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    Lasp1 LIM and SH3 protein 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 29278, updated on 13-Apr-2024

    Summary

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    Official Symbol
    Lasp1provided by RGD
    Official Full Name
    LIM and SH3 protein 1provided by RGD
    Primary source
    RGD:68408
    See related
    Ensembl:ENSRNOG00000004132 AllianceGenome:RGD:68408
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables ion transmembrane transporter activity. Involved in ion transport. Located in cortical actin cytoskeleton. Orthologous to human LASP1 (LIM and SH3 protein 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Kidney (RPKM 384.6), Lung (RPKM 305.7) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    10q31
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 10 NC_086028.1 (83290820..83331989)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 10 NC_051345.1 (82795177..82835659)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 10 NC_005109.4 (85744662..85785130)

    Chromosome 10 - NC_086028.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) 34 Neighboring gene transfer RNA cysteine (anticodon GCA) 35 Neighboring gene F-box protein 47 Neighboring gene U7 small nuclear RNA Neighboring gene plexin domain containing 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines. Phillips GR, et al. J Neurosci Res, 2004 Oct 1. PMID 15372503
    2. The LIM and SH3 domain-containing protein, lasp-1, may link the cAMP signaling pathway with dynamic membrane restructuring activities in ion transporting epithelia. Chew CS, et al. J Cell Sci, 2000 Jun. PMID 10806114
    3. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development. Pollitt SL, et al. Mol Biol Cell, 2020 Nov 15. PMID 32997597, Free PMC Article
    4. Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium. Nicholson L, et al. Reprod Fertil Dev, 2018 Oct. PMID 29739492
    5. Lasp-1 regulates podosome function. Stölting M, et al. PLoS One, 2012. PMID 22514729, Free PMC Article

    See all (16) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
      Title: Up-regulated microRNA-218-5p ameliorates the damage of dopaminergic neurons in rats with Parkinson's disease via suppression of LASP1.
    2. LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
      Title: LIM and SH3 protein 1 localizes to the leading edge of protruding lamellipodia and regulates axon development.
    3. Lasp-1 was increased in the uterus at the time of implantation compared with the time of fertilization.
      Title: Change in distribution of cytoskeleton-associated proteins, lasp-1 and palladin, during uterine receptivity in the rat endometrium.
    4. Data indicate that Lasp-1 is a novel component of podosomes and is involved in the regulation of podosomal function.
      Title: Lasp-1 regulates podosome function.
    5. binding sites necessary for Krp1-Lasp1 interaction in vitro and function in vivo
      Title: Novel beta-propeller of the BTB-Kelch protein Krp1 provides a binding site for Lasp-1 that is necessary for pseudopodial extension.
    6. Lasp-1 is strongly expressed by central nervous system neurons and is concentrated at synaptic sites.
      Title: Actin-binding proteins in a postsynaptic preparation: Lasp-1 is a component of central nervous system synapses and dendritic spines.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables actin filament binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables monoatomic ion transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in monoatomic ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cell cortex IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in focal adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in focal adhesion ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    LIM and SH3 domain protein 1
    Names
    LASP-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032613.3 → NP_116002.1  LIM and SH3 domain protein 1

      See identical proteins and their annotated locations for NP_116002.1

      Status: PROVISIONAL

      Source sequence(s)
      JAXUCZ010000010
      UniProtKB/Swiss-Prot
      Q499R9, Q99MZ8
      UniProtKB/TrEMBL
      A0A8I6G1X8, A6HIN2
      Related
      ENSRNOP00000005522.5, ENSRNOT00000005522.8
      Conserved Domains (3) summary
      smart00227
      Location:98 → 128
      NEBU; The Nebulin repeat is present also in Las1
      cd09447
      Location:5 → 57
      LIM_LASP; The LIM domain of LIM and SH3 Protein (LASP)
      cd11934
      Location:205 → 263
      SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086028.1 Reference GRCr8

      Range
      83290820..83331989
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063268798.1 → XP_063124868.1  LIM and SH3 domain protein 1 isoform X1

      UniProtKB/Swiss-Prot
      Q499R9, Q99MZ8
      UniProtKB/TrEMBL
      A6HIN2

    2. XM_006247288.5 → XP_006247350.1  LIM and SH3 domain protein 1 isoform X2

      UniProtKB/TrEMBL
      A0A8I6G1X8
      Conserved Domains (3) summary
      smart00227
      Location:62 → 92
      NEBU; The Nebulin repeat is present also in Las1
      cd11934
      Location:169 → 227
      SH3_Lasp1_C; C-terminal Src Homology 3 domain of LIM and SH3 domain protein 1
      cl02475
      Location:1 → 21
      LIM; LIM is a small protein-protein interaction domain, containing two zinc fingers

    3. XM_063268799.1 → XP_063124869.1  LIM and SH3 domain protein 1 isoform X3

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99MZ8.1 GenPept UniProtKB/Swiss-Prot:Q99MZ8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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