Tgfbr3 transforming growth factor beta receptor 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Tgfbr3provided by RGD
Official Full Name: transforming growth factor beta receptor 3provided by RGD
Primary source: RGD:61821
See related: Ensembl:ENSRNOG00000002093 AllianceGenome:RGD:61821
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: betaglycan
Summary: Enables several functions, including activin binding activity; growth factor binding activity; and heparin binding activity. Involved in several processes, including animal organ regeneration; regulation of transforming growth factor beta receptor signaling pathway; and transforming growth factor beta receptor complex assembly. Located in cytoplasm; extracellular matrix; and extracellular space. Is integral component of plasma membrane. Part of receptor complex. Orthologous to human TGFBR3 (transforming growth factor beta receptor 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 475.0), Lung (RPKM 174.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 14p22

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	14	NC_086032.1 (2634294..2810269)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	14	NC_051349.1 (2489397..2665383)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	14	NC_005113.4 (3506416..3680508)

Chromosome 14 - NC_086032.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

identify the BGZP-C-binding site on TGF-beta2 and shed light on the specificity of BG for select TGF-beta-type GFs and the mechanisms by which BG influences their signaling
Title: TGF-β2 uses the concave surface of its extended finger region to bind betaglycan's ZP domain via three residues specific to TGF-β and inhibin-α.
Mating decreases plasma levels of TGFbeta1 and regulates myosalpinx expression of TGFbeta1/TGFBR3 in the rat.
Title: Mating decreases plasma levels of TGFβ1 and regulates myosalpinx expression of TGFβ1/TGFBR3 in the rat.
Data present the 2.0-A resolution crystal structure of the betaglycan ZP-C region in combination with a downstream region known as the external hydrophobic patch.
Title: Structure of betaglycan zona pellucida (ZP)-C domain provides insights into ZP-mediated protein polymerization and TGF-beta binding.
Betaglycan is an endogenous inhibin coreceptor required for high-sensitivity inhibin antagonism of activin signaling in rat anterior pituitary gonadotropes.
Title: Endogenous betaglycan is essential for high-potency inhibin antagonism in gonadotropes.
A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.
Title: A synthetic peptide from transforming growth factor-beta1 type III receptor prevents myocardial fibrosis in spontaneously hypertensive rats.
Prostaglandin E2 increases transforming growth factor-beta type III receptor expression through CCAAT enhancer-binding protein delta in osteoblasts
Title: Prostaglandin E2 increases transforming growth factor-beta type III receptor expression through CCAAT enhancer-binding protein delta in osteoblasts.
observed changes in TGF-beta activity and TbetaR isotype expression in rat lung that parallel the arrest in alveolarization seen with chronic hypoxia in early development
Title: Regulation of TGF-beta ligand and receptor expression in neonatal rat lungs exposed to chronic hypoxia.
FSH and estradiol increased betaglycan mRNA expression, most possibly through the protein kinase A pathway and the estrogen receptor-beta.
Title: Effect of follicle-stimulating hormone and estrogen on the expression of betaglycan messenger ribonucleic acid levels in cultured rat granulosa cells.
TGF-betaR-III seems to be associated with newly formed blood vessels during neovascularization in wound healing.
Title: Exogenous modulation of TGF-beta(1) influences TGF-betaR-III-associated vascularization during wound healing in irradiated tissue.
These results suggest a novel signaling mechanism for betaglycan, which is independent of the canonical TGF-beta signal pathway although it involves TGF-beta receptors and takes place through p38 pathways.
Title: Betaglycan induces TGF-beta signaling in a ligand-independent manner, through activation of the p38 pathway.

Submit: New GeneRIF Correction See all GeneRIFs (12)

