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    Dnase1 deoxyribonuclease 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 25633, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Dnase1provided by RGD
    Official Full Name
    deoxyribonuclease 1provided by RGD
    Primary source
    RGD:2510
    See related
    Ensembl:ENSRNOG00000006873 AllianceGenome:RGD:2510
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables deoxyribonuclease I activity. Predicted to be involved in several processes, including DNA catabolic process, endonucleolytic; neutrophil activation involved in immune response; and regulation of neutrophil mediated cytotoxicity. Predicted to be located in cytoplasmic vesicle; extracellular region; and nuclear envelope. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in systemic lupus erythematosus. Orthologous to human DNASE1 (deoxyribonuclease 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 763.8) and Thymus (RPKM 17.1) See more
    Orthologs
    human mouse all
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    Genomic context

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    See Dnase1 in Genome Data Viewer
    Location:
    10q12
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (12005305..12030615, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (11498930..11505151, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (11757681..11760672, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120095034 Neighboring gene uncharacterized LOC120095035 Neighboring gene CREB binding protein Neighboring gene TNF receptor-associated protein 1 Neighboring gene SLX4 structure-specific endonuclease subunit Neighboring gene NLR family, CARD domain containing 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity. Fahmi T, et al. Int J Mol Sci, 2020 Nov 17. PMID 33212932, Free PMC Article
    2. Identification and expression of deoxyribonuclease (DNase) I alternative transcripts in the rat. Basnakian AG, et al. Gene, 2002 May 1. PMID 12036587
    3. DNase I primary transcript is alternatively spliced in both normal and apoptotic cells: no evidence of up-regulation in apoptosis. Liu QY, et al. DNA Cell Biol, 1997 Aug. PMID 9303433
    4. Characterization of the endogenous deoxyribonuclease involved in nuclear DNA degradation during apoptosis (programmed cell death). Peitsch MC, et al. EMBO J, 1993 Jan. PMID 8428592, Free PMC Article
    5. Nucleotide sequence of a full length cDNA clone encoding the deoxyribonuclease I from the rat parotid gland. Polzar B, et al. Nucleic Acids Res, 1990 Dec 11. PMID 2263485, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity.
      Title: DNase I Induces Other Endonucleases in Kidney Tubular Epithelial Cells by Its DNA-Degrading Activity.
    2. results show that the chief cells of the stomach produce DNase I
      Title: DNase I is present in the chief cells of human and rat stomachs.
    3. A comparison of the expression and transport of DNAse1 from rats and DNAse1L3 from mice is reported.
      Title: Comparative characterization of rat deoxyribonuclease 1 (Dnase1) and murine deoxyribonuclease 1-like 3 (Dnase1l3).
    Submit: New GeneRIF Correction

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC108543

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA nuclease activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables deoxyribonuclease I activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables deoxyribonuclease I activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neutrophil activation involved in immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil activation involved in immune response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of acute inflammatory response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of acute inflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    involved_in regulation of neutrophil mediated cytotoxicity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neutrophil mediated cytotoxicity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear envelope IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in zymogen granule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    deoxyribonuclease-1
    Names
    DNase I
    deoxyribonuclease I
    NP_037229.1
    XP_038941220.1
    XP_038941221.1
    XP_063124552.1
    XP_063124553.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013097.2 → NP_037229.1  deoxyribonuclease-1 precursor

      See identical proteins and their annotated locations for NP_037229.1

      Status: PROVISIONAL

      Source sequence(s)
      AF397150
      UniProtKB/Swiss-Prot
      P21704, Q5FVU6
      UniProtKB/TrEMBL
      A6K4T9
      Related
      ENSRNOP00000009283.3, ENSRNOT00000009283.5
      Conserved Domains (1) summary
      smart00476
      Location:20 → 282
      DNaseIc; deoxyribonuclease I

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      12005305..12030615 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268483.1 → XP_063124553.1  deoxyribonuclease-1 isoform X2

      UniProtKB/Swiss-Prot
      P21704, Q5FVU6
      UniProtKB/TrEMBL
      A6K4T9

    2. XM_039085293.2 → XP_038941221.1  deoxyribonuclease-1 isoform X1

      Conserved Domains (1) summary
      smart00476
      Location:20 → 272
      DNaseIc; deoxyribonuclease I

    3. XM_039085292.2 → XP_038941220.1  deoxyribonuclease-1 isoform X1

      Conserved Domains (1) summary
      smart00476
      Location:20 → 272
      DNaseIc; deoxyribonuclease I

    4. XM_063268482.1 → XP_063124552.1  deoxyribonuclease-1 isoform X2

      UniProtKB/Swiss-Prot
      P21704, Q5FVU6
      UniProtKB/TrEMBL
      A6K4T9
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P21704.1 GenPept UniProtKB/Swiss-Prot:P21704

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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