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    Klhl9 kelch-like family member 9 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 313348, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Klhl9provided by RGD
    Official Full Name
    kelch-like family member 9provided by RGD
    Primary source
    RGD:1304814
    See related
    AllianceGenome:RGD:1304814
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    RGD1304814
    Summary
    Predicted to enable cullin family protein binding activity. Predicted to contribute to ubiquitin-protein transferase activity. Predicted to be involved in protein ubiquitination and regulation of cytokinesis. Predicted to be part of Cul3-RING ubiquitin ligase complex. Predicted to be active in midbody. Orthologous to human KLHL9 (kelch like family member 9). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl9 in Genome Data Viewer
    Location:
    5q32
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (108449492..108453676, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (103333747..103337931, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (107323258..107327442)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene interferon, alpha 4 like 2 Neighboring gene interferon alpha-1-like Neighboring gene ribosomal protein L27a, pseudogene 12 Neighboring gene ribosomal protein S24, pseudogene 10 Neighboring gene uncharacterized LOC134479080

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. A Cul3-based E3 ligase removes Aurora B from mitotic chromosomes, regulating mitotic progression and completion of cytokinesis in human cells. Sumara I, et al. Dev Cell, 2007 Jun. PMID 17543862
    2. The Cul3-KLHL21 E3 ubiquitin ligase targets aurora B to midzone microtubules in anaphase and is required for cytokinesis. Maerki S, et al. J Cell Biol, 2009 Dec 14. PMID 19995937, Free PMC Article
    3. Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases. Furukawa M, et al. Nat Cell Biol, 2003 Nov. PMID 14528312
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cullin family protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables cullin family protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to ubiquitin-protein transferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    contributes_to ubiquitin-protein transferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 9
    Names
    kelch-like 9

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001107944.1 → NP_001101414.1  kelch-like protein 9

      See identical proteins and their annotated locations for NP_001101414.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473998
      UniProtKB/TrEMBL
      A0A8I5ZU85, B5DEL5
      Conserved Domains (3) summary
      PHA03098
      Location:50 → 593
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:337 → 385
      Kelch; KELCH repeat [structural motif]
      cd18239
      Location:27 → 154
      BTB_POZ_KLHL9_13; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL9 and KLHL13

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      108449492..108453676 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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