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    Trip12 thyroid hormone receptor interactor 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 316575, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Trip12provided by RGD
    Official Full Name
    thyroid hormone receptor interactor 12provided by RGD
    Primary source
    RGD:1306607
    See related
    Ensembl:ENSRNOG00000016963 AllianceGenome:RGD:1306607
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Gtl6; TRIP-12
    Summary
    Predicted to enable thyroid hormone receptor binding activity and ubiquitin protein ligase activity. Predicted to be involved in several processes, including cellular protein metabolic process; negative regulation of nitrogen compound metabolic process; and regulation of embryonic development. Predicted to be located in nucleoplasm. Predicted to be active in nuclear speck. Human ortholog(s) of this gene implicated in Clark-Baraitser syndrome. Orthologous to human TRIP12 (thyroid hormone receptor interactor 12). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Testes (RPKM 540.0), Kidney (RPKM 380.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    9q35
    Exon count:
    46
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (93364791..93491015, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (85916691..86043312, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (92305059..92435388, complement)

    Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene delta/notch-like EGF repeat containing Neighboring gene uncharacterized LOC120094725 Neighboring gene uncharacterized LOC134480598 Neighboring gene F-box protein 36 Neighboring gene uncharacterized LOC102550706 Neighboring gene uncharacterized LOC120094727 Neighboring gene solute carrier family 16, member 14

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses. Chen D, et al. Nature, 2010 Mar 25. PMID 20208519, Free PMC Article
    2. The HECT domain of TRIP12 ubiquitinates substrates of the ubiquitin fusion degradation pathway. Park Y, et al. J Biol Chem, 2009 Jan 16. PMID 19028681
    3. The E3 ubiquitin ligase activity of Trip12 is essential for mouse embryogenesis. Kajiro M, et al. PLoS One, 2011. PMID 22028794, Free PMC Article
    4. TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. Park Y, et al. Biochem Biophys Res Commun, 2008 Sep 19. PMID 18627766
    5. An Adversarial DNA N(6)-Methyladenine-Sensor Network Preserves Polycomb Silencing. Kweon SM, et al. Mol Cell, 2019 Jun 20. PMID 30982744, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC124674, MGC125132

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nuclear thyroid hormone receptor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA repair-dependent chromatin remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in heterochromatin boundary formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin boundary formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein polyubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein polyubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of embryonic development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of embryonic development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in ubiquitin-dependent protein catabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nuclear speck IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase TRIP12
    Names
    HECT-type E3 ubiquitin transferase TRIP12
    TR-interacting protein 12
    gene trap locus 6
    probable E3 ubiquitin-protein ligase TRIP12
    thyroid receptor-interacting protein 12
    NP_001026829.2
    XP_006245441.1
    XP_006245442.1
    XP_008765474.1
    XP_017451976.1
    XP_017451977.1
    XP_038939631.1
    XP_038939637.1
    XP_038939639.1
    XP_038939640.1
    XP_063123308.1
    XP_063123309.1
    XP_063123310.1
    XP_063123311.1
    XP_063123313.1
    XP_063123314.1
    XP_063123315.1
    XP_063123316.1
    XP_063123317.1
    XP_063123318.1
    XP_063123319.1
    XP_063123320.1
    XP_063123321.1
    XP_063123323.1
    XP_063123324.1
    XP_063123325.1
    XP_063123326.1
    XP_063123327.1
    XP_063123328.1
    XP_063123329.1
    XP_063123331.1
    XP_063123332.1
    XP_063123333.1
    XP_063123334.1
    XP_063123335.1
    XP_063123336.1
    XP_063123337.1
    XP_063123338.1
    XP_063123339.1
    XP_063123340.1
    XP_063123341.1
    XP_063123342.1
    XP_063123343.1
    XP_063123344.1
    XP_063123345.1
    XP_063123346.1
    XP_063123347.1
    XP_063123348.1
    XP_063123349.1
    XP_063123350.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001031659.4 → NP_001026829.2  E3 ubiquitin-protein ligase TRIP12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000009
      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0
      UniProtKB/TrEMBL
      A6JWC9
      Related
      ENSRNOP00000076130.2, ENSRNOT00000093245.2
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1623 → 2023
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:767 → 831
      WWE; WWE domain
      pfam03546
      Location:99 → 377
      Treacle; Treacher Collins syndrome protein Treacle

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086027.1 Reference GRCr8

      Range
      93364791..93491015 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063267250.1 → XP_063123320.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHN4

    2. XM_063267247.1 → XP_063123317.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    3. XM_063267240.1 → XP_063123310.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    4. XM_063267279.1 → XP_063123349.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

    5. XM_063267267.1 → XP_063123337.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4

    6. XM_063267280.1 → XP_063123350.1  E3 ubiquitin-protein ligase TRIP12 isoform X25

    7. XM_063267278.1 → XP_063123348.1  E3 ubiquitin-protein ligase TRIP12 isoform X23

    8. XM_063267276.1 → XP_063123346.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

    9. XM_039083712.2 → XP_038939640.1  E3 ubiquitin-protein ligase TRIP12 isoform X26

      UniProtKB/TrEMBL
      A6JWC9
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1591 → 1991
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 803
      WWE; WWE domain
      pfam15229
      Location:11 → 150
      POM121; POM121 family

