Acer3 alkaline ceramidase 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Acer3provided by RGD
Official Full Name: alkaline ceramidase 3provided by RGD
Primary source: RGD:1561254
See related: Ensembl:ENSRNOG00000036866 AllianceGenome:RGD:1561254
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Phca; RGD1561254
Summary: Predicted to enable N-acylsphingosine amidohydrolase activity and metal ion binding activity. Predicted to be involved in several processes, including inflammatory response; myelination; and sphingolipid metabolic process. Predicted to be integral component of Golgi membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human ACER3 (alkaline ceramidase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 172.5), Lung (RPKM 139.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q32

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (161915397..162017802, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (152504180..152606596, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (163160987..163263621, complement)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AU048681 (e-PCR)
- UniSTS:145131

BF389646 (e-PCR)
- UniSTS:245502

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables N-acylsphingosine amidohydrolase activity	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables ceramidase activity	IEA Inferred from Electronic Annotation more info
enables dihydroceramidase activity	ISO Inferred from Sequence Orthology more info
enables phytoceramidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables phytoceramidase activity	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in ceramide catabolic process	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in myelination	ISO Inferred from Sequence Orthology more info
involved_in phytosphingosine biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phytosphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in regulation of programmed cell death	ISO Inferred from Sequence Orthology more info
involved_in sphingosine biosynthetic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Golgi membrane	ISO Inferred from Sequence Orthology more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: alkaline ceramidase 3

Names: phytoceramidase, alkaline

NP_001387992.1

EC 3.5.1.23

XP_038957015.1

EC 3.5.1.23

XP_063127309.1

EC 3.5.1.23

XP_063127312.1

EC 3.5.1.23

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001401063.1 → NP_001387992.1 alkaline ceramidase 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I6D2

Related

ENSRNOP00000019987.6, ENSRNOT00000019987.8

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

161915397..162017802 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039101087.2 → XP_038957015.1 alkaline ceramidase 3 isoform X1

UniProtKB/TrEMBL

A0A8I6ADP7, F1M6P3

Related

ENSRNOP00000091431.1

Conserved Domains (1) summary

pfam05875
Location:9 → 287

Ceramidase
XM_063271239.1 → XP_063127309.1 alkaline ceramidase 3 isoform X2

UniProtKB/TrEMBL

A6I6D3
XM_063271242.1 → XP_063127312.1 alkaline ceramidase 3 isoform X3