Abhd17a abhydrolase domain containing 17A, depalmitoylase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Abhd17aprovided by RGD
Official Full Name: abhydrolase domain containing 17A, depalmitoylaseprovided by RGD
Primary source: RGD:1359682
See related: Ensembl:ENSRNOG00000018212 AllianceGenome:RGD:1359682
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Fam108a; upf0227; Fam108a1; RGD1359682
Summary: Enables palmitoyl-(protein) hydrolase activity. Involved in several processes, including negative regulation of protein localization to microtubule; positive regulation of protein localization to endosome; and protein depalmitoylation. Located in plasma membrane; postsynaptic density; and recycling endosome membrane. Is active in glutamatergic synapse. Is anchored component of postsynaptic density membrane and anchored component of postsynaptic recycling endosome membrane. Orthologous to human ABHD17A (abhydrolase domain containing 17A, depalmitoylase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 94.8), Adrenal (RPKM 79.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q11

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (9775016..9781447)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (9124332..9132762)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (11992543..12000978)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH128456 (e-PCR)
- UniSTS:211764

D10Bwg1364e (e-PCR), detects polymorphism
- UniSTS:141497

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables palmitoyl-(protein) hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables palmitoyl-(protein) hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables palmitoyl-(protein) hydrolase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in negative regulation of NLRP3 inflammasome complex assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein localization to microtubule	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to endosome	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein depalmitoylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein localization to membrane	ISO Inferred from Sequence Orthology more info
involved_in regulation of postsynapse organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IEP Inferred from Expression Pattern more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in dendritic spine	IEA Inferred from Electronic Annotation more info
is_active_in endosome membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
located_in nuclear speck	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic density membrane	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in postsynaptic recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic recycling endosome membrane	IMP Inferred from Mutant Phenotype more info	PubMed
located_in recycling endosome membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: alpha/beta hydrolase domain-containing protein 17A

Names: abhydrolase domain-containing protein 17A; abhydrolase domain-containing protein FAM108A; family with sequence similarity 108, member A1; protein ABHD17A

NP_001006984.1

EC 3.1.2.22

XP_008763312.1

EC 3.1.2.22

XP_063119243.1

EC 3.1.2.22

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001006983.1 → NP_001006984.1 alpha/beta hydrolase domain-containing protein 17A

See identical proteins and their annotated locations for NP_001006984.1

Status: PROVISIONAL

Source sequence(s)

BC083686

UniProtKB/Swiss-Prot

Q5XIJ5

UniProtKB/TrEMBL

A6K8J3, A6K8J4

Related

ENSRNOP00000024576.3, ENSRNOT00000024576.4

Conserved Domains (1) summary

COG1073
Location:113 → 305

FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

9775016..9781447

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_008765090.4 → XP_008763312.1 alpha/beta hydrolase domain-containing protein 17A isoform X1

See identical proteins and their annotated locations for XP_008763312.1

UniProtKB/Swiss-Prot

Q5XIJ5

UniProtKB/TrEMBL

A6K8J3, A6K8J4

Conserved Domains (1) summary

COG1073
Location:113 → 305

FrsA; Fermentation-respiration switch protein FrsA, has esterase activity, DUF1100 family [Signal transduction mechanisms]
XM_063263173.1 → XP_063119243.1 alpha/beta hydrolase domain-containing protein 17A isoform X1

UniProtKB/Swiss-Prot

Q5XIJ5

UniProtKB/TrEMBL

A6K8J3, A6K8J4