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    Mrpl52 mitochondrial ribosomal protein L52 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 361037, updated on 30-Mar-2024

    Summary

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    Official Symbol
    Mrpl52provided by RGD
    Official Full Name
    mitochondrial ribosomal protein L52provided by RGD
    Primary source
    RGD:1309297
    See related
    Ensembl:ENSRNOG00000039297 AllianceGenome:RGD:1309297
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be a structural constituent of ribosome. Predicted to be involved in translation. Predicted to be located in mitochondrion and nucleoplasm. Predicted to be part of mitochondrial large ribosomal subunit. Orthologous to human MRPL52 (mitochondrial ribosomal protein L52). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Adrenal (RPKM 224.4), Kidney (RPKM 192.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Mrpl52 in Genome Data Viewer
    Location:
    15p13
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (31852927..31856160)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (27882777..27886131)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33069479..33072777)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene OXA1L, mitochondrial inner membrane protein Neighboring gene solute carrier family 7 member 7 Neighboring gene matrix metallopeptidase 14 Neighboring gene uncharacterized LOC102550180

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Structures of the human mitochondrial ribosome in native states of assembly. Brown A, et al. Nat Struct Mol Biol, 2017 Oct. PMID 28892042, Free PMC Article
    2. Structure of the large ribosomal subunit from human mitochondria. Brown A, et al. Science, 2014 Nov 7. PMID 25278503, Free PMC Article
    3. A mitochondrial protein compendium elucidates complex I disease biology. Pagliarini DJ, et al. Cell, 2008 Jul 11. PMID 18614015, Free PMC Article
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of mitochondrial large ribosomal subunit IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mitochondrial large ribosomal subunit ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrion ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    large ribosomal subunit protein mL52
    Names
    39S ribosomal protein L52, mitochondrial

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001108375.2 → NP_001101845.2  large ribosomal subunit protein mL52

      See identical proteins and their annotated locations for NP_001101845.2

      Status: VALIDATED

      Source sequence(s)
      BC166922, JAXUCZ010000015
      UniProtKB/TrEMBL
      B2RYV8
      Related
      ENSRNOT00000060193.5

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      31852927..31856160
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017599738.3 → XP_017455227.1  large ribosomal subunit protein mL52 isoform X4

    2. XM_039093484.2 → XP_038949412.1  large ribosomal subunit protein mL52 isoform X3

      Conserved Domains (2) summary
      pfam18699
      Location:23 → 51
      MRPL52; Mitoribosomal protein mL52
      cl21454
      Location:3 → 77
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    3. XM_006251976.5 → XP_006252038.1  large ribosomal subunit protein mL52 isoform X1

      Conserved Domains (1) summary
      pfam18699
      Location:23 → 111
      MRPL52; Mitoribosomal protein mL52

    4. XM_017599737.3 → XP_017455226.1  large ribosomal subunit protein mL52 isoform X2

      UniProtKB/TrEMBL
      A6KGT5
    Nucleotide Protein Strain
    Heading Accession and Version

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