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    Tmem176b transmembrane protein 176B [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171411, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Tmem176bprovided by RGD
    Official Full Name
    transmembrane protein 176Bprovided by RGD
    Primary source
    RGD:708403
    See related
    Ensembl:ENSRNOG00000008465 AllianceGenome:RGD:708403
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Lr8; Torid
    Summary
    Predicted to be involved in negative regulation of dendritic cell differentiation. Predicted to be located in nuclear membrane. Predicted to be integral component of membrane. Orthologous to human TMEM176B (transmembrane protein 176B). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 1548.0), Liver (RPKM 1003.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (79097808..79105263, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (77766928..77774740, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (78450724..78458600, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 5 Neighboring gene transmembrane protein 176A Neighboring gene amine oxidase, copper containing 1 Neighboring gene DAB2 interacting protein, pseudogene 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. Louvet C, et al. Am J Transplant, 2005 Sep. PMID 16095493
    2. Tmem176B and Tmem176A are associated with the immature state of dendritic cells. Condamine T, et al. J Leukoc Biol, 2010 Sep. PMID 20501748
    3. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. Lurton J, et al. Am J Respir Cell Mol Biol, 1999 Feb. PMID 9922225
    4. Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis. Na CH, et al. J Proteome Res, 2012 Sep 7. PMID 22871113, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. TORID may be involved in the control of DC maturation and may, therefore, play a role in the induction or maintenance of allograft tolerance
      Title: Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC72697

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    acts_upstream_of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of dendritic cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of dendritic cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transmembrane protein 176B
    Names
    TORID
    tolerance-related and induced transcript protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270589.1 → NP_001257518.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257518.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    2. NM_001270590.1 → NP_001257519.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257519.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    3. NM_001270591.1 → NP_001257520.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257520.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, FN804490, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Related
      ENSRNOP00000011327.3, ENSRNOT00000011327.7
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    4. NM_001270592.1 → NP_001257521.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257521.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, FM086181, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    5. NM_001270593.1 → NP_001257522.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257522.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, FM070640, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    6. NM_001270594.1 → NP_001257523.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_001257523.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, FM070640, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    7. NM_134390.3 → NP_599217.1  transmembrane protein 176B

      See identical proteins and their annotated locations for NP_599217.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All seven variants encode the same protein.
      Source sequence(s)
      BC059116, JAXUCZ010000004
      UniProtKB/Swiss-Prot
      Q925D4
      UniProtKB/TrEMBL
      A6K0I4, A6K0I5
      Conserved Domains (1) summary
      pfam04103
      Location:60 → 224
      CD20; CD20-like family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      79097808..79105263 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q925D4.1 GenPept UniProtKB/Swiss-Prot:Q925D4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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