Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Dnajc15provided by RGD
Official Full Name: DnaJ heat shock protein family (Hsp40) member C15provided by RGD
Primary source: RGD:1307154
See related: Ensembl:ENSRNOG00000009063 AllianceGenome:RGD:1307154
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Dnajd1
Summary: Predicted to enable ATPase activator activity. Predicted to be involved in protein import into mitochondrial matrix. Predicted to act upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Predicted to be located in mitochondrial inner membrane. Predicted to be part of PAM complex, Tim23 associated import motor. Orthologous to human DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Adrenal (RPKM 1136.9), Heart (RPKM 657.6) and 8 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 15q11

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	15	NC_086033.1 (59594314..59658862, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	15	NC_051350.1 (53182060..53249675, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	15	NC_005114.4 (59990131..60056710, complement)

Chromosome 15 - NC_086033.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to starvation	ISO Inferred from Sequence Orthology more info
acts_upstream_of mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of protein-containing complex assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of lipid metabolic process	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dnaJ homolog subfamily C member 15

Names: DnaJ (Hsp40) homolog, subfamily C, member 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001106050.1 → NP_001099520.1 dnaJ homolog subfamily C member 15

See identical proteins and their annotated locations for NP_001099520.1

Status: PROVISIONAL

Source sequence(s)

CH473951

UniProtKB/TrEMBL

A0A8I6GJ68, A6HTW7, D3ZCM4

Related

ENSRNOP00000012530.3, ENSRNOT00000012530.6

Conserved Domains (1) summary

cl02542
Location:39 → 142

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086033.1 Reference GRCr8

Range

59594314..59658862 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039093176.2 → XP_038949104.1 dnaJ homolog subfamily C member 15 isoform X3

Conserved Domains (1) summary

cl02542
Location:1 → 100

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...
XM_063274152.1 → XP_063130222.1 dnaJ homolog subfamily C member 15 isoform X1
XM_063274153.1 → XP_063130223.1 dnaJ homolog subfamily C member 15 isoform X1
XM_039093175.2 → XP_038949103.1 dnaJ homolog subfamily C member 15 isoform X2

UniProtKB/TrEMBL

A0A8I6GJ68

Related

ENSRNOP00000069451.1

Conserved Domains (1) summary

cl02542
Location:39 → 124

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...