Esyt2 extended synaptotagmin 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Esyt2provided by RGD
Full Name: extended synaptotagmin 2provided by RGD
Primary source: RGD:1565705
See related: Ensembl:ENSRNOG00000032391 AllianceGenome:RGD:1565705
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: RGD1565705
Summary: Predicted to enable calcium ion binding activity; identical protein binding activity; and phospholipid binding activity. Predicted to be involved in endoplasmic reticulum-plasma membrane tethering and lipid transport. Predicted to be located in endoplasmic reticulum-plasma membrane contact site. Predicted to be integral component of plasma membrane. Predicted to be extrinsic component of cytoplasmic side of plasma membrane and intrinsic component of endoplasmic reticulum membrane. Orthologous to human ESYT2 (extended synaptotagmin 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 388.5), Lung (RPKM 273.1) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q33

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (143359870..143455600)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (137219653..137312590)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (144156021..144248374)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

visual signals derived from the rat ChR2-expressing retinal ganglion cells under the control of a mouse Thy-1.2 promotor are reinterpreted by the brain to form behavior-related vision
Title: Visual properties of transgenic rats harboring the channelrhodopsin-2 gene regulated by the thy-1.2 promoter.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI229438 (e-PCR)
- UniSTS:261770

RH134571 (e-PCR)
- UniSTS:217851

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables calcium ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables calcium-dependent phospholipid binding	IBA Inferred from Biological aspect of Ancestor more info
enables calcium-dependent phospholipid binding	ISO Inferred from Sequence Orthology more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylcholine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylcholine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylethanolamine binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylethanolamine binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in endoplasmic reticulum-plasma membrane tethering	IEA Inferred from Electronic Annotation more info
involved_in lipid transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasmic side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-plasma membrane contact site	ISO Inferred from Sequence Orthology more info
located_in organelle membrane contact site	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: extended synaptotagmin-2

Names: extended synaptotagmin protein 2; extended synaptotagmin-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001271169.1 → NP_001258098.1 extended synaptotagmin-2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000006

UniProtKB/TrEMBL

A6KDL4, D3ZJ32

Related

ENSRNOP00000006582.7, ENSRNOT00000006582.8

Conserved Domains (4) summary

cd04030
Location:710 → 835

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 566

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086024.1 Reference GRCr8

Range

143359870..143455600

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063261796.1 → XP_063117866.1 extended synaptotagmin-2 isoform X1
XM_039112112.2 → XP_038968040.1 extended synaptotagmin-2 isoform X4

Conserved Domains (4) summary

cd04030
Location:765 → 890

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 621

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_063261797.1 → XP_063117867.1 extended synaptotagmin-2 isoform X2
XM_039112113.2 → XP_038968041.1 extended synaptotagmin-2 isoform X6

Conserved Domains (4) summary

cd04030
Location:744 → 869

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 600

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_063261798.1 → XP_063117868.1 extended synaptotagmin-2 isoform X3
XM_039112114.2 → XP_038968042.1 extended synaptotagmin-2 isoform X7

UniProtKB/TrEMBL

A0A8I6A660

Related

ENSRNOP00000086527.1

Conserved Domains (4) summary

cd04030
Location:731 → 856

C2C_KIAA1228; C2 domain third repeat present in uncharacterized human KIAA1228-like proteins

cd04050
Location:461 → 587

C2B_Synaptotagmin-like; C2 domain second repeat present in Synaptotagmin-like proteins

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_063261799.1 → XP_063117869.1 extended synaptotagmin-2 isoform X5
XM_039112119.2 → XP_038968047.1 extended synaptotagmin-2 isoform X10

Conserved Domains (2) summary

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_039112120.2 → XP_038968048.1 extended synaptotagmin-2 isoform X11

Conserved Domains (2) summary

cd08391
Location:309 → 429

C2A_C2C_Synaptotagmin_like; C2 domain first and third repeat in Synaptotagmin-like proteins

pfam17047
Location:115 → 294

SMP_LBD; Synaptotagmin-like mitochondrial-lipid-binding domain
XM_063261800.1 → XP_063117870.1 extended synaptotagmin-2 isoform X8
XM_063261801.1 → XP_063117871.1 extended synaptotagmin-2 isoform X9