Pnpo pyridoxamine 5'-phosphate oxidase [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Pnpoprovided by RGD
Official Full Name: pyridoxamine 5'-phosphate oxidaseprovided by RGD
Primary source: RGD:621456
See related: Ensembl:ENSRNOG00000046493 AllianceGenome:RGD:621456
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables pyridoxamine-phosphate oxidase activity. Predicted to be involved in pyridoxal phosphate biosynthetic process. Human ortholog(s) of this gene implicated in pyridoxamine 5'-phosphate oxidase deficiency. Orthologous to human PNPO (pyridoxamine 5'-phosphate oxidase). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 157.2), Heart (RPKM 156.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q31

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (82421027..82427288, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (81924584..81930844, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (84874926..84881190, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PNPO may play a role in activity-dependent regulation of PLP level in the brain, which is involved in LTP induction and paired-pulse facilitation but not in enhancement of GABAergic inhibition.
Title: Pyridoxine 5'-phosphate oxidase, not pyridoxal kinase, involves in long-term potentiation induction in the rat dentate gyrus.
Pnpo is a candidate gene responsible for hypertension in Dahl-S rats
Title: Pyridoxine 5'-phosphate oxidase is a candidate gene responsible for hypertension in Dahl-S rats.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables FMN binding	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables pyridoxal phosphate binding	ISO Inferred from Sequence Orthology more info
enables pyridoxamine phosphate oxidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyridoxamine phosphate oxidase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyridoxamine phosphate oxidase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in pyridoxal phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within pyridoxal phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxal phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxal phosphate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxamine metabolic process	ISO Inferred from Sequence Orthology more info
involved_in pyridoxine biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytosol	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyridoxine-5'-phosphate oxidase

Names: pyridoxamine-phosphate oxidase; pyridoxine 5-phosphate oxidase

NP_072123.1

EC 1.4.3.5

XP_063125888.1

EC 1.4.3.5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.