Mthfs methenyltetrahydrofolate synthetase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mthfsprovided by RGD
Official Full Name: methenyltetrahydrofolate synthetaseprovided by RGD
Primary source: RGD:1306876
See related: Ensembl:ENSRNOG00000013229 AllianceGenome:RGD:1306876
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity; ATP binding activity; and folic acid binding activity. Predicted to be involved in folic acid-containing compound metabolic process and glutamate metabolic process. Predicted to be located in cytosol and mitochondrial matrix. Predicted to be active in mitochondrion. Orthologous to several human genes including ST20-MTHFS (ST20-MTHFS readthrough). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 58.5), Liver (RPKM 57.6) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (98609410..98681901)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (89729498..89801998)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (96564877..96614386)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AW531027 (e-PCR)
- UniSTS:245064

AI119695 (e-PCR)
- UniSTS:163466

Mthfs (e-PCR), detects polymorphism
- UniSTS:526049

RH127353 (e-PCR)
- UniSTS:210663

RH140837 (e-PCR)
- UniSTS:210663

RH133023 (e-PCR)
- UniSTS:216306

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 5-formyltetrahydrofolate cyclo-ligase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 5-formyltetrahydrofolate cyclo-ligase activity	ISO Inferred from Sequence Orthology more info
enables ATP binding	ISO Inferred from Sequence Orthology more info
enables folic acid binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in folic acid catabolic process	ISO Inferred from Sequence Orthology more info
involved_in folic acid-containing compound biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glutamate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate interconversion	IBA Inferred from Biological aspect of Ancestor more info
involved_in tetrahydrofolate interconversion	ISO Inferred from Sequence Orthology more info
involved_in tetrahydrofolate metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in mitochondrial matrix	ISO Inferred from Sequence Orthology more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: 5-formyltetrahydrofolate cyclo-ligase

Names: 5, 10-methenyltetrahydrofolate synthetase; 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase)

NP_001009349.1

EC 6.3.3.2

XP_038937095.1

EC 6.3.3.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001009349.1 → NP_001009349.1 5-formyltetrahydrofolate cyclo-ligase

See identical proteins and their annotated locations for NP_001009349.1

Status: PROVISIONAL

Source sequence(s)

BC087144

UniProtKB/TrEMBL

A6I201, F7FDD4, Q5M9F6

Related

ENSRNOP00000017879.4, ENSRNOT00000017879.7

Conserved Domains (1) summary

pfam01812
Location:10 → 198

5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086026.1 Reference GRCr8

Range

98609410..98681901

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039081167.2 → XP_038937095.1 5-formyltetrahydrofolate cyclo-ligase isoform X1

Conserved Domains (1) summary

cl00360
Location:10 → 128

5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family