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    Heca hdc homolog, cell cycle regulator [ Rattus norvegicus (Norway rat) ]

    Gene ID: 308624, updated on 4-Apr-2024

    Summary

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    Official Symbol
    Hecaprovided by RGD
    Official Full Name
    hdc homolog, cell cycle regulatorprovided by RGD
    Primary source
    RGD:1304818
    See related
    Ensembl:ENSRNOG00000060972 AllianceGenome:RGD:1304818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in negative regulation of mitotic cell cycle. Predicted to be located in cytoplasm and nucleus. Orthologous to human HECA (hdc homolog, cell cycle regulator). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 148.0), Thymus (RPKM 133.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Heca in Genome Data Viewer
    Location:
    1p12
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (14345306..14395226, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (12525445..12575358, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (13036909..13050644, complement)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene developmental pluripotency-associated protein 5A-like Neighboring gene taxilin beta Neighboring gene heat shock protein 90 alpha family class A member 1, pseudogene 2 Neighboring gene ABRA C-terminal like Neighboring gene RALBP1 associated Eps domain containing 1 Neighboring gene epithelial cell transforming 2 like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. The human HECA interacts with cyclins and CDKs to antagonize Wnt-mediated proliferation and chemoresistance of head and neck cancer cells. Dowejko A, et al. Exp Cell Res, 2012 Mar 10. PMID 22100912
    2. The human homolog of the Drosophila headcase protein slows down cell division of head and neck cancer cells. Dowejko A, et al. Carcinogenesis, 2009 Oct. PMID 19643820
    3. Defining the membrane proteome of NK cells. Ghosh D, et al. J Mass Spectrom, 2010 Jan. PMID 19946888

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in negative regulation of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    headcase protein homolog
    Names
    headcase homolog

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107514.3 → NP_001100984.2  headcase protein homolog

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/TrEMBL
      F1M590
      Related
      ENSRNOP00000073877.2, ENSRNOT00000081259.2

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      14345306..14395226 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039112456.2 → XP_038968384.1  headcase protein homolog isoform X3

      Conserved Domains (1) summary
      pfam15353
      Location:93 → 191
      HECA; Headcase protein family homolog

    2. XM_039112451.2 → XP_038968379.1  headcase protein homolog isoform X1

      Conserved Domains (2) summary
      pfam15353
      Location:93 → 191
      HECA; Headcase protein family homolog
      pfam16002
      Location:340 → 401
      Headcase; Headcase protein

    3. XM_063262262.1 → XP_063118332.1  headcase protein homolog isoform X2

    RNA

    1. XR_010052133.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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