Pyy peptide YY [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pyyprovided by RGD
Official Full Name: peptide YYprovided by RGD
Primary source: RGD:1593289
See related: Ensembl:ENSRNOG00000020877 AllianceGenome:RGD:1593289
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Yy; GHYY; RATGHYY; peptide-YY
Summary: Predicted to enable neuropeptide Y receptor binding activity and neuropeptide hormone activity. Involved in negative regulation of response to food. Located in extracellular space. Orthologous to several human genes including PYY (peptide YY). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Thymus (RPKM 2.2), Liver (RPKM 1.3) and 5 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q32.1

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (87561347..87562470, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (87061155..87062278, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (90047989..90049155, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.
Title: RYGB surgery has modest effects on intestinal morphology and gut hormone populations in the bypassed biliopancreatic limb but causes reciprocal changes in GLP-2 and PYY in the alimentary limb.
The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats.
Title: The role of calcium sensing receptors in GLP-1 and PYY secretion after acute intraduodenal administration of L-Tryptophan in rats.
Peptide YY mediates the satiety effects of diets enriched with whey protein fractions in male rats
Title: Peptide YY mediates the satiety effects of diets enriched with whey protein fractions in male rats.
Additional analysis of the findings demonstrated significant interactions of ovarian cycle stage and fed/fasted status with age on GLP-1, but not PYY plasma concentrations
Title: Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats.
These findings indicate that the mechanism underlying type 2 diabetes remission may be mediated by PYY.
Title: PYY-Dependent Restoration of Impaired Insulin and Glucagon Secretion in Type 2 Diabetes following Roux-En-Y Gastric Bypass Surgery.
Serum PYY levels were nonsignificantly decreased in rats with human neuroblastoma and hepatoblastoma transplants.
Title: Tumor-associated energy homeostasis: hepatoblastoma and neuroblastoma affect glucose and lipid metabolism as well as ghrelin, GLP-1, and PYY in nude rats.
The early effect of biliopancreatic diversion on resuming insulin resistance in rats may be associated with rapid modification of neurohormonal mechanisms involving PYY, apelin and visfatin, rather than with caloric restriction as proposed recently.
Title: Early-effect of bariatric surgery (Scopinaro method) on intestinal hormones and adipokines in insulin resistant Wistar rat.
gut PYY(3-36) action at Y2 receptors peripheral to the blood brain barrier plays an essential role in mediating satiety
Title: Role of peptide YY(3-36) in the satiety produced by gastric delivery of macronutrients in rats.
RACK1 modulates the ability of preglomerular vascular smooth muscle cells to respond to the proliferative actions of PYY.
Title: Role of RACK1 in the differential proliferative effects of neuropeptide Y(1-36) and peptide YY(1-36) in SHR vs. WKY preglomerular vascular smooth muscle cells.
Exercise in hypoxia suppressed hunger and increased PYY but did not influence ad libitum energy intake.
Title: Influence of rest and exercise at a simulated altitude of 4,000 m on appetite, energy intake, and plasma concentrations of acylated ghrelin and peptide YY.

Submit: New GeneRIF Correction See all GeneRIFs (19)

General gene information

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Markers

RH130253 (e-PCR)
- UniSTS:213540

Pyy (e-PCR), detects polymorphism
- UniSTS:516150

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables G protein-coupled receptor binding	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor binding	ISO Inferred from Sequence Orthology more info
enables hormone activity	IEA Inferred from Electronic Annotation more info
enables neuropeptide Y receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide Y receptor binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables neuropeptide hormone activity	ISO Inferred from Sequence Orthology more info
enables neuropeptide hormone activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
involved_in feeding behavior	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of response to food	IDA Inferred from Direct Assay more info	PubMed
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in extracellular space	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: peptide YY

Names: peptide tyrosine tyrosine; peptide tyrosine-tyrosine (YY)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034080.1 → NP_001029252.1 peptide YY precursor

See identical proteins and their annotated locations for NP_001029252.1

Status: VALIDATED

Source sequence(s)

AA998735, BF551062

UniProtKB/Swiss-Prot

P10631, Q3C1E8

UniProtKB/TrEMBL

A6HJG5, F1LSR6

Related

ENSRNOP00000028323.4, ENSRNOT00000028323.7

Conserved Domains (1) summary

cd00126
Location:29 → 64

PAH; Pancreatic Hormone domain, a regulator of pancreatic and gastrointestinal functions; neuropeptide Y (NPY)b, peptide YY (PYY), and pancreatic polypetide (PP) are closely related; propeptide is enzymatically cleaved to yield the mature active peptide with ...