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    Kmt2e lysine methyltransferase 2E [ Rattus norvegicus (Norway rat) ]

    Gene ID: 311968, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Kmt2eprovided by RGD
    Official Full Name
    lysine methyltransferase 2Eprovided by RGD
    Primary source
    RGD:1309641
    See related
    Ensembl:ENSRNOG00000021614 AllianceGenome:RGD:1309641
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Mll5
    Summary
    Predicted to enable enzyme binding activity and methylated histone binding activity. Predicted to be involved in several processes, including neutrophil activation; positive regulation of G1/S transition of mitotic cell cycle; and positive regulation of nitrogen compound metabolic process. Predicted to be located in nuclear body and transcriptionally active chromatin. Predicted to be part of protein-containing complex. Human ortholog(s) of this gene implicated in autistic disorder and cervical cancer. Orthologous to human KMT2E (lysine methyltransferase 2E (inactive)). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Spleen (RPKM 174.2), Thymus (RPKM 173.9) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Kmt2e in Genome Data Viewer
    Location:
    4q11
    Exon count:
    32
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (12550570..12655329, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (11658218..11727373, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (8187751..8255578, complement)

    Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene small nucleolar RNA SNORD93 Neighboring gene uncharacterized LOC134486545 Neighboring gene SRSF protein kinase 2 Neighboring gene uncharacterized LOC120102473 Neighboring gene U7 small nuclear RNA

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Targeted silencing of MLL5β inhibits tumor growth and promotes gamma-irradiation sensitization in HPV16/18-associated cervical cancers. Nin DS, et al. Mol Cancer Ther, 2014 Nov. PMID 25172963
    2. The Human Mixed Lineage Leukemia 5 (MLL5), a Sequentially and Structurally Divergent SET Domain-Containing Protein with No Intrinsic Catalytic Activity. Mas-Y-Mas S, et al. PLoS One, 2016. PMID 27812132, Free PMC Article
    3. Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study. Lucena-Araujo AR, et al. Br J Haematol, 2014 Aug. PMID 24796963
    4. Solution NMR structure and histone binding of the PHD domain of human MLL5. Lemak A, et al. PLoS One, 2013. PMID 24130829, Free PMC Article
    5. Molecular basis for chromatin binding and regulation of MLL5. Ali M, et al. Proc Natl Acad Sci U S A, 2013 Jul 9. PMID 23798402, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables enzyme binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    NOT enables histone H3 methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables methylated histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables methylated histone binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription coactivator activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in epigenetic regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in erythrocyte differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil activation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neutrophil mediated immunity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of G1/S transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Rpd3L-Expanded complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Set3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of euchromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear body IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    inactive histone-lysine N-methyltransferase 2E
    Names
    histone-lysine N-methyltransferase 2E
    histone-lysine N-methyltransferase MLL5
    lysine (K)-specific methyltransferase 2E
    myeloid/lymphoid or mixed-lineage leukemia 5 (trithorax homolog, Drosophila)
    NP_001094321.2
    XP_063142017.1
    XP_063142018.1
    XP_063142019.1
    XP_063142020.1
    XP_063142021.1
    XP_063142022.1
    XP_063142023.1
    XP_063142024.1
    XP_063142025.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001100851.2 → NP_001094321.2  inactive histone-lysine N-methyltransferase 2E

      Status: PROVISIONAL

      Source sequence(s)
      CK367010, JAXUCZ010000004
      UniProtKB/TrEMBL
      A0A0G2JWF0, A0A8I6ASP1
      Related
      ENSRNOP00000097446.1, ENSRNOT00000075902.3
      Conserved Domains (5) summary
      PHA03247
      Location:1307 → 1612
      PHA03247; large tegument protein UL36; Provisional
      COG1196
      Location:483 → 716
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      PRK03427
      Location:1737 → 1845
      PRK03427; cell division protein ZipA; Provisional
      cd15550
      Location:120 → 163
      PHD_MLL5; PHD finger found in mixed lineage leukemia 5 (MLL5)
      cd19182
      Location:324 → 451
      SET_KMT2E; SET domain found in inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086022.1 Reference GRCr8

      Range
      12550570..12655329 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063285953.1 → XP_063142023.1  inactive histone-lysine N-methyltransferase 2E isoform X3

    2. XM_063285952.1 → XP_063142022.1  inactive histone-lysine N-methyltransferase 2E isoform X2

    3. XM_063285947.1 → XP_063142017.1  inactive histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP1

    4. XM_063285949.1 → XP_063142019.1  inactive histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP1

    5. XM_063285951.1 → XP_063142021.1  inactive histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP1

    6. XM_063285948.1 → XP_063142018.1  inactive histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP1

    7. XM_063285950.1 → XP_063142020.1  inactive histone-lysine N-methyltransferase 2E isoform X1

      UniProtKB/TrEMBL
      A0A8I6ASP1

    8. XM_063285954.1 → XP_063142024.1  inactive histone-lysine N-methyltransferase 2E isoform X4

    9. XM_063285955.1 → XP_063142025.1  inactive histone-lysine N-methyltransferase 2E isoform X5

    RNA

    1. XR_010065633.1 RNA Sequence

    2. XR_010065634.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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