Mx2 MX dynamin like GTPase 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mx2provided by RGD
Official Full Name: MX dynamin like GTPase 2provided by RGD
Primary source: RGD:628821
See related: Ensembl:ENSRNOG00000001963 AllianceGenome:RGD:628821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Mx3
Summary: Predicted to enable GTP binding activity; GTPase activity; and microtubule binding activity. Involved in response to virus. Located in cytoplasm. Human ortholog(s) of this gene implicated in alopecia areata; avian influenza; liver disease; and prostate cancer. Orthologous to human MX1 (MX dynamin like GTPase 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 127.4), Lung (RPKM 94.9) and 8 other tissues See more
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Genomic context

Location:: 11q12

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	11	NC_086029.1 (50375101..50399373)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	11	NC_051346.1 (36905698..36936308)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	11	NC_005110.4 (38035306..38066185)

Chromosome 11 - NC_086029.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Six differentially expressed genes (Kcne1, Rcan1, Mx1, Mx2, Tmprss2, and RGD1559516) were identified in the renal cortex, and three genes (Rcan1, Mx2, and Tmprss2) were identified in the renal medulla.
Title: [Differentially expressed genes in the locus associated with relative kidney weight and resting blood pressure in hypertensive rats of the ISIAH strain].

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables GTP binding	IEA Inferred from Electronic Annotation more info
enables GTP binding	ISO Inferred from Sequence Orthology more info
enables GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
enables GTPase activity	IEA Inferred from Electronic Annotation more info
enables GTPase activity	ISO Inferred from Sequence Orthology more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cellular response to type I interferon	ISO Inferred from Sequence Orthology more info
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in defense response to virus	ISO Inferred from Sequence Orthology more info
involved_in endosomal transport	ISO Inferred from Sequence Orthology more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of intracellular transport of viral material	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of viral genome replication	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of nucleocytoplasmic transport	ISO Inferred from Sequence Orthology more info
involved_in response to interferon-alpha	ISO Inferred from Sequence Orthology more info
involved_in response to virus	IDA Inferred from Direct Assay more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in exocytic vesicle	ISO Inferred from Sequence Orthology more info
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
part_of nuclear pore	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interferon-induced GTP-binding protein Mx2

Names: interferon-induced GTP-binding protein Mx3; myxovirus (influenza virus) resistance 2; myxovirus (influenza virus) resistance 3; myxovirus resistance protein 2; myxovirus resistance protein 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_134350.2 → NP_599177.2 interferon-induced GTP-binding protein Mx2

See identical proteins and their annotated locations for NP_599177.2

Status: PROVISIONAL

Source sequence(s)

BC099808

UniProtKB/TrEMBL

A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3

Related

ENSRNOP00000075496.1, ENSRNOT00000087603.2

Conserved Domains (3) summary

cd08771
Location:66 → 338

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:258 → 544

Dynamin_M; Dynamin central region

pfam02212
Location:569 → 657

GED; Dynamin GTPase effector domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086029.1 Reference GRCr8

Range

50375101..50399373

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039088055.2 → XP_038943983.1 interferon-induced GTP-binding protein Mx2 isoform X1

UniProtKB/TrEMBL

A0A0G2KA85, A0A0G2KAR4, A6IQG6, Q499Q3

Conserved Domains (3) summary

cd08771
Location:66 → 338

DLP_1; Dynamin_like protein family includes dynamins and Mx proteins

pfam01031
Location:258 → 544

Dynamin_M; Dynamin central region

pfam02212
Location:569 → 657

GED; Dynamin GTPase effector domain
XM_063270316.1 → XP_063126386.1 interferon-induced GTP-binding protein Mx2 isoform X1

UniProtKB/TrEMBL

A0A0G2KAR4, A6IQG6, Q499Q3
XM_063270317.1 → XP_063126387.1 interferon-induced GTP-binding protein Mx2 isoform X1

UniProtKB/TrEMBL

A0A0G2KAR4, A6IQG6, Q499Q3
XM_063270318.1 → XP_063126388.1 interferon-induced GTP-binding protein Mx2 isoform X1

UniProtKB/TrEMBL

A0A0G2KAR4, A6IQG6, Q499Q3