mt-Nd1 NADH dehydrogenase 1, mitochondrial [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: mt-Nd1provided by RGD
Official Full Name: NADH dehydrogenase 1, mitochondrialprovided by RGD
Primary source: RGD:620555
See related: AllianceGenome:RGD:620555
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus (strain: BN/SsNHsdMCW)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: ND1
Summary: Predicted to enable NADH dehydrogenase (ubiquinone) activity. Predicted to contribute to NADH dehydrogenase activity. Involved in response to hydroperoxide; response to organic cyclic compound; and response to xenobiotic stimulus. Located in dendrite; mitochondrion; and neuronal cell body. Biomarker of type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including MELAS syndrome; neurodegenerative disease (multiple); optic nerve disease (multiple); toxic shock syndrome; and type 2 diabetes mellitus. Orthologous to human MT-ND1 (mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Annotation release	Status	Assembly	Chr	Location
RS_2023_06	latest, but not current	mRatBN7.2 (GCF_015227675.2)	MT (non-nuclear)	NC_001665.2 (2740..3694)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	MT (non-nuclear)	NC_001665.2 (2740..3694)

Chromosome MT - NC_001665.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Electron transport complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.
Title: Complex I dysfunction underlies the glycolytic switch in pulmonary hypertensive smooth muscle cells.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC312657P1 (e-PCR)
- UniSTS:272907

PMC316374P5 (e-PCR)
- UniSTS:272966

RH136367 (e-PCR)
- UniSTS:210357

PMC31832P1 (e-PCR)
- UniSTS:273091

Homology

Orthologs from OrthoDB

Nd1; NADH1

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NADH dehydrogenase (ubiquinone) activity	ISO Inferred from Sequence Orthology more info
enables NADH dehydrogenase (ubiquinone) activity	ISS Inferred from Sequence or Structural Similarity more info
contributes_to NADH dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in aerobic respiration	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial electron transport, NADH to ubiquinone	ISS Inferred from Sequence or Structural Similarity more info
involved_in mitochondrial respiratory chain complex I assembly	ISO Inferred from Sequence Orthology more info
involved_in mitochondrial respiratory chain complex I assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to hydroperoxide	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrial inner membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in mitochondrial membrane	ISO Inferred from Sequence Orthology more info
part_of mitochondrial respiratory chain complex I	IBA Inferred from Biological aspect of Ancestor more info
part_of mitochondrial respiratory chain complex I	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Names: NADH dehydrogenase subunit 1

YP_665629.1

TAA stop codon is completed by the addition of 3' A residues to the mRNA

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_001665.2 Reference assembly

Range

2740..3694

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

YP_665629.1 NADH dehydrogenase subunit 1 (mitochondrion) [Rattus norvegicus]

See identical proteins and their annotated locations for YP_665629.1

Status: PROVISIONAL

UniProtKB/Swiss-Prot

O63197, P03889, Q37653

UniProtKB/TrEMBL

D2E6L7, H9KVF8, Q8HID1, Q8SEZ8

Related

ENSRNOP00000049172.4

Conserved Domains (1) summary

MTH00104
Location:1 → 318

ND1; NADH dehydrogenase subunit 1; Provisional