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    Pcmtd1 protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 366300, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Pcmtd1provided by RGD
    Official Full Name
    protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1provided by RGD
    Primary source
    RGD:1586096
    See related
    Ensembl:ENSRNOG00000005730 AllianceGenome:RGD:1586096
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1307986
    Summary
    Predicted to enable protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Predicted to be involved in protein methylation. Predicted to be active in cytoplasm. Orthologous to human PCMTD1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 355.2), Spleen (RPKM 318.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pcmtd1 in Genome Data Viewer
    Location:
    5q11
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (17071629..17143803, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (12284711..12355680, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (12132657..12204376, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene glutamic-oxaloacetic transaminase 2, pseudogene 2 Neighboring gene uncharacterized LOC120102811 Neighboring gene TOR signaling pathway regulator, pseudogene 2 Neighboring gene ribosomal protein S15, pseudogene 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    NOT enables S-adenosylmethionine-dependent methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul5-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein-L-isoaspartate O-methyltransferase domain-containing protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001257345.1 → NP_001244274.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1

      See identical proteins and their annotated locations for NP_001244274.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000005
      UniProtKB/TrEMBL
      A6JFH4, D3ZPI9, D4A629
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      17071629..17143803 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593529.3 → XP_017449018.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6JFH5
      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    2. XM_039110458.2 → XP_038966386.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6JFH5
      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    3. XM_039110459.2 → XP_038966387.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6JFH5
      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]

    4. XM_039110457.2 → XP_038966385.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X1

      UniProtKB/TrEMBL
      A6JFH4, D3ZPI9, D4A629
      Conserved Domains (1) summary
      pfam01135
      Location:11 → 219
      PCMT; Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT)

    5. XM_008763515.4 → XP_008761737.1  protein-L-isoaspartate O-methyltransferase domain-containing protein 1 isoform X2

      UniProtKB/TrEMBL
      A6JFH5
      Conserved Domains (1) summary
      COG2518
      Location:5 → 44
      Pcm; Protein-L-isoaspartate O-methyltransferase [Posttranslational modification, protein turnover, chaperones]
    Nucleotide Protein Strain
    Heading Accession and Version

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