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    Mindy4 MINDY lysine 48 deubiquitinase 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 312365, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Mindy4provided by RGD
    Official Full Name
    MINDY lysine 48 deubiquitinase 4provided by RGD
    Primary source
    RGD:1562590
    See related
    Ensembl:ENSRNOG00000011530 AllianceGenome:RGD:1562590
    Gene type
    protein coding
    RefSeq status
    MODEL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fam188b; RGD1562590
    Summary
    Predicted to enable Lys48-specific deubiquitinase activity. Predicted to be involved in protein K48-linked deubiquitination. Orthologous to human MINDY4 (MINDY lysine 48 deubiquitinase 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 37.9), Kidney (RPKM 33.1) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    4q24
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (85689049..85797553)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (84358660..84469189)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (85427741..85536264)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550746 Neighboring gene indolethylamine N-methyltransferase Neighboring gene aquaporin 1 Neighboring gene growth hormone releasing hormone receptor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cysteine-type deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    probable ubiquitin carboxyl-terminal hydrolase MINDY-4
    Names
    family with sequence similarity 188, member B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      85689049..85797553
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_231787.10 → XP_231787.5  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X2

      See identical proteins and their annotated locations for XP_231787.5

      UniProtKB/TrEMBL
      D3ZJJ0
      Related
      ENSRNOP00000015469.6
      Conserved Domains (1) summary
      pfam13898
      Location:415 → 751
      DUF4205; Domain of unknown function (DUF4205)

    2. XM_039108680.2 → XP_038964608.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X1

      Conserved Domains (1) summary
      pfam13898
      Location:483 → 819
      DUF4205; Domain of unknown function (DUF4205)

    3. XM_063286962.1 → XP_063143032.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X4

    4. XM_039108681.2 → XP_038964609.1  probable ubiquitin carboxyl-terminal hydrolase MINDY-4 isoform X3

      Conserved Domains (1) summary
      pfam13898
      Location:85 → 421
      DUF4205; Domain of unknown function (DUF4205)

    RNA

    1. XR_005503604.2 RNA Sequence

    2. XR_005503605.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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