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    Plekha8 pleckstrin homology domain containing A8 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 500132, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Plekha8provided by RGD
    Official Full Name
    pleckstrin homology domain containing A8provided by RGD
    Primary source
    RGD:1563940
    See related
    Ensembl:ENSRNOG00000009971 AllianceGenome:RGD:1563940
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    FAPP-2; RGD1563940
    Summary
    Predicted to enable several functions, including identical protein binding activity; lipid transfer activity; and phospholipid binding activity. Predicted to be involved in ER to Golgi ceramide transport and intermembrane lipid transfer. Predicted to be located in nucleoplasm and trans-Golgi network. Predicted to be active in cytosol. Orthologous to human PLEKHA8 (pleckstrin homology domain containing A8). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 55.4), Testes (RPKM 46.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Plekha8 in Genome Data Viewer
    Location:
    4q24
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85053765..85104376)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (83723470..83774081)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (84770294..84820887)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene secernin 1 Neighboring gene uncharacterized LOC102553885 Neighboring gene FKBP prolyl isomerase 14 Neighboring gene translocase of outer mitochondrial membrane 7, pseudogene 3 Neighboring gene uncharacterized LOC134486771 Neighboring gene maturin, neural progenitor differentiation regulator homolog Neighboring gene uncharacterized LOC100909941

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Glycosphingolipid synthesis requires FAPP2 transfer of glucosylceramide. D'Angelo G, et al. Nature, 2007 Sep 6. PMID 17687330
    2. Golgi protein FAPP2 tubulates membranes. Cao X, et al. Proc Natl Acad Sci U S A, 2009 Dec 15. PMID 19940249, Free PMC Article
    3. FAPPs control Golgi-to-cell-surface membrane traffic by binding to ARF and PtdIns(4)P. Godi A, et al. Nat Cell Biol, 2004 May. PMID 15107860
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables ceramide 1-phosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide 1-phosphate transfer activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ceramide binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ceramide binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycolipid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycolipid binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables glycolipid transfer activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glycolipid transfer activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables phosphatidylinositol-4-phosphate binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in ER to Golgi ceramide transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ER to Golgi ceramide transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ceramide 1-phosphate transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ceramide transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glycolipid transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in intermembrane lipid transfer IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in lipid transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in trans-Golgi network ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    pleckstrin homology domain-containing family A member 8
    Names
    PH domain-containing family A member 8
    phosphatidylinositol-four-phosphate adapter protein 2
    phosphoinositol 4-phosphate adapter protein 2
    pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001109235.2 → NP_001102705.1  pleckstrin homology domain-containing family A member 8

      See identical proteins and their annotated locations for NP_001102705.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000004
      UniProtKB/Swiss-Prot
      D3ZY60
      Related
      ENSRNOP00000013528.5, ENSRNOT00000013528.7
      Conserved Domains (3) summary
      cd01247
      Location:1 → 100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:1 → 93
      PH; PH domain
      pfam08718
      Location:334 → 471
      GLTP; Glycolipid transfer protein (GLTP)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      85053765..85104376
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039108138.2 → XP_038964066.1  pleckstrin homology domain-containing family A member 8 isoform X1

      Conserved Domains (1) summary
      cd01247
      Location:1 → 100
      PH_FAPP1_FAPP2; Four phosphate adaptor protein 1 and 2 Pleckstrin homology (PH) domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3ZY60.1 GenPept UniProtKB/Swiss-Prot:D3ZY60

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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