Apeh acylaminoacyl-peptide hydrolase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Apehprovided by RGD
Official Full Name: acylaminoacyl-peptide hydrolaseprovided by RGD
Primary source: RGD:2125
See related: Ensembl:ENSRNOG00000029572 AllianceGenome:RGD:2125
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Apeh14; Apeh17
Summary: Predicted to enable identical protein binding activity; omega peptidase activity; and serine-type endopeptidase activity. Predicted to be involved in amyloid-beta metabolic process and proteolysis. Predicted to be located in cytosol and nuclear membrane. Orthologous to human APEH (acylaminoacyl-peptide hydrolase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 180.0), Spleen (RPKM 167.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q32

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (117652390..117661502, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (108773791..108782903, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (116862664..116871776, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ACPH protein levels are significantly increased at the synapse; ACPH is preferentially located at the pre-synaptic side
Title: Synaptic localization of acylpeptide hydrolase in adult rat telencephalon.

Submit: New GeneRIF Correction

General gene information

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Markers

d8arb20 (e-PCR)
- UniSTS:122385

RH132558 (e-PCR)
- UniSTS:215841

D8Wox5 (e-PCR)
- UniSTS:239944

RH94462 (e-PCR)
- UniSTS:119710

D8Wox7 (e-PCR)
- UniSTS:119227

D8Wox11 (e-PCR)
- UniSTS:228314

D8Wox11 (e-PCR)
- UniSTS:119279

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables omega peptidase activity	IEA Inferred from Electronic Annotation more info
enables omega peptidase activity	ISO Inferred from Sequence Orthology more info
enables serine-type endopeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type endopeptidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in amyloid-beta metabolic process	IEA Inferred from Electronic Annotation more info
involved_in amyloid-beta metabolic process	ISO Inferred from Sequence Orthology more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: acylamino-acid-releasing enzyme

Names: AARE; APH; N-acylaminoacyl-peptide hydrolase; acyl-peptide hydrolase; acylaminoacyl-peptidase; acylpeptide hydrolase

NP_036632.1

EC 3.4.19.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012500.1 → NP_036632.1 acylamino-acid-releasing enzyme

See identical proteins and their annotated locations for NP_036632.1

Status: PROVISIONAL

Source sequence(s)

J04733

UniProtKB/Swiss-Prot

P13676, P14320, P70479

UniProtKB/TrEMBL

A6I335, B2GVB7

Related

ENSRNOP00000043843.3, ENSRNOT00000045410.4

Conserved Domains (2) summary

pfam00561
Location:501 → 714

Abhydrolase_1; alpha/beta hydrolase fold

cl21494
Location:510 → 707

Abhydrolase; alpha/beta hydrolases