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    Dennd2c DENN domain containing 2C [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295333, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Dennd2cprovided by RGD
    Official Full Name
    DENN domain containing 2Cprovided by RGD
    Primary source
    RGD:1308197
    See related
    Ensembl:ENSRNOG00000018716 AllianceGenome:RGD:1308197
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1308197
    Summary
    Predicted to enable guanyl-nucleotide exchange factor activity. Predicted to be involved in regulation of catalytic activity. Predicted to be located in nucleoplasm. Orthologous to human DENND2C (DENN domain containing 2C). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Heart (RPKM 60.0), Muscle (RPKM 50.3) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    2q34
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 2 NC_086020.1 (193310822..193378986)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 2 NC_051337.1 (190622357..190690489)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 2 NC_005101.4 (205592348..205660619)

    Chromosome 2 - NC_086020.1Genomic Context describing neighboring genes Neighboring gene NRAS proto-oncogene, GTPase Neighboring gene adenosine monophosphate deaminase 1 Neighboring gene BCAS2, pre-mRNA processing factor Neighboring gene carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Family-wide characterization of the DENN domain Rab GDP-GTP exchange factors. Yoshimura S, et al. J Cell Biol, 2010 Oct 18. PMID 20937701, Free PMC Article
    2. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    DENN domain-containing protein 2C
    Names
    DENN/MADD domain containing 2C

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001191569.1 → NP_001178498.1  DENN domain-containing protein 2C

      See identical proteins and their annotated locations for NP_001178498.1

      Status: VALIDATED

      Source sequence(s)
      BM385166, JAXUCZ010000002
      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Related
      ENSRNOP00000025365.5, ENSRNOT00000025365.6
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086020.1 Reference GRCr8

      Range
      193310822..193378986
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006233071.5 → XP_006233133.1  DENN domain-containing protein 2C isoform X1

      See identical proteins and their annotated locations for XP_006233133.1

      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain

    2. XM_006233069.3 → XP_006233131.1  DENN domain-containing protein 2C isoform X1

      See identical proteins and their annotated locations for XP_006233131.1

      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain

    3. XM_039102070.2 → XP_038957998.1  DENN domain-containing protein 2C isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain

    4. XM_039102069.2 → XP_038957997.1  DENN domain-containing protein 2C isoform X1

      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain

    5. XM_063281634.1 → XP_063137704.1  DENN domain-containing protein 2C isoform X2

    6. XM_006233070.5 → XP_006233132.1  DENN domain-containing protein 2C isoform X1

      See identical proteins and their annotated locations for XP_006233132.1

      UniProtKB/TrEMBL
      A0A0G2JTT3, D3ZX30
      Conserved Domains (3) summary
      smart00801
      Location:810 → 876
      dDENN; Domain always found downstream of DENN domain, found in a variety of signalling proteins
      smart00800
      Location:482 → 571
      uDENN; Domain always found upstream of DENN domain, found in a variety of signalling proteins
      pfam02141
      Location:581 → 765
      DENN; DENN (AEX-3) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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