Cluap1 clusterin associated protein 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cluap1provided by RGD
Official Full Name: clusterin associated protein 1provided by RGD
Primary source: RGD:1359189
See related: Ensembl:ENSRNOG00000007117 AllianceGenome:RGD:1359189
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to be involved in cilium assembly. Predicted to act upstream of or within several processes, including axoneme assembly; embryonic morphogenesis; and left/right pattern formation. Predicted to be located in ciliary base; ciliary tip; and nucleoplasm. Predicted to be part of intraciliary transport particle A and intraciliary transport particle B. Predicted to be active in centrosome and cilium. Orthologous to human CLUAP1 (clusterin associated protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 179.7), Brain (RPKM 127.6) and 9 other tissues See more
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Genomic context

Location:: 10q12

Exon count:: 22

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (12094346..12159440, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (11587963..11619711, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (11847058..11878792, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Markers

BF406341 (e-PCR)
- UniSTS:248344

RH132312 (e-PCR)
- UniSTS:215595

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables histone H4 acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide alpha-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in axoneme assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axoneme assembly	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell projection organization	IEA Inferred from Electronic Annotation more info
involved_in chromosome segregation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cilium assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info
involved_in floor plate formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within floor plate formation	ISO Inferred from Sequence Orthology more info
involved_in heart looping	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within heart looping	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within left/right pattern formation	ISO Inferred from Sequence Orthology more info
involved_in neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	ISO Inferred from Sequence Orthology more info
involved_in nucleosome assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within smoothened signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
is_active_in cellular_component	ND No biological Data available more info
is_active_in centrosome	IBA Inferred from Biological aspect of Ancestor more info
located_in centrosome	IEA Inferred from Electronic Annotation more info
located_in centrosome	ISO Inferred from Sequence Orthology more info
located_in ciliary base	IEA Inferred from Electronic Annotation more info
located_in ciliary base	ISO Inferred from Sequence Orthology more info
located_in ciliary tip	IEA Inferred from Electronic Annotation more info
located_in ciliary tip	ISO Inferred from Sequence Orthology more info
is_active_in cilium	IBA Inferred from Biological aspect of Ancestor more info
located_in cilium	ISO Inferred from Sequence Orthology more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
part_of intraciliary transport particle A	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle A	ISO Inferred from Sequence Orthology more info
part_of intraciliary transport particle B	IBA Inferred from Biological aspect of Ancestor more info
part_of intraciliary transport particle B	IEA Inferred from Electronic Annotation more info
part_of intraciliary transport particle B	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: clusterin-associated protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001014225.1 → NP_001014247.1 clusterin-associated protein 1 isoform 4

See identical proteins and their annotated locations for NP_001014247.1

Status: PROVISIONAL

Source sequence(s)

BC079022

UniProtKB/Swiss-Prot

Q6AYJ5

Related

ENSRNOP00000062395.1, ENSRNOT00000064964.3

Conserved Domains (1) summary

pfam10234
Location:8 → 267

Cluap1; Clusterin-associated protein-1
NM_001399473.1 → NP_001386402.1 clusterin-associated protein 1 isoform 1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A0G2K129

Related

ENSRNOP00000071678.1, ENSRNOT00000078577.2

Conserved Domains (1) summary

pfam10234
Location:14 → 283

Cluap1; Clusterin-associated protein-1
NM_001399474.1 → NP_001386403.1 clusterin-associated protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A0A8I6A8I1

Related

ENSRNOP00000088045.1, ENSRNOT00000109816.1

Conserved Domains (1) summary

pfam10234
Location:14 → 251

Cluap1; Clusterin-associated protein-1
NM_001399475.1 → NP_001386404.1 clusterin-associated protein 1 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/TrEMBL

A6K4U4

Conserved Domains (1) summary

pfam10234
Location:1 → 211

Cluap1; Clusterin-associated protein-1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

12094346..12159440 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063269485.1 → XP_063125555.1 clusterin-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6AYJ5
XM_063269483.1 → XP_063125553.1 clusterin-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6AYJ5
XM_008767517.4 → XP_008765739.1 clusterin-associated protein 1 isoform X2

See identical proteins and their annotated locations for XP_008765739.1

Conserved Domains (2) summary

pfam10234
Location:1 → 171

Cluap1; Clusterin-associated protein-1

cl15781
Location:156 → 237

K_trans; K+ potassium transporter
XM_063269484.1 → XP_063125554.1 clusterin-associated protein 1 isoform X1

UniProtKB/Swiss-Prot

Q6AYJ5
XM_063269491.1 → XP_063125561.1 clusterin-associated protein 1 isoform X5

UniProtKB/Swiss-Prot

Q3MHC1, Q7TMZ6
XM_063269486.1 → XP_063125556.1 clusterin-associated protein 1 isoform X3
XM_063269489.1 → XP_063125559.1 clusterin-associated protein 1 isoform X5

UniProtKB/Swiss-Prot

Q3MHC1, Q7TMZ6
XM_063269488.1 → XP_063125558.1 clusterin-associated protein 1 isoform X4
XM_063269487.1 → XP_063125557.1 clusterin-associated protein 1 isoform X3