    10. XM_017596488.3 → XP_017451977.1  E3 ubiquitin-protein ligase TRIP12 isoform X24

      UniProtKB/TrEMBL
      A6JWC9

    11. XM_063267274.1 → XP_063123344.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

    12. XM_039083711.2 → XP_038939639.1  E3 ubiquitin-protein ligase TRIP12 isoform X20

      UniProtKB/TrEMBL
      A6JWC9
      Conserved Domains (4) summary
      COG5064
      Location:447 → 672
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1618 → 2018
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:769 → 830
      WWE; WWE domain
      pfam15229
      Location:11 → 150
      POM121; POM121 family

    13. XM_063267266.1 → XP_063123336.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4

    14. XM_063267273.1 → XP_063123343.1  E3 ubiquitin-protein ligase TRIP12 isoform X19

    15. XM_063267269.1 → XP_063123339.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

    16. XM_063267262.1 → XP_063123332.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    17. XM_039083709.2 → XP_038939637.1  E3 ubiquitin-protein ligase TRIP12 isoform X14

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      COG5064
      Location:460 → 685
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1631 → 2031
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:782 → 843
      WWE; WWE domain

    18. XM_063267258.1 → XP_063123328.1  E3 ubiquitin-protein ligase TRIP12 isoform X11

    19. XM_063267257.1 → XP_063123327.1  E3 ubiquitin-protein ligase TRIP12 isoform X9

    20. XM_063267261.1 → XP_063123331.1  E3 ubiquitin-protein ligase TRIP12 isoform X13

    21. XM_063267259.1 → XP_063123329.1  E3 ubiquitin-protein ligase TRIP12 isoform X12

    22. XM_017596487.3 → XP_017451976.1  E3 ubiquitin-protein ligase TRIP12 isoform X10

      UniProtKB/TrEMBL
      A0A0G2JU73

    23. XM_063267256.1 → XP_063123326.1  E3 ubiquitin-protein ligase TRIP12 isoform X8

    24. XM_039083703.2 → XP_038939631.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      COG5064
      Location:489 → 714
      SRP1; Karyopherin (importin) alpha [Intracellular trafficking and secretion]
      cd00078
      Location:1660 → 2060
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:811 → 872
      WWE; WWE domain

    25. XM_063267253.1 → XP_063123323.1  E3 ubiquitin-protein ligase TRIP12 isoform X5

    26. XM_006245379.5 → XP_006245441.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A0G2JU73, A0A8I6AHN4
      Related
      ENSRNOP00000092462.1
      Conserved Domains (3) summary
      smart00119
      Location:1683 → 2061
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1665 → 2065
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 873
      WWE; WWE domain

    27. XM_063267243.1 → XP_063123313.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    28. XM_006245380.5 → XP_006245442.1  E3 ubiquitin-protein ligase TRIP12 isoform X6

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      smart00119
      Location:1679 → 2057
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1661 → 2061
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain

    29. XM_063267251.1 → XP_063123321.1  E3 ubiquitin-protein ligase TRIP12 isoform X4

    30. XM_008767252.4 → XP_008765474.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

      See identical proteins and their annotated locations for XP_008765474.1

      UniProtKB/TrEMBL
      A0A0G2JU73
      Conserved Domains (3) summary
      smart00119
      Location:1687 → 2065
      HECTc; Domain Homologous to E6-AP Carboxyl Terminus with
      cd00078
      Location:1669 → 2069
      HECTc; HECT domain; C-terminal catalytic domain of a subclass of Ubiquitin-protein ligase (E3). It binds specific ubiquitin-conjugating enzymes (E2), accepts ubiquitin from E2, transfers ubiquitin to substrate lysine side chains, and transfers additional ...
      pfam02825
      Location:808 → 874
      WWE; WWE domain

    31. XM_063267268.1 → XP_063123338.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4

    32. XM_063267241.1 → XP_063123311.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    33. XM_063267272.1 → XP_063123342.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0

    34. XM_063267264.1 → XP_063123334.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    35. XM_063267254.1 → XP_063123324.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    36. XM_063267249.1 → XP_063123319.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHN4

    37. XM_063267246.1 → XP_063123316.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    38. XM_063267275.1 → XP_063123345.1  E3 ubiquitin-protein ligase TRIP12 isoform X21

    39. XM_063267277.1 → XP_063123347.1  E3 ubiquitin-protein ligase TRIP12 isoform X22

    40. XM_063267271.1 → XP_063123341.1  E3 ubiquitin-protein ligase TRIP12 isoform X18

      UniProtKB/Swiss-Prot
      F1LP64, F1LP79, Q497C1, Q5I0I0

    41. XM_063267265.1 → XP_063123335.1  E3 ubiquitin-protein ligase TRIP12 isoform X16

      UniProtKB/TrEMBL
      A0A8L2RBG4

    42. XM_063267270.1 → XP_063123340.1  E3 ubiquitin-protein ligase TRIP12 isoform X17

    43. XM_063267263.1 → XP_063123333.1  E3 ubiquitin-protein ligase TRIP12 isoform X15

    44. XM_063267255.1 → XP_063123325.1  E3 ubiquitin-protein ligase TRIP12 isoform X7

    45. XM_063267248.1 → XP_063123318.1  E3 ubiquitin-protein ligase TRIP12 isoform X3

      UniProtKB/TrEMBL
      A0A8I6AHN4

    46. XM_063267244.1 → XP_063123314.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    47. XM_063267238.1 → XP_063123308.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    48. XM_063267245.1 → XP_063123315.1  E3 ubiquitin-protein ligase TRIP12 isoform X2

    49. XM_063267239.1 → XP_063123309.1  E3 ubiquitin-protein ligase TRIP12 isoform X1

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F1LP64.1 GenPept UniProtKB/Swiss-Prot:F1LP64

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