Mboat1 membrane bound O-acyltransferase domain containing 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mboat1provided by RGD
Official Full Name: membrane bound O-acyltransferase domain containing 1provided by RGD
Primary source: RGD:1565561
See related: Ensembl:ENSRNOG00000027125 AllianceGenome:RGD:1565561
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565521; RGD1565561
Summary: Predicted to enable 1-acylglycerophosphoethanolamine O-acyltransferase activity and 1-acylglycerophosphoserine O-acyltransferase activity. Predicted to be involved in lipid modification; phospholipid metabolic process; and regulation of neuron projection development. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in membrane. Orthologous to human MBOAT1 (membrane bound O-acyltransferase domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 69.7), Kidney (RPKM 50.8) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 17p12

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	17	NC_086035.1 (34540032..34653705, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	17	NC_051352.1 (34331413..34445088, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	17	NC_005116.4 (36061775..36177457, complement)

Chromosome 17 - NC_086035.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

RH128418 (e-PCR)
- UniSTS:211726

AU048745 (e-PCR)
- UniSTS:145195

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 1-acylglycerophosphoethanolamine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables 1-acylglycerophosphoserine O-acyltransferase activity	ISO Inferred from Sequence Orthology more info
enables acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in lipid modification	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylethanolamine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylserine acyl-chain remodeling	ISO Inferred from Sequence Orthology more info
involved_in phospholipid biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in regulation of neuron projection development	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: lysophospholipid acyltransferase 1

NP_001102590.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_038951938.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_038951939.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

XP_063132760.1

EC 2.3.1.23

EC 2.3.1.n6

EC 2.3.1.n7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001109120.1 → NP_001102590.1 lysophospholipid acyltransferase 1

See identical proteins and their annotated locations for NP_001102590.1

Status: PROVISIONAL

Source sequence(s)

CH473977

UniProtKB/TrEMBL

A6J7M5, F1LV18

Related

ENSRNOP00000034823.5, ENSRNOT00000036978.6

Conserved Domains (1) summary

cl00738
Location:21 → 458

MBOAT; MBOAT, membrane-bound O-acyltransferase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086035.1 Reference GRCr8

Range

34540032..34653705 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039096010.2 → XP_038951938.1 lysophospholipid acyltransferase 1 isoform X1

Conserved Domains (1) summary

cl00738
Location:21 → 426

MBOAT; membrane-bound O-acyltransferase family
XM_039096011.2 → XP_038951939.1 lysophospholipid acyltransferase 1 isoform X2

Conserved Domains (1) summary

cl00738
Location:21 → 390

MBOAT; membrane-bound O-acyltransferase family
XM_063276690.1 → XP_063132760.1 lysophospholipid acyltransferase 1 isoform X3