Mtap methylthioadenosine phosphorylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Mtapprovided by RGD
Official Full Name: methylthioadenosine phosphorylaseprovided by RGD
Primary source: RGD:1310114
See related: Ensembl:ENSRNOG00000006615 AllianceGenome:RGD:1310114
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Cc1-6
Summary: Enables S-methyl-5-thioadenosine phosphorylase activity. Involved in response to testosterone. Predicted to be located in nucleoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in biliary tract benign neoplasm and diaphyseal medullary stenosis with malignant fibrous histiocytoma. Orthologous to human MTAP (methylthioadenosine phosphorylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Lung (RPKM 82.4), Adrenal (RPKM 74.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q32

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (108990270..109036494)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (103874460..103920684)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (107711077..107777530)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These protein profiles, and their interacting protein network, may facilitate the elucidation of the molecular mechanisms underlying the antiinflammatory effects of CC16.
Title: Label-free LC-MS/MS shotgun proteomics to investigate the anti-inflammatory effect of rCC16.

Submit: New GeneRIF Correction

General gene information

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Markers

BE119243 (e-PCR)
- UniSTS:249135

BI278369 (e-PCR)
- UniSTS:244347

RH140125 (e-PCR)
- UniSTS:222204

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables S-methyl-5-thioadenosine phosphorylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables S-methyl-5-thioadenosine phosphorylase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in L-methionine salvage from methylthioadenosine	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-methionine salvage from methylthioadenosine	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within methylation	ISO Inferred from Sequence Orthology more info
NOT involved_in nicotinamide riboside catabolic process	ISO Inferred from Sequence Orthology more info
involved_in purine ribonucleoside salvage	IEA Inferred from Electronic Annotation more info
involved_in response to testosterone	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: S-methyl-5'-thioadenosine phosphorylase

Names: 5'-methylthioadenosine phosphorylase

NP_001380978.1

EC 2.4.2.28

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001394049.1 → NP_001380978.1 S-methyl-5'-thioadenosine phosphorylase

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

UniProtKB/TrEMBL

A0A0G2K583, A6JRF0

Related

ENSRNOP00000073330.1, ENSRNOT00000090739.2

Conserved Domains (1) summary

cd09010
Location:12 → 255

MTAP_SsMTAPII_like_MTIP; 5'-deoxy-5'-methylthioadenosine phosphorylases (MTAP) similar to Sulfolobus solfataricus MTAPII and Pseudomonas aeruginosa PAO1 5'-methylthioinosine phosphorylase (MTIP)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

108990270..109036494

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_001047867.1: Suppressed sequence

Description

NM_001047867.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.