General gene information

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Markers

D14Wox30 (e-PCR)
- UniSTS:518717

AU049133 (e-PCR)
- UniSTS:145581

d14rat69 (e-PCR)
- UniSTS:121007

AU049415 (e-PCR)
- UniSTS:145862

RH143675 (e-PCR)
- UniSTS:232921

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables BMP binding	ISO Inferred from Sequence Orthology more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables SMAD binding	ISO Inferred from Sequence Orthology more info
enables activin binding	IDA Inferred from Direct Assay more info	PubMed
enables coreceptor activity	ISO Inferred from Sequence Orthology more info
enables fibroblast growth factor binding	IDA Inferred from Direct Assay more info	PubMed
enables glycosaminoglycan binding	IBA Inferred from Biological aspect of Ancestor more info
enables glycosaminoglycan binding	ISO Inferred from Sequence Orthology more info
enables glycosaminoglycan binding	TAS Traceable Author Statement more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transforming growth factor beta binding	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to transforming growth factor beta binding	IPI Inferred from Physical Interaction more info	PubMed
contributes_to transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta binding	NAS Non-traceable Author Statement more info	PubMed
enables transforming growth factor beta receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transforming growth factor beta receptor activity	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor activity	TAS Traceable Author Statement more info	PubMed
enables transforming growth factor beta receptor activity, type III	IDA Inferred from Direct Assay more info	PubMed
enables transforming growth factor beta receptor activity, type III	ISO Inferred from Sequence Orthology more info
enables transforming growth factor beta receptor binding	IDA Inferred from Direct Assay more info	PubMed
enables transmembrane signaling receptor activity	ISO Inferred from Sequence Orthology more info
enables type II transforming growth factor beta receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables type II transforming growth factor beta receptor binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blastocyst development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within blood vessel remodeling	ISO Inferred from Sequence Orthology more info
involved_in cardiac epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell migration	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in collagen metabolic process	ISO Inferred from Sequence Orthology more info
involved_in definitive erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in definitive hemopoiesis	ISO Inferred from Sequence Orthology more info
involved_in epicardium-derived cardiac fibroblast cell development	ISO Inferred from Sequence Orthology more info
involved_in epithelial to mesenchymal transition	IBA Inferred from Biological aspect of Ancestor more info
involved_in epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula formation	ISO Inferred from Sequence Orthology more info
involved_in heart trabecula morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within in utero embryonic development	ISO Inferred from Sequence Orthology more info
involved_in intracellular signal transduction	ISO Inferred from Sequence Orthology more info
involved_in liver development	ISO Inferred from Sequence Orthology more info
involved_in muscular septum morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of apoptotic process involved in morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of canonical NF-kappaB signal transduction	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell migration	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial cell migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of epithelial cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of epithelial to mesenchymal transition	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of extracellular matrix assembly	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transforming growth factor beta receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within osteoblast differentiation	ISO Inferred from Sequence Orthology more info
involved_in outflow tract morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of BMP signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of SMAD protein signal transduction	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cardiac muscle cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration involved in sprouting angiogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within positive regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transforming growth factor beta receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in protein-containing complex assembly	IDA Inferred from Direct Assay more info	PubMed
NOT involved_in regulation of ERK1 and ERK2 cascade	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in regulation of transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to follicle-stimulating hormone	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to luteinizing hormone	ISO Inferred from Sequence Orthology more info
involved_in response to prostaglandin E	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within roof of mouth development	ISO Inferred from Sequence Orthology more info
involved_in secondary palate development	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	NAS Non-traceable Author Statement more info	PubMed
involved_in transforming growth factor beta receptor complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in transforming growth factor beta receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within vasculogenesis	ISO Inferred from Sequence Orthology more info
involved_in vasculogenesis involved in coronary vascular morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular cardiac muscle tissue morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular compact myocardium morphogenesis	ISO Inferred from Sequence Orthology more info
involved_in ventricular septum morphogenesis	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell surface	ISO Inferred from Sequence Orthology more info
located_in collagen-containing extracellular matrix	TAS Traceable Author Statement more info	PubMed
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
part_of inhibin-betaglycan-ActRII complex	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	TAS Traceable Author Statement more info	PubMed
part_of receptor complex	IDA Inferred from Direct Assay more info	PubMed
part_of receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: transforming growth factor beta receptor type 3

Names: TGF-beta receptor type 3; TGF-beta receptor type III; TGFR-3; transforming growth factor, beta receptor III

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_017256.1 → NP_058952.1 transforming growth factor beta receptor type 3 precursor

See identical proteins and their annotated locations for NP_058952.1

Status: PROVISIONAL

Source sequence(s)

M77809

UniProtKB/Swiss-Prot

P26342

UniProtKB/TrEMBL

A6KPK0

Related

ENSRNOP00000002867.3, ENSRNOT00000002867.5

Conserved Domains (2) summary

smart00241
Location:456 → 733

ZP; Zona pellucida (ZP) domain

pfam00100
Location:599 → 724

Zona_pellucida; Zona pellucida-like domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086032.1 Reference GRCr8

Range

2634294..2810269

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039091791.2 → XP_038947719.1 transforming growth factor beta receptor type 3 isoform X1

Conserved Domains (1) summary

smart00241
Location:378 → 655

ZP; Zona pellucida (ZP) domain
XM_039091792.2 → XP_038947720.1 transforming growth factor beta receptor type 3 isoform X2

Conserved Domains (1) summary

smart00241
Location:144 → 421

ZP; Zona pellucida (ZP) domain
XM_063273006.1 → XP_063129076.1 transforming growth factor beta receptor type 3 isoform X2