Ptpn12 protein tyrosine phosphatase, non-receptor type 12 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Ptpn12provided by RGD
Official Full Name: protein tyrosine phosphatase, non-receptor type 12provided by RGD
Primary source: RGD:620894
See related: Ensembl:ENSRNOG00000013135 AllianceGenome:RGD:620894
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Ptpg1; RKPTP
Summary: Enables protein tyrosine phosphatase activity. Involved in tissue regeneration. Predicted to be located in cytosol and podosome. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in colorectal cancer. Orthologous to human PTPN12 (protein tyrosine phosphatase non-receptor type 12). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 148.8), Spleen (RPKM 103.8) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q11

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (14913071..14985084)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (14020997..14092931)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (10631129..10702390)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

data demonstrate PTP-PEST expression in adrenal ZF and its regulation by ACTH/PKA and also suggest an ACTH-induced PTP-PEST-paxillin interaction
Title: ACTH Modulates PTP-PEST Activity and Promotes Its Interaction With Paxillin.
PTP-PEST is involved in the regulation of FcepsilonRI-mediated mast cell activation through at least two different processes represented by PTP activity-dependent and -independent pathways.
Title: Protein tyrosine phosphatase-PEST (PTP-PEST) regulates mast cell-activating signals in PTP activity-dependent and -independent manners.
Data suggest that IGF-I induces smooth muscle cell motility by increasing phosphotyrosine levels of p130(cas) and activating Rac1, and that nitric oxide decreases motility by activating PTP-PEST
Title: Nitric oxide attenuates IGF-I-induced aortic smooth muscle cell motility by decreasing Rac1 activity: essential role of PTP-PEST and p130cas.

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General gene information

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Markers

PTPN12_1837 (e-PCR)
- UniSTS:280939

RH143589 (e-PCR)
- UniSTS:232835

GDB:305494 (e-PCR)
- UniSTS:156412

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables SH3 domain binding	ISO Inferred from Sequence Orthology more info
enables non-membrane spanning protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	ISO Inferred from Sequence Orthology more info
enables protein tyrosine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein tyrosine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein tyrosine phosphatase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to epidermal growth factor stimulus	ISO Inferred from Sequence Orthology more info
involved_in protein dephosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of epidermal growth factor receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in tissue regeneration	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in podosome	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: tyrosine-protein phosphatase non-receptor type 12

NP_476456.2

EC 3.1.3.48

XP_006235930.1

EC 3.1.3.48

XP_006235932.1

EC 3.1.3.48

XP_063141493.1

EC 3.1.3.48

XP_063141494.1

EC 3.1.3.48

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_057115.2 → NP_476456.2 tyrosine-protein phosphatase non-receptor type 12

See identical proteins and their annotated locations for NP_476456.2

Status: VALIDATED

Source sequence(s)

BP489229, CK367675, CV102923, CX570435, D38072, DY560717

UniProtKB/TrEMBL

A0A8I5ZN71, A6K5C4, G3V7Q4

Related

ENSRNOP00000017907.5, ENSRNOT00000017907.6

Conserved Domains (2) summary

smart00194
Location:28 → 292

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:60 → 292

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

14913071..14985084

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006235868.5 → XP_006235930.1 tyrosine-protein phosphatase non-receptor type 12 isoform X1

UniProtKB/TrEMBL

A0A8I5ZN71

Conserved Domains (2) summary

smart00194
Location:28 → 292

PTPc; Protein tyrosine phosphatase, catalytic domain

cd00047
Location:60 → 292

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
XM_063285423.1 → XP_063141493.1 tyrosine-protein phosphatase non-receptor type 12 isoform X2
XM_006235870.3 → XP_006235932.1 tyrosine-protein phosphatase non-receptor type 12 isoform X3

UniProtKB/TrEMBL

A0A8I5ZN71

Conserved Domains (2) summary

cd00047
Location:1 → 173

PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

pfam00102
Location:1 → 173

Y_phosphatase; Protein-tyrosine phosphatase
XM_063285424.1 → XP_063141494.1 tyrosine-protein phosphatase non-receptor type 12 isoform X3