Il5ra interleukin 5 receptor subunit alpha [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Il5raprovided by RGD
Official Full Name: interleukin 5 receptor subunit alphaprovided by RGD
Primary source: RGD:70938
See related: Ensembl:ENSRNOG00000005954 AllianceGenome:RGD:70938
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable cytokine binding activity and cytokine receptor activity. Predicted to be involved in cytokine-mediated signaling pathway. Predicted to act upstream of or within cellular response to organic substance; inflammatory response to antigenic stimulus; and regulation of interleukin-5 production. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in external side of plasma membrane. Human ortholog(s) of this gene implicated in asthma. Orthologous to human IL5RA (interleukin 5 receptor subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 10.8), Thymus (RPKM 3.5) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q41

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (141186749..141221348, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (139630652..139664593, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (138796165..138834164, complement)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data suggest that IL5/IL5Ra signaling activates JAK2 in neurons down-regulating cell apoptosis and down-regulating hyperphosphorylation of Tau [up-regulated in Alzheimer disease via amyloid-beta(25-35) peptide]. [IL5 = interleukin-5 ; IL5Ra = interleukin-5 receptor, alpha subunit; JAK2 = Janus kinase 2]
Title: IL-5 blocks apoptosis and tau hyperphosphorylation induced by Aβ(25-35) peptide in PC12 cells.

Submit: New GeneRIF Correction

General gene information

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Markers

D4Rat274 (e-PCR), detects polymorphism
- UniSTS:227817

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables cytokine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine receptor activity	TAS Traceable Author Statement more info	PubMed
enables interleukin-5 receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to organic substance	ISO Inferred from Sequence Orthology more info
involved_in cytokine-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in immunoglobulin mediated immune response	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within inflammatory response to antigenic stimulus	ISO Inferred from Sequence Orthology more info
involved_in interleukin-5-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of interleukin-5 production	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: interleukin-5 receptor subunit alpha

Names: interleukin 5 receptor, alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053645.1 → NP_446097.1 interleukin-5 receptor subunit alpha precursor

See identical proteins and their annotated locations for NP_446097.1

Status: PROVISIONAL

Source sequence(s)

AB056101

UniProtKB/TrEMBL

A6IBK1, Q920B8, Q99PS3

Conserved Domains (1) summary

pfam09240
Location:124 → 231

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

141186749..141221348 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236977.5 → XP_006237039.1 interleukin-5 receptor subunit alpha isoform X1

UniProtKB/TrEMBL

A6IBK1, G3V6S7

Related

ENSRNOP00000008403.2

Conserved Domains (1) summary

pfam09240
Location:158 → 265

IL6Ra-bind; Interleukin-6 receptor alpha chain, binding