam11540
Location:108 → 134

Dynein_IC2; Cytoplasmic dynein 1 intermediate chain 2

sd00039
Location:307 → 346

7WD40; WD40 repeat [structural motif]

cl02567
Location:244 → 567

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...