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    Sin3a SIN3 transcription regulator family member A [ Rattus norvegicus (Norway rat) ]

    Gene ID: 363067, updated on 6-Jun-2024

    Summary

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    Official Symbol
    Sin3aprovided by RGD
    Official Full Name
    SIN3 transcription regulator family member Aprovided by RGD
    Primary source
    RGD:1311598
    See related
    Ensembl:ENSRNOG00000032254 AllianceGenome:RGD:1311598
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Enables RNA binding activity. Involved in several processes, including aging; cellular response to dopamine; and regulation of transcription from RNA polymerase II promoter in response to oxidative stress. Located in chromatin. Part of protein-containing complex. Used to study transient cerebral ischemia. Human ortholog(s) of this gene implicated in chromosome 15q24 deletion syndrome. Orthologous to human SIN3A (SIN3 transcription regulator family member A). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in Thymus (RPKM 103.8), Adrenal (RPKM 99.4) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Sin3a in Genome Data Viewer
    Location:
    8q24
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (66377471..66432150)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (57481539..57536195)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (61748590..61803314)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene snurportin 1 Neighboring gene uncharacterized LOC103693102 Neighboring gene protein tyrosine phosphatase, non-receptor type 9 Neighboring gene uncharacterized LOC102553607 Neighboring gene uncharacterized LOC120094171 Neighboring gene uncharacterized LOC120094172 Neighboring gene mannosidase, alpha, class 2C, member 1 Neighboring gene nei-like DNA glycosylase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Increased binding of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST. Dharap A, et al. ASN Neuro, 2013 Oct 23. PMID 24063527, Free PMC Article
    2. Development of type 2 diabetes following intrauterine growth retardation in rats is associated with progressive epigenetic silencing of Pdx1. Park JH, et al. J Clin Invest, 2008 Jun. PMID 18464933, Free PMC Article
    3. A role for transcriptional repressor methyl-CpG-binding protein 2 and plasticity-related gene serum- and glucocorticoid-inducible kinase 1 in the induction of inflammatory pain states. Géranton SM, et al. J Neurosci, 2007 Jun 6. PMID 17553988, Free PMC Article
    4. In vivo GSH depletion induces c-myc expression by modulation of chromatin protein complexes. Torres L, et al. Free Radic Biol Med, 2009 Jun 1. PMID 19289167
    5. Epigenetic mechanisms in the dopamine D2 receptor-dependent inhibition of the prolactin gene. Liu JC, et al. Mol Endocrinol, 2005 Jul. PMID 15731170

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. MeCP2 is an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex
      Title: MeCP2 behaves as an elongated monomer that does not stably associate with the Sin3a chromatin remodeling complex.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein-containing complex binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription corepressor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables transcription corepressor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in activation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to dopamine IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within cellular response to glucose stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to tert-butyl hydroperoxide IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in cerebral cortex neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within hematopoietic progenitor cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heterochromatin formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within in utero embryonic development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of circadian rhythm ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of protein localization to nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of G2/M transition of mitotic cell cycle ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of defense response to virus by host ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within protein localization ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of axon extension ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of hormone levels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to methylglyoxal ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in type I interferon-mediated signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of Sin3-type complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Sin3-type complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of chromatin IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of histone deacetylase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription repressor complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    paired amphipathic helix protein Sin3a
    Names
    SIN3 homolog A, transcription regulator
    SIN3 transcription regulator homolog A
    transcriptional regulator, SIN3A

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001395640.1 → NP_001382569.1  paired amphipathic helix protein Sin3a

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000008
      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      66377471..66432150
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_008766301.4 → XP_008764523.1  paired amphipathic helix protein Sin3a isoform X1

      See identical proteins and their annotated locations for XP_008764523.1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    2. XM_063265753.1 → XP_063121823.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2

    3. XM_039081736.2 → XP_038937664.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2
      Related
      ENSRNOP00000055480.3
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    4. XM_008766299.4 → XP_008764521.1  paired amphipathic helix protein Sin3a isoform X1

      See identical proteins and their annotated locations for XP_008764521.1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    5. XM_039081735.2 → XP_038937663.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    6. XM_008766302.4 → XP_008764524.1  paired amphipathic helix protein Sin3a isoform X1

      See identical proteins and their annotated locations for XP_008764524.1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    7. XM_063265751.1 → XP_063121821.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2

    8. XM_039081737.2 → XP_038937665.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    9. XM_039081734.2 → XP_038937662.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    10. XM_006243129.5 → XP_006243191.1  paired amphipathic helix protein Sin3a isoform X1

      See identical proteins and their annotated locations for XP_006243191.1

      UniProtKB/TrEMBL
      D3ZBP2
      Conserved Domains (1) summary
      COG5602
      Location:8 → 1214
      Sin3; Histone deacetylase complex, regulatory component SIN3 [Chromatin structure and dynamics]

    11. XM_063265752.1 → XP_063121822.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2

    12. XM_063265750.1 → XP_063121820.1  paired amphipathic helix protein Sin3a isoform X1

      UniProtKB/TrEMBL
      D3ZBP2

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001108761.1: Suppressed sequence

      Description
      NM_001108761.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
    Nucleotide Protein Strain
    Heading Accession and Version

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