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    Nuf2 NUF2, NDC80 kinetochore complex component [ Mus musculus (house mouse) ]

    Gene ID: 66977, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Nuf2provided by MGI
    Official Full Name
    NUF2, NDC80 kinetochore complex componentprovided by MGI
    Primary source
    MGI:MGI:1914227
    See related
    Ensembl:ENSMUSG00000026683 AllianceGenome:MGI:1914227
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cdca1; NUF2R; 2410003C07Rik
    Summary
    Predicted to be involved in kinetochore organization; mitotic spindle organization; and nuclear division. Predicted to act upstream of or within attachment of spindle microtubules to kinetochore. Predicted to be located in cytosol; kinetochore; and nucleoplasm. Predicted to be part of Ndc80 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in castration-resistant prostate carcinoma and pancreatic cancer. Orthologous to human NUF2 (NUF2 component of NDC80 kinetochore complex). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in CNS E11.5 (RPKM 19.6), liver E14 (RPKM 14.3) and 10 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Nuf2 in Genome Data Viewer
    Location:
    1 H2.3; 1 76.84 cM
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (169325503..169359033, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (169497934..169531464, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 34535 Neighboring gene predicted gene, 53643 Neighboring gene STARR-positive B cell enhancer ABC_E9189 Neighboring gene predicted gene, 34624 Neighboring gene STARR-seq mESC enhancer starr_02975 Neighboring gene predicted gene, 18900

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation. Zhang T, et al. Cell Cycle, 2015. PMID 26054848, Free PMC Article
    2. Prc1-rich kinetochores are required for error-free acentrosomal spindle bipolarization during meiosis I in mouse oocytes. Yoshida S, et al. Nat Commun, 2020 May 27. PMID 32461611, Free PMC Article
    3. Implications for kinetochore-microtubule attachment from the structure of an engineered Ndc80 complex. Ciferri C, et al. Cell, 2008 May 2. PMID 18455984, Free PMC Article
    4. The Ndc80p complex from Saccharomyces cerevisiae contains conserved centromere components and has a function in chromosome segregation. Wigge PA, et al. J Cell Biol, 2001 Jan 22. PMID 11266451, Free PMC Article
    5. The KMN protein network--chief conductors of the kinetochore orchestra. Varma D, et al. J Cell Sci, 2012 Dec 15. PMID 23418356, Free PMC Article

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Nuf2 is a critical regulator of meiotic cell cycle progression in mammalian oocytes.
      Title: Nuf2 is required for chromosome segregation during mouse oocyte meiotic maturation.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in attachment of mitotic spindle microtubules to kinetochore IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in attachment of spindle microtubules to kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in chromosome segregation NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in kinetochore organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in meiotic chromosome segregation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mitotic spindle assembly checkpoint signaling NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in mitotic spindle organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of Ndc80 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Ndc80 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in kinetochore NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    kinetochore protein Nuf2
    Names
    cell division cycle-associated protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355159.1 → NP_001342088.1  kinetochore protein Nuf2

      Status: VALIDATED

      Source sequence(s)
      AK132467, AK162249
      Consensus CDS
      CCDS15463.1
      UniProtKB/Swiss-Prot
      Q8BTK7, Q8VE05, Q99P69, Q9CST5
      Related
      ENSMUSP00000028000.8, ENSMUST00000028000.13
      Conserved Domains (2) summary
      pfam03800
      Location:3 → 145
      Nuf2; Nuf2 family
      cl25732
      Location:166 → 456
      SMC_N; RecF/RecN/SMC N terminal domain

    2. NM_023284.3 → NP_075773.2  kinetochore protein Nuf2

      See identical proteins and their annotated locations for NP_075773.2

      Status: VALIDATED

      Source sequence(s)
      AK132467
      Consensus CDS
      CCDS15463.1
      UniProtKB/Swiss-Prot
      Q8BTK7, Q8VE05, Q99P69, Q9CST5
      Related
      ENSMUSP00000106999.2, ENSMUST00000111368.8
      Conserved Domains (2) summary
      pfam03800
      Location:3 → 145
      Nuf2; Nuf2 family
      cl25732
      Location:166 → 456
      SMC_N; RecF/RecN/SMC N terminal domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      169325503..169359033 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q99P69.2 GenPept UniProtKB/Swiss-Prot:Q99P69

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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