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    Kansl1 KAT8 regulatory NSL complex subunit 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 360642, updated on 2-May-2024

    Summary

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    Official Symbol
    Kansl1provided by RGD
    Official Full Name
    KAT8 regulatory NSL complex subunit 1provided by RGD
    Primary source
    RGD:1311429
    See related
    Ensembl:ENSRNOG00000053680 AllianceGenome:RGD:1311429
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1311429
    Summary
    Predicted to enable histone acetyltransferase binding activity. Predicted to be involved in histone H4-K16 acetylation; histone H4-K5 acetylation; and histone H4-K8 acetylation. Predicted to be located in nucleoplasm. Predicted to be part of MLL1 complex and NSL complex. Human ortholog(s) of this gene implicated in Koolen de Vries syndrome. Orthologous to human KANSL1 (KAT8 regulatory NSL complex subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 168.0), Spleen (RPKM 137.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kansl1 in Genome Data Viewer
    Location:
    10q32.1
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (89737637..89868620, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (89237667..89368735, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (92388045..92517449, complement)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene microtubule-associated protein tau Neighboring gene uncharacterized LOC134480886 Neighboring gene uncharacterized LOC134480887 Neighboring gene small nucleolar RNA SNORA21 Neighboring gene cell division cycle 27 Neighboring gene myosin, light chain 4 Neighboring gene glutathione S-transferase pi 1, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Subunit composition and substrate specificity of a MOF-containing histone acetyltransferase distinct from the male-specific lethal (MSL) complex. Cai Y, et al. J Biol Chem, 2010 Feb 12. PMID 20018852, Free PMC Article
    2. Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF. Dou Y, et al. Cell, 2005 Jun 17. PMID 15960975
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables histone acetyltransferase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of mitochondrial transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of MLL1 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of NSL complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of NSL complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of histone acetyltransferase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KAT8 regulatory NSL complex subunit 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427727.1 → NP_001414656.1  KAT8 regulatory NSL complex subunit 1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/TrEMBL
      A0A8I6AJF7

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      89737637..89868620 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063269456.1 → XP_063125526.1  KAT8 regulatory NSL complex subunit 1 isoform X4

    2. XM_063269453.1 → XP_063125523.1  KAT8 regulatory NSL complex subunit 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6ACX3

    3. XM_063269454.1 → XP_063125524.1  KAT8 regulatory NSL complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      A0A0G2K8Z6

    4. XM_063269452.1 → XP_063125522.1  KAT8 regulatory NSL complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A8I6AJF7
    Nucleotide Protein Strain
    Heading Accession and Version

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