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    Tspan1 tetraspanin 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 298436, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Tspan1provided by RGD
    Official Full Name
    tetraspanin 1provided by RGD
    Primary source
    RGD:1303308
    See related
    Ensembl:ENSRNOG00000023320 AllianceGenome:RGD:1303308
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in protein stabilization. Predicted to be located in several cellular components, including nucleoplasm; perinuclear region of cytoplasm; and vesicle. Predicted to be integral component of plasma membrane. Orthologous to human TSPAN1 (tetraspanin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Lung (RPKM 142.7), Kidney (RPKM 141.2) and 3 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    Location:
    5q35
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 5 NC_086023.1 (134883704..134896083, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 5 NC_051340.1 (129646139..129659383, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 5 NC_005104.4 (135019206..135032412, complement)

    Chromosome 5 - NC_086023.1Genomic Context describing neighboring genes Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose N-acetylglucosaminyltransferase 1 (beta 1,2-) Neighboring gene PIK3R3 upstream open reading frame Neighboring gene uncharacterized LOC120103122 Neighboring gene transfer RNA proline (anticodon AGG) 7 Neighboring gene phosphoinositide-3-kinase regulatory subunit 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Tetraspanin1 promotes NGF signaling by controlling TrkA receptor proteostasis. Ferrero Restelli F, et al. Cell Mol Life Sci, 2020 Jun. PMID 31440771
    2. Identification of a new proliferation-associated protein NET-1/C4.8 characteristic for a subset of high-grade cervical intraepithelial neoplasia and cervical carcinomas. Wollscheid V, et al. Int J Cancer, 2002 Jun 20. PMID 12115476
    3. The effect of NET-1 on the proliferation, migration and endocytosis of the SMMC-7721 HCC cell line. Wang GL, et al. Oncol Rep, 2012 Jun. PMID 22378020
    4. Tspan-1 interacts with the thiamine transporter-1 in human intestinal epithelial cells and modulates its stability. Nabokina SM, et al. Am J Physiol Gastrointest Liver Physiol, 2011 Nov. PMID 21836059, Free PMC Article
    5. Characterization of exosome-like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defense. Kesimer M, et al. FASEB J, 2009 Jun. PMID 19190083, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93753

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in protein stabilization ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cell junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in lysosomal membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tetraspanin-1
    Names
    tetraspan 1
    tspan-1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004236.1 → NP_001004236.1  tetraspanin-1

      See identical proteins and their annotated locations for NP_001004236.1

      Status: PROVISIONAL

      Source sequence(s)
      BC078938
      UniProtKB/Swiss-Prot
      Q6AYR9
      UniProtKB/TrEMBL
      A0A8L2R5U0, A6JZ68
      Related
      ENSRNOP00000018766.3, ENSRNOT00000018766.5
      Conserved Domains (1) summary
      pfam00335
      Location:7 → 236
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086023.1 Reference GRCr8

      Range
      134883704..134896083 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017593274.3 → XP_017448763.1  tetraspanin-1 isoform X1

      UniProtKB/Swiss-Prot
      Q6AYR9
      UniProtKB/TrEMBL
      A0A8L2R5U0, A6JZ68
      Conserved Domains (1) summary
      pfam00335
      Location:7 → 236
      Tetraspannin; Tetraspanin family

    2. XM_006238639.4 → XP_006238701.1  tetraspanin-1 isoform X1

      See identical proteins and their annotated locations for XP_006238701.1

      UniProtKB/Swiss-Prot
      Q6AYR9
      UniProtKB/TrEMBL
      A0A8L2R5U0, A6JZ68
      Conserved Domains (1) summary
      pfam00335
      Location:7 → 236
      Tetraspannin; Tetraspanin family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6AYR9.1 GenPept UniProtKB/Swiss-Prot:Q6AYR9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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