Capg capping actin protein, gelsolin like [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Capgprovided by RGD
Official Full Name: capping actin protein, gelsolin likeprovided by RGD
Primary source: RGD:1311724
See related: Ensembl:ENSRNOG00000013668 AllianceGenome:RGD:1311724
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable actin filament binding activity; phosphatidylinositol-4,5-bisphosphate binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including actin filament severing; actin polymerization or depolymerization; and barbed-end actin filament capping. Predicted to act upstream of or within cellular response to interferon-gamma. Predicted to be located in several cellular components, including Flemming body; microtubule cytoskeleton; and nuclear lumen. Predicted to be active in actin cytoskeleton; cytoplasm; and extracellular space. Orthologous to human CAPG (capping actin protein, gelsolin like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Spleen (RPKM 175.4), Lung (RPKM 112.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 4q32

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	4	NC_086022.1 (106152912..106170010)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	4	NC_051339.1 (104594743..104611856)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	4	NC_005103.4 (100395693..100419447)

Chromosome 4 - NC_086022.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

UniSTS:498461 (e-PCR)
- UniSTS:498461

Capg (e-PCR), detects polymorphism
- UniSTS:498461

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables actin filament binding	IBA Inferred from Biological aspect of Ancestor more info
enables actin filament binding	IEA Inferred from Electronic Annotation more info
enables phosphatidylinositol-4,5-bisphosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables protein domain specific binding	ISO Inferred from Sequence Orthology more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in actin filament severing	IBA Inferred from Biological aspect of Ancestor more info
involved_in actin polymerization or depolymerization	IBA Inferred from Biological aspect of Ancestor more info
involved_in barbed-end actin filament capping	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell projection assembly	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell projection assembly	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to type II interferon	ISO Inferred from Sequence Orthology more info
involved_in central nervous system development	IBA Inferred from Biological aspect of Ancestor more info
NOT involved_in extracellular matrix disassembly	ISO Inferred from Sequence Orthology more info
NOT involved_in positive regulation of podosome assembly	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in Flemming body	IEA Inferred from Electronic Annotation more info
located_in Flemming body	ISO Inferred from Sequence Orthology more info
is_active_in actin cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IEA Inferred from Electronic Annotation more info
located_in centriole	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in melanosome	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in phagocytic vesicle	ISO Inferred from Sequence Orthology more info
located_in ruffle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: macrophage-capping protein

Names: actin regulatory protein CAP-G; capping protein (actin filament), gelsolin-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013086.1 → NP_001013104.1 macrophage-capping protein

See identical proteins and their annotated locations for NP_001013104.1

Status: PROVISIONAL

Source sequence(s)

BC079104

UniProtKB/Swiss-Prot

Q6AYC4

UniProtKB/TrEMBL

A0A8I6A6Z2, A6IAC6

Related

ENSRNOP00000087979.1, ENSRNOT00000108841.1

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086022.1 Reference GRCr8

Range

106152912..106170010

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006236661.5 → XP_006236723.1 macrophage-capping protein isoform X2

See identical proteins and their annotated locations for XP_006236723.1

UniProtKB/Swiss-Prot

Q6AYC4

UniProtKB/TrEMBL

A0A8I6A6Z2, A6IAC6

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
XM_006236663.5 → XP_006236725.1 macrophage-capping protein isoform X2

See identical proteins and their annotated locations for XP_006236725.1

UniProtKB/Swiss-Prot

Q6AYC4

UniProtKB/TrEMBL

A0A8I6A6Z2, A6IAC6

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
XM_039107321.2 → XP_038963249.1 macrophage-capping protein isoform X2

UniProtKB/Swiss-Prot

Q6AYC4

UniProtKB/TrEMBL

A0A8I6A6Z2, A6IAC6

Conserved Domains (3) summary

cd11289
Location:139 → 226

gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins

cd11290
Location:17 → 120

gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins

cd11292
Location:247 → 347

gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
XM_039107320.2 → XP_038963248.2 macrophage-capping protein isoform X1

UniProtKB/TrEMBL

A0A8L2Q9I9