Parm1 prostate androgen-regulated mucin-like protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Parm1provided by RGD
Official Full Name: prostate androgen-regulated mucin-like protein 1provided by RGD
Primary source: RGD:708342
See related: Ensembl:ENSRNOG00000002579 AllianceGenome:RGD:708342
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cipar1; PARM-1; CIPAR-1
Summary: Involved in positive regulation of telomerase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in Golgi apparatus; endosome; and plasma membrane. Orthologous to human PARM1 (prostate androgen-regulated mucin-like protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Heart (RPKM 374.4), Thymus (RPKM 118.2) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (16752541..16861570, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (16468309..16577339, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (17972914..18076870, complement)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis.
Title: PARM1 Drives Smooth Muscle Cell Proliferation in Pulmonary Arterial Hypertension via AKT/FOXO3A Axis.
PARM1 contributes to ovulation and/or luteal function by acting as a novel regulator of progesterone metabolism.
Title: Prostate androgen-regulated mucin-like protein 1: a novel regulator of progesterone metabolism.
PARM-1 is a novel ER transmembrane molecule involved in cardiac remodeling in hypertensive heart disease
Title: PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.
PARM-1 is an ER protein in cardiac myocytes, whose expression is enhanced by ER stress and in the hearts of hypertensive heart disease model of Dahl salt-sensitive rats. PARM-1 has a protective role against ER stress-induced apoptosis in cardiac myocytes.
Title: PARM-1 is an endoplasmic reticulum molecule involved in endoplasmic reticulum stress-induced apoptosis in rat cardiac myocytes.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Component	Evidence Code	Pubs
is_active_in Golgi apparatus	IBA Inferred from Biological aspect of Ancestor more info
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in Golgi apparatus	ISS Inferred from Sequence or Structural Similarity more info
located_in Golgi membrane	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in early endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in early endosome	IEA Inferred from Electronic Annotation more info
located_in early endosome	ISO Inferred from Sequence Orthology more info
located_in early endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
is_active_in late endosome	IBA Inferred from Biological aspect of Ancestor more info
located_in late endosome	IEA Inferred from Electronic Annotation more info
located_in late endosome	ISO Inferred from Sequence Orthology more info
located_in late endosome	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: prostate androgen-regulated mucin-like protein 1 homolog

Names: castration-induced prostatic apoptosis-related protein 1; prostatic androgen-repressed message 1 protein; prostatic androgen-repressed message-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173114.2 → NP_775137.2 prostate androgen-regulated mucin-like protein 1 homolog precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000014

UniProtKB/Swiss-Prot

Q6P9X9, Q9Z0P0

UniProtKB/TrEMBL

A0A8I5ZJE2, A6KKC6

Related

ENSRNOP00000077133.1, ENSRNOT00000105204.1

Conserved Domains (1) summary

pfam17061
Location:15 → 296

PARM