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    Mmp10 matrix metallopeptidase 10 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 117061, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Mmp10provided by RGD
    Official Full Name
    matrix metallopeptidase 10provided by RGD
    Primary source
    RGD:620192
    See related
    Ensembl:ENSRNOG00000032832 AllianceGenome:RGD:620192
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    SL-2
    Summary
    Predicted to enable metalloendopeptidase activity. Predicted to be involved in collagen catabolic process and extracellular matrix organization. Predicted to act upstream of or within regulation of cell migration. Predicted to be located in extracellular matrix and extracellular region. Orthologous to human MMP10 (matrix metallopeptidase 10). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    8q11
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (12974707..12982613)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (4689840..4697748)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (5734348..5742243)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene matrix metallopeptidase 3 Neighboring gene matrix metallopeptidase 1 Neighboring gene matrix metallopeptidase 8 Neighboring gene matrix metallopeptidase 27

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats. Takamura Y, et al. Mol Vis, 2013. PMID 24339723, Free PMC Article
    2. Sequences coding for part of oncogene-induced transin are highly conserved in a related rat gene. Breathnach R, et al. Nucleic Acids Res, 1987 Feb 11. PMID 3547333, Free PMC Article
    3. Molecular cloning and characterization of v-mos-activated transformation-associated proteins. Chan JC, et al. J Biol Chem, 1992 Jan 15. PMID 1370458
    4. Matrix metalloproteinases: discrete elevations in essential hypertension and hypertensive end-stage renal disease. Friese RS, et al. Clin Exp Hypertens, 2009 Oct. PMID 19886850, Free PMC Article
    5. Transformation of normal rat kidney cells by v-K-ras enhances expression of transin 2 and an S-100-related calcium-binding protein. De Vouge MW, et al. Oncogene, 1992 Jan. PMID 1741158

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
      Title: Elevated expression of cellular SYNE1, MMP10, and GTPase1 and their regulatory role in hepatocellular carcinoma progression.
    2. MMP-10 modulates corneal epithelial wound healing.
      Title: Aldose reductase inhibitor counteracts the enhanced expression of matrix metalloproteinase-10 and improves corneal wound healing in galactose-fed rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables metalloendopeptidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metalloendopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in collagen catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in extracellular matrix organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    stromelysin-2
    Names
    matrix metalloproteinase-10
    transformation-associated protein 34A
    transin-2
    NP_598198.2
    XP_038936637.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_133514.2 → NP_598198.2  stromelysin-2 precursor

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/Swiss-Prot
      P07152
      UniProtKB/TrEMBL
      A6JN35, G3V788
      Related
      ENSRNOP00000013118.3, ENSRNOT00000013119.5
      Conserved Domains (3) summary
      cd00094
      Location:286 → 476
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:108 → 264
      Peptidase_M10; Matrixin
      pfam01471
      Location:33 → 87
      PG_binding_1; Putative peptidoglycan binding domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      12974707..12982613
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039080709.1 → XP_038936637.1  stromelysin-2 isoform X1

      UniProtKB/Swiss-Prot
      P07152
      Conserved Domains (3) summary
      cd00094
      Location:285 → 475
      HX; Hemopexin-like repeats.; Hemopexin is a heme-binding protein that transports heme to the liver. Hemopexin-like repeats occur in vitronectin and some matrix metalloproteinases family (matrixins). The HX repeats of some matrixins bind tissue inhibitor of ...
      pfam00413
      Location:108 → 264
      Peptidase_M10; Matrixin
      pfam01471
      Location:33 → 87
      PG_binding_1; Putative peptidoglycan binding domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P07152.1 GenPept UniProtKB/Swiss-Prot:P07152

    Gene LinkOut

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