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    Zfp518a zinc finger protein 518A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 309478, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Zfp518aprovided by RGD
    Official Full Name
    zinc finger protein 518Aprovided by RGD
    Primary source
    RGD:1305314
    See related
    Ensembl:ENSRNOG00000036592 AllianceGenome:RGD:1305314
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Znf518; Znf518a; RGD1305314
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF518A (zinc finger protein 518A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 117.9), Lung (RPKM 81.0) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Zfp518a in Genome Data Viewer
    Location:
    1q54
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 1 NC_086019.1 (249668815..249694401)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 1 NC_051336.1 (239719305..239744978)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 1 NC_005100.4 (260152881..260178360)

    Chromosome 1 - NC_086019.1Genomic Context describing neighboring genes Neighboring gene cyclin J Neighboring gene U4 spliceosomal RNA Neighboring gene B-cell linker Neighboring gene uncharacterized LOC120100035 Neighboring gene DNA nucleotidylexotransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    2. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124846

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 518A
    Names
    zinc finger protein 518

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001030038.2 → NP_001025209.1  zinc finger protein 518A

      See identical proteins and their annotated locations for NP_001025209.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000001
      UniProtKB/Swiss-Prot
      Q499R0
      Related
      ENSRNOP00000051600.2, ENSRNOT00000054717.4
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086019.1 Reference GRCr8

      Range
      249668815..249694401
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006231397.5 → XP_006231459.1  zinc finger protein 518A isoform X1

      See identical proteins and their annotated locations for XP_006231459.1

      UniProtKB/Swiss-Prot
      Q499R0
      Related
      ENSRNOP00000095709.1
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_039080611.2 → XP_038936539.1  zinc finger protein 518A isoform X1

      UniProtKB/Swiss-Prot
      Q499R0
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_008760440.4 → XP_008758662.1  zinc finger protein 518A isoform X1

      See identical proteins and their annotated locations for XP_008758662.1

      UniProtKB/Swiss-Prot
      Q499R0
      Related
      ENSRNOP00000092189.1
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_039080620.2 → XP_038936548.1  zinc finger protein 518A isoform X1

      UniProtKB/Swiss-Prot
      Q499R0
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_006231398.5 → XP_006231460.1  zinc finger protein 518A isoform X1

      See identical proteins and their annotated locations for XP_006231460.1

      UniProtKB/Swiss-Prot
      Q499R0
      Related
      ENSRNOP00000080397.1
      Conserved Domains (1) summary
      sd00017
      Location:211 → 231
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q499R0.1 GenPept UniProtKB/Swiss-Prot:Q499R0

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