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    Ggact gamma-glutamylamine cyclotransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 290500, updated on 3-Apr-2024

    Summary

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    Official Symbol
    Ggactprovided by RGD
    Official Full Name
    gamma-glutamylamine cyclotransferaseprovided by RGD
    Primary source
    RGD:1304748
    See related
    Ensembl:ENSRNOG00000027040 AllianceGenome:RGD:1304748
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    A2ld1
    Summary
    Predicted to enable gamma-glutamylaminecyclotransferase activity. Predicted to be involved in cellular modified amino acid catabolic process. Predicted to be active in cytosol. Orthologous to human GGACT (gamma-glutamylamine cyclotransferase). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 64.3), Adrenal (RPKM 58.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ggact in Genome Data Viewer
    Location:
    15q25
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (106375924..106406649, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (99969246..99998343, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (109307683..109336779, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ribosomal protein L24, pseudogene 6 Neighboring gene propionyl-CoA carboxylase subunit alpha Neighboring gene transmembrane O-mannosyltransferase targeting cadherins 4 Neighboring gene small nucleolar RNA SNORA44

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Identification and characterization of gamma-glutamylamine cyclotransferase, an enzyme responsible for gamma-glutamyl-epsilon-lysine catabolism. Oakley AJ, et al. J Biol Chem, 2010 Mar 26. PMID 20110353, Free PMC Article
    2. In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine. Principe S, et al. Proteomics, 2013 May. PMID 23533145, Free PMC Article
    3. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. Prunotto M, et al. J Proteomics, 2013 Apr 26. PMID 23376485
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC112665

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables gamma-glutamylaminecyclotransferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables gamma-glutamylaminecyclotransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables gamma-glutamylaminecyclotransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular modified amino acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular modified amino acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular modified amino acid catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    gamma-glutamylaminecyclotransferase
    Names
    AIG2-like domain 1
    AIG2-like domain-containing protein 1
    NP_001020805.2
    NP_001296987.1
    XP_006252574.1
    XP_006252575.1
    XP_006252582.1
    XP_006252583.1
    XP_006252584.1
    XP_038949130.1
    XP_038949131.1
    XP_038949133.1
    XP_063130246.1
    XP_063130247.1
    XP_063130248.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001025634.2 → NP_001020805.2  gamma-glutamylaminecyclotransferase

      See identical proteins and their annotated locations for NP_001020805.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    2. NM_001310058.1 → NP_001296987.1  gamma-glutamylaminecyclotransferase

      See identical proteins and their annotated locations for NP_001296987.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      JAXUCZ010000015
      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      106375924..106406649 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063274178.1 → XP_063130248.1  gamma-glutamylaminecyclotransferase isoform X2

      UniProtKB/TrEMBL
      A6HUM7

    2. XM_006252520.5 → XP_006252582.1  gamma-glutamylaminecyclotransferase isoform X2

      See identical proteins and their annotated locations for XP_006252582.1

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    3. XM_063274176.1 → XP_063130246.1  gamma-glutamylaminecyclotransferase isoform X1

      UniProtKB/TrEMBL
      A0A8L2PXS0

    4. XM_006252512.5 → XP_006252574.1  gamma-glutamylaminecyclotransferase isoform X1

      See identical proteins and their annotated locations for XP_006252574.1

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A0A8L2PXS0
      Conserved Domains (1) summary
      pfam06094
      Location:33 → 144
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    5. XM_039093202.2 → XP_038949130.1  gamma-glutamylaminecyclotransferase isoform X2

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    6. XM_006252521.4 → XP_006252583.1  gamma-glutamylaminecyclotransferase isoform X2

      See identical proteins and their annotated locations for XP_006252583.1

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    7. XM_006252522.5 → XP_006252584.1  gamma-glutamylaminecyclotransferase isoform X2

      See identical proteins and their annotated locations for XP_006252584.1

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    8. XM_006252513.4 → XP_006252575.1  gamma-glutamylaminecyclotransferase isoform X1

      See identical proteins and their annotated locations for XP_006252575.1

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A0A8L2PXS0
      Related
      ENSRNOP00000000118.3
      Conserved Domains (1) summary
      pfam06094
      Location:33 → 144
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    9. XM_039093203.2 → XP_038949131.1  gamma-glutamylaminecyclotransferase isoform X2

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    10. XM_039093205.2 → XP_038949133.1  gamma-glutamylaminecyclotransferase isoform X2

      UniProtKB/Swiss-Prot
      Q4KM86
      UniProtKB/TrEMBL
      A6HUM7
      Conserved Domains (1) summary
      pfam06094
      Location:19 → 149
      GGACT; Gamma-glutamyl cyclotransferase, AIG2-like

    11. XM_063274177.1 → XP_063130247.1  gamma-glutamylaminecyclotransferase isoform X1

      UniProtKB/TrEMBL
      A0A8L2PXS0
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q4KM86.1 GenPept UniProtKB/Swiss-Prot:Q4KM86

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