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    Mpeg1 macrophage expressed 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 64552, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Mpeg1provided by RGD
    Official Full Name
    macrophage expressed 1provided by RGD
    Primary source
    RGD:69275
    See related
    Ensembl:ENSRNOG00000063244 AllianceGenome:RGD:69275
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    P-2; Mpg-1
    Summary
    Predicted to be involved in defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; and pore formation in membrane of other organism. Predicted to be located in phagocytic vesicle. Human ortholog(s) of this gene implicated in primary immunodeficiency disease. Orthologous to human MPEG1 (macrophage expressed 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 829.7), Liver (RPKM 558.1) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    1q43
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (218876848..218881364)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (209452176..209456692)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (228724559..228729054)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor family 5 subfamily A member 3 Neighboring gene pore forming protein-like Neighboring gene deltex E3 ubiquitin ligase 4 Neighboring gene FAM111A pseudogene Neighboring gene FAM111 trypsin like peptidase A like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Single cell analyses reveal specific distribution of anti-bacterial molecule Perforin-2 in human skin and its modulation by wounding and Staphylococcus aureus infection. Strbo N, et al. Exp Dermatol, 2019 Mar. PMID 30609079, Free PMC Article
    2. Perforin-2 is essential for intracellular defense of parenchymal cells and phagocytes against pathogenic bacteria. McCormack RM, et al. Elife, 2015 Sep 24. PMID 26402460, Free PMC Article
    3. Perforin-2 restricts growth of Chlamydia trachomatis in macrophages. Fields KA, et al. Infect Immun, 2013 Aug. PMID 23753625, Free PMC Article
    4. Inhibition of intracellular bacterial replication in fibroblasts is dependent on the perforin-like protein (perforin-2) encoded by macrophage-expressed gene 1. McCormack R, et al. J Innate Immun, 2013. PMID 23257510, Free PMC Article
    5. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables pore-forming activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables wide pore channel activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables wide pore channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in adaptive immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    NOT involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antibacterial innate immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in antigen processing and presentation of exogenous peptide antigen via MHC class I ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-negative bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to Gram-positive bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in defense response to bacterium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in defense response to bacterium ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in defense response to bacterium ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in dendritic cell antigen processing and presentation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in dendritic cell antigen processing and presentation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in endolysosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in phagocytic vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in phagocytic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagocytic vesicle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in phagolysosome membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in phagolysosome membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    macrophage-expressed gene 1 protein
    Names
    perforin-2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001305460.1 → NP_001292389.1  macrophage-expressed gene 1 protein precursor

      See identical proteins and their annotated locations for NP_001292389.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI511268, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9WV57
      UniProtKB/TrEMBL
      A0A8I6AL73, A6I0D5
      Conserved Domains (1) summary
      pfam01823
      Location:132 → 348
      MACPF; MAC/Perforin domain

    2. NM_022617.2 → NP_072139.2  macrophage-expressed gene 1 protein precursor

      See identical proteins and their annotated locations for NP_072139.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
      Source sequence(s)
      AI511268, JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q9WV57
      UniProtKB/TrEMBL
      A0A8I6AL73, A6I0D5
      Conserved Domains (1) summary
      pfam01823
      Location:132 → 348
      MACPF; MAC/Perforin domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      218876848..218881364
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008760261.2 → XP_008758483.1  macrophage-expressed gene 1 protein isoform X1

      See identical proteins and their annotated locations for XP_008758483.1

      UniProtKB/Swiss-Prot
      Q9WV57
      UniProtKB/TrEMBL
      A0A8I6AL73, A6I0D5
      Related
      ENSRNOP00000095321.1, ENSRNOT00000094170.1
      Conserved Domains (1) summary
      pfam01823
      Location:132 → 348
      MACPF; MAC/Perforin domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9WV57.2 GenPept UniProtKB/Swiss-Prot:Q9WV57

